High antioxidant activity of gadolinium–yttrium orthovanadate nanoparticles in cell-free and biological milieu

Abstract

Oxidative stress caused by an overproduction of reactive oxygen species (ROS) is the key factor in developing a variety of pathological conditions. Recently various nanomaterials have attracted growing interest as nanoantioxidants with ROS-regulating ability. Here, for the first time, we report on high antioxidant behavior (enzyme-like activity) of GdYVO4:Eu3+ nanoparticles (GdYVO NPs) revealed by spectroscopic methods both in cell-free and biological milieu using various ROS sensors. It was revealed that GdYVO NPs (d = 2 nm) effectively scavenge hydroxyl radicals · O H , superoxide anions O 2 · − , hydrogen peroxide H 2 O 2 , peroxyl radicals R O O · , and remarkably reduce the lipopolysaccharide-induced ROS generation in rat leukocytes. The antioxidant activity of GdYVO NPs is ascribed to high amount of V4+ and V3+ ions in the structure of the NPs and the reversible switching V 3 + ↔ V 4 + and V 4 + ↔ V 5 + vanadium oxidation states.

·OH-Free Catalytic Decomposition of H2O2 by GdVO4:Eu3+ Nanoparticles

“…The same effect was observed in our previous work for GdYVO 4 :Eu 3+ NPs in rat leukocytes under the conditions of lipopolysaccharide-induced ROS generation. 20…”

UV-Light-Activated (Gd,Y)VO4:Eu3+ Nanoparticles for Radiotherapy Enhancement

“…This effect is explained by the radical-scavenging ability (antioxidant action) of the NPs associated with a high amount of V 4+ and V 3+ ions in their crystal lattice (besides V 5+ ions) and the possibility of vanadium ions to switch between different oxidation states V 3+ ↔ V 4+ and V 4+ ↔ V 5+ . , Oxygen vacancies (V O ) are known to be the main structural defects of metal oxide NPs. Consequently, the formation of V O causes the redistribution of the excess electrons among the nearest neighboring vanadium ions forming V 4+ and V 3+ centers.…”

The state of metabolic parameters of the blood in white rats under conditions of long-term oral administration of gadolinium orthovanadate nanoparticles under food stress

“…В експериментах in vitro NP GdVO 4 :Eu 3+ проявили ензимоподібні властивості: у водних розчинах спостерігали пригнічення утворення супероксид-аніона (подібно до дії супероксиддисмутази) та прискорення розкладання пероксиду водню (подібно до дії каталази) (Maksimchuk et al, 2021). Антиоксидантні властивості NP GdVO 4 :Eu 3+ спостерігали також під час рентгенівського опромінення водних розчинів, незважаючи на те, що наночастинки поглинають м'який рентген, який застосовувався в експерименті.…”