High Anticomplementary Activity in Au-Antigen-Positive Cirrhosis

Thiry, Lise; Clinet, G.; Cremer, Michel; Yourassowsky, E; Toussaint, C; Sternon, J; Dachy, A; Govaerts, André

doi:10.1016/s0140-6736(71)90469-7

Cited by 3 publications

(3 citation statements)

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“…High titres of anticomplementary activity are often associated with higher titres of Au Supported by a grant from the 'Centre d'Etudes Princesse JosCphine Charlotte' antigen and in these sera it is very probable that part of the Au antigen is bound to antibody and that an excess of antigen can be detected at the highest dilutions. We previously showed [9] that such sera were more frequent in cases of cirrhosis than in those of acute hepatitis or of healthy carriers. In other anticomplementary sera, the Au antigen is not detected, either because it is not in excess of antibody, or because another antigen is bound to the antibody.…”

Section: Introductionmentioning

confidence: 95%

The Use of Complement Fixation Tests to Detect Australia Antigen‐Antibody Complexes and Antibodies to a Tween Antigen¹

et al. 1973

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Abstract. Indications were obtained that Australia antigen‐antibody complexes are more frequent in patients with cirrhosis than in other Australia antigen‐positive individuals. The evidences were: (1) Among sera with high titres of Australia antigen, anticomplementary activity was detected at lower dilutions in 53% of the cases of cirrhosis, as compared to 14 and 7% in hepatitis patients and carriers, respectively. (2) Among anticomplementary sera which did not show Australia antigen at higher dilutions, the antigen was unmasked after heating at 85 °C in 4 of 7 cases of cirrhosis and in 2 of 11 other patients. On the other hand, a new type of antibody was demonstrated in three patients who had experienced a progressive decrease of Australia antigen titre; the antibodies were detected after the disappearance of the antigen, but they reacted only with some antigenic component of Australia‐positive sera which was unmasked after treatment with Tween 80.

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Section: Introductionmentioning

confidence: 95%

The Use of Complement Fixation Tests to Detect Australia Antigen‐Antibody Complexes and Antibodies to a Tween Antigen¹

et al. 1973

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“…For the evaluation of anticomplementary activity we used the complement fixation method described by T hiry el al. [6] in their study of patients with cirrhosis. Steinberg's [5] method was used to determine the presence of antiglobulin anti bodies.…”

Section: Methodsmentioning

confidence: 99%

Antiglobulin Antibodies and Anticomplementary Factors in Hepatitis B Antigenaemia

Vos¹,

Vos²

1974

Acta Haematol

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A study of an apparently healthy population of Southern African Negroes showed that the HB antigen carrier state may predispose these subjects to produce a higher incidence of antiglobulin antibodies and anticomplementary factors. It is presumed that the anticomplementary factors represent excess HB antigen-antibody complexes in a modified form while the antiglobulin antibodies are the host’s humoral response to the modified complexes.

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“…High titres of anticomplementary activity are often associated with higher titres of Au antigen and in these sera it is very probable that part of the Au antigen is bound to antibody and that an excess of antigen can be detected at the highest dilutions. We previously showed [9] that such sera were more frequent in cases of cirrhosis than in those of acute hepatitis or of healthy carriers. In other anticomplementary sera, the Au antigen is not detected, either because it is not in excess of antibody, or because another antigen is bound to the antibody.…”

Section: Introductionmentioning

confidence: 95%

The Use of Complement Fixation Tests to Detect Australia Antigen-Antibody Complexes and Antibodies to a Tween Antigen

Thiry¹,

Client²,

Toussaint³

et al. 1973

Vox Sanguinis

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Indications were obtained that Australia antigen-antibody complexes are more frequent in patients with cirrhosis than in other Australia antigen-positive individuals. The evidences were: (1) Among sera with high titres of Australia antigen, anticomplementary activity was detected at lower dilutions in 53% of the cases of cirrhosis, as compared to 14 and 7% in hepatitis patients and carriers, respectively. (2) Among anticomplementary sera which did not show Australia antigen at higher dilutions, the antigen was unmasked after heating at 85 °C in 4 of 7 cases of cirrhosis and in 2 of 11 other patients. On the other hand, a new type of antibody was demonstrated in three patients who had experienced a progressive decrease of Australia antigen titre; the antibodies were detected after the disappearance of the antigen, but they reacted only with some antigenic component of Australia-positive sera which was unmasked after treatment with Tween 80.

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High Anticomplementary Activity in Au-Antigen-Positive Cirrhosis

Cited by 3 publications

References 4 publications

The Use of Complement Fixation Tests to Detect Australia Antigen‐Antibody Complexes and Antibodies to a Tween Antigen¹

The Use of Complement Fixation Tests to Detect Australia Antigen‐Antibody Complexes and Antibodies to a Tween Antigen¹

Antiglobulin Antibodies and Anticomplementary Factors in Hepatitis B Antigenaemia

The Use of Complement Fixation Tests to Detect Australia Antigen-Antibody Complexes and Antibodies to a Tween Antigen

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High Anticomplementary Activity in Au-Antigen-Positive Cirrhosis

Cited by 3 publications

References 4 publications

The Use of Complement Fixation Tests to Detect Australia Antigen‐Antibody Complexes and Antibodies to a Tween Antigen1

The Use of Complement Fixation Tests to Detect Australia Antigen‐Antibody Complexes and Antibodies to a Tween Antigen1

Antiglobulin Antibodies and Anticomplementary Factors in Hepatitis B Antigenaemia

The Use of Complement Fixation Tests to Detect Australia Antigen-Antibody Complexes and Antibodies to a Tween Antigen

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The Use of Complement Fixation Tests to Detect Australia Antigen‐Antibody Complexes and Antibodies to a Tween Antigen¹

The Use of Complement Fixation Tests to Detect Australia Antigen‐Antibody Complexes and Antibodies to a Tween Antigen¹