High and low BMI increase the risk of miscarriage after IVF/ICSI and FET

Veleva, Zdravka; Tiitinen, Aila; Vilska, Sirpa; Hydén-Granskog, Christel; Tomás, Cǎndido; Martikainen, Hannu; Tapanainen, Juha S.

doi:10.1093/humrep/den017

Cited by 164 publications

(134 citation statements)

References 72 publications

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“…In a Finnish Table 2. Comparison of mean body composition in primigravidas and multigravidas who miscarried with those who did not study, the miscarriage rate was found to be higher at the extremes of weight compared with normal-weight women [12] . In a study examining the probability of pregnancy after assisted reproduction the odds ratio was 0.73 for class 1 obese women and 0.5 for class 2-3 obese women, compared with women in the normal BMI category [13] .…”

Section: Discussionmentioning

confidence: 85%

Miscarriage after Sonographic Confirmation of an Ongoing Pregnancy in Women with Moderate and Severe Obesity

O’Dwyer¹,

Monaghan²,

Fattah³

et al. 2012

Obes Facts

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Objective:To compare the incidence of spontaneous miscarriage in women with moderate to severe obesity to that in women with a normal BMI after sonographic confirmation of the foetal heart rate in the first trimester. Methods: Women were enrolled in a prospective observational study at their convenience in the first trimester after an ultrasound confirmed an ongoing singleton pregnancy with foetal heart activity present. Maternal height and weight were measured digitally and BMI was calculated. Results: In the 3,000 women enrolled, the miscarriage rate overall was 3.9% (n = 117). The mean gestational age at enrolment was 11.1 weeks. In the class 2-3 (BMI 1 34.9 kg/m 2 ) obese primigravidas the miscarriage rate was 11.3% (n = 8) compared with 2.7% (n = 24) in the normal BMI category (p = 0.003), and 3.7% (n = 5) in the class 1 obese category (not significant). In multigravidas, there was no increased rate of miscarriage among class 2-3 obese women compared with multigravidas in the normal BMI category. The mean body composition values showed that primigravidas who miscarried had both increased fat and fat-free masses compared with those who did not, but multigravidas who miscarried had a similar fat mass and fat-free mass with those who did not. Conclusions: In women with sonographic evidence of foetal heart activity in the first trimester, the rate of spontaneous miscarriage is low. It was increased in moderate to severely obese primigravidas, but was not increased in other obese women compared to women in the normal BMI category.

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Section: Discussionmentioning

confidence: 85%

Miscarriage after Sonographic Confirmation of an Ongoing Pregnancy in Women with Moderate and Severe Obesity

O’Dwyer¹,

Monaghan²,

Fattah³

et al. 2012

Obes Facts

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“…One was the study of Veleva et al (2008) , which showed that the BMI graph curve that represents how BMI affects the miscarriage rate is U-shaped, meaning that patients of low weight also has their increased risk, independent of patient age ( Figure 3 ). Moreover, the revision of Rittenberg et al, 2011 revealed increased miscarriage rate in 14 studies (RR 1.36, 95 % CI 1.13 to 1.64, p et al, 2010, despite the rate being increased, this increase was not significant, as in Vilarino et al, 2011, Zhang et al, 2010and Sathya et al .,2010.…”

Section: Miscarriage Ratementioning

confidence: 99%

Obese women and in vitro fertilization: results

Koatz¹,

Souza²

2013

JBRA Assisted Reproduction

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Objective: To evaluate the effect of female obesity on the results of In Vitro Fertilization (IVF) in six parameters: dose of gonadotropins required, number of oocytes retrieved and fertilization, pregnancy, miscarriage and live births rates. method: Literature search in PUBMED articles in English between 2008 and 2013 using the following keywords: female, obesity and In Vitro Fertilization. 15 articles were selected for this work. Results: From the total only two articles showed that female obesity does not alter the results of IVF. The remaining 13 came to the conclusion that obesity has a negative effect on some of the parameters evaluated. However, there was no consensus about its effect. Conclusion: Further studies are needed to clarify the real role of obesity in female patients undergoing IVF, but the weight loss prior to treatment should always be encouraged. keywords: Female, Obesity and In Vitro Fertilization. RESUmOObjetivo: Avaliar o efeito da obesidade feminina nos resultados da fertilização in vitro (FIV) em seis parâmetros: recuperados e fertilização, gravidez, aborto e taxas de nascidos vivos. método: Inglês, entre 2008 e 2013, utilizando as seguintes palavraschave: mulher, obesidade e fertilização in vitro. 15 artigos foram selecionados para este trabalho. Resultados: Do total apenas dois artigos mostraram que a obesidade feminina não altera os resultados de fertilização in vitro. Os restantes 13 chegaram à conclusão de que a obesidade tem um efeito negativo sobre alguns dos parâmetros avaliados. no entanto, não houve consenso sobre o seu efeito. Conclusão: Mais estudos são necessários para esclarecer o real papel da obesidade em pacientes do sexo feminino submetidas a fertilização in vitro, mas a perda de peso antes do tratamento deve ser sempre incentivada. Palavras-chave: feminino, obesidade e fertilização in vitro.

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“…However, not all studies corroborate these findings (6,11). The impact of obesity on miscarriage rates in ART is more controversial (5,9,(12)(13)(14)(15).…”

mentioning

confidence: 99%

Surrogate obesity negatively impacts pregnancy rates in third-party reproduction

DeUgarte

Deugarte

Sahakian

2010

Fertility and Sterility

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High and low BMI increase the risk of miscarriage after IVF/ICSI and FET

Abstract: Obese and underweight women have an increased risk of miscarriage, and hormonally substituted FET is associated with an even higher MR.

Cited by 164 publications

References 72 publications

Miscarriage after Sonographic Confirmation of an Ongoing Pregnancy in Women with Moderate and Severe Obesity

Miscarriage after Sonographic Confirmation of an Ongoing Pregnancy in Women with Moderate and Severe Obesity

Obese women and in vitro fertilization: results

Surrogate obesity negatively impacts pregnancy rates in third-party reproduction

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