High Antioxidant and Phenolic Contents Related to Antibacterial Activity against Gastrointestinal Pathogenic Bacteria of Some Thai Medicinal Plants

Phalanisong, Parichat; Vichitphan, Kanit; Han, Jaehong; Vichitphan, Sukanda

doi:10.5530/pj.2018.2.58

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…Phenolic compounds and flavonoids have been reported to be the main bioactives present in most medicinal plants. 34 The content of these compounds could be varied due to varieties and growth conditions. Curcumin is a yellow-orange pigment which naturally occurs in the spice plant.…”

Section: Discussionmentioning

confidence: 99%

The Diversity of Biologically Active Compounds in the Rhizomes of Recently Discovered Zingiberaceae Plants Native to North Eastern Thailand

Chumroenphat¹,

Somboonwatthanakul²,

Saensouk³

et al. 2019

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Objective: To identify and quantify the bioactive compounds, along with biological activities, of native Thai edible Zingiberaceae. Methods: The bioactive compounds evaluated were phenolic acids, flavonoid, vitamin C, curcumin, 6-gingerol, eugenol and essential amino acids; analyses involved HPLC and LCMS/MS. Antioxidant activities were assessed by DPPH and FRAP assays. Results: Zingiber officinale was the richest source of bioactive compounds, followed by Z. officinale, Alpinia zerumbet and Alpinia conchigera. Total phenolic content and total flavonoid contents ranged widely across these species (17 to 200 mg GAE/100 g DW and 17 to 66 mg RE/100 g DW). All the species studied possessed strong antiglycation properties, ranging from 82 to 98%, with strong positive correlations of total phenolic content and antioxidant activity. The contents of curcumin, 6-gingerol, eugenol and vitamin C were in the range of 1 to 26, 1 to 140 µg/ g DW, 5 to 1600 and 4 to 21 mg/100 g DW, respectively. Seven essential amino acids identified by using LCMS/MS were found in most samples studied ranging from 2 to 6752 µg/100 g DW. Conclusion: Z. officinale is an abundant source of bioactive compounds and antioxidant activity in all these samples. These plants are fresh sources for developing novel functional ingredients in either food or cosmetics.

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Section: Discussionmentioning

confidence: 99%

The Diversity of Biologically Active Compounds in the Rhizomes of Recently Discovered Zingiberaceae Plants Native to North Eastern Thailand

Chumroenphat¹,

Somboonwatthanakul²,

Saensouk³

et al. 2019

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“…To analyze the structural changes in bacterial cells, SEM and TEM were observed using Hitachi SU8010 and Hitachi H-7650 (Hitachi, Tokyo, Japan), respectively [48,49]. Photoinactivation experiments were carried out using different light sources (5 W, 15 W, 23 W, 32 W, and 45 W) as well as in darkness, with exposure times of 15, 30, and 60 min.…”

Section: Morphology Analysismentioning

confidence: 99%

“…To analyze the structural changes in bacterial cells, SEM and TEM were observed using Hitachi SU8010 and Hitachi H-7650 (Hitachi, Tokyo, Japan), respectively [48,49]. Briefly, A. hydrophila cells were exposed to CFL light for 30 min in the presence of emodin and the untreated cells were chosen for the morphological assessment.…”

Section: Morphology Analysismentioning

confidence: 99%

Natural Sunlight-Mediated Emodin Photoinactivation of Aeromonas hydrophila

Urgesa,

Lu,

Gao

et al. 2024

IJMS

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Aeromonas hydrophila can be a substantial concern, as it causes various diseases in aquaculture. An effective and green method for inhibiting A. hydrophila is urgently required. Emodin, a naturally occurring anthraquinone compound, was exploited as a photo-antimicrobial agent against A. hydrophila. At the minimum inhibitory concentration of emodin (256 mg/L) to inactivate A. hydrophilia in 30 min, an 11.32% survival rate was observed under 45 W white compact fluorescent light irradiation. In addition, the antibacterial activity under natural sunlight (0.78%) indicated its potential for practical application. Morphological observations demonstrated that the cell walls and membranes of A. hydrophila were susceptible to damage by emodin when exposed to light irradiation. More importantly, the photoinactivation of A. hydrophila was predominantly attributed to the hydroxyl radicals and superoxide radicals produced by emodin, according to the trapping experiment and electron spin resonance spectroscopy. Finally, a light-dependent reactive oxygen species punching mechanism of emodin to photoinactivate A. hydrophila was proposed. This study highlights the potential use of emodin in sunlight-mediated applications for bacterial control, thereby providing new possibilities for the use of Chinese herbal medicine in aquatic diseases prevention.

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“…The average IC50 value of positive control quercetin was 6.07 μg/mL. The previous work reported the IC50 of water extract of C. sappan of 15.08 -53.61 μg/mL [50], the hydroethanolic extract of 32.37 μg/mL [37], and ethanolic extract of 2 -140 μg/mL [38,44,51]. In the case of H. sabdariffa, the IC50 values of water extract and hydroethanolic extract were 516 μg/mL [41] and 280 μg/mL [41].…”

Section: Synergistic Antioxidant Activity Of Plants' Combinationmentioning

confidence: 99%

Synergistic Antioxidant Activity and Optimal Microwave-Assisted Extraction Condition of Caesalpinia sappan L., Hibiscus sabdariffa L., and Clitoria ternatea L. Combinations

et al. 2022

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The aims of this work were to evaluate the synergistic antioxidant activity and optimize microwave-assisted extraction of Caesalpinia sappan L., Hibiscus sabdariffa L., and Clitoria ternatea L. combinations. The simplex lattice design was applied to evaluate the synergistic antioxidant activity. The mass ratios of the 3 plants that exhibited synergistic antioxidant activity were further used to investigate the optimal condition of microwave-assisted extraction by Box-Behnken design. Results showed that the synergistic antioxidant activity among the 3 plants: Which was determined by the combination index, was observed at various mass ratios, especially at the equal mass ratio. The optimal microwave-assisted extraction condition providing the best antioxidant activity of the plant extract was microwave power of 300 W for 30 s and 3 cycles. This condition gave the extraction yield of 31.03 ± 0.26 %, total phenolic content of 72.03 ± 3.83 mg GAE/g extract, total flavonoid content of 15.18 ± 0.42 mg CE/g extract, half-maximal inhibitory concentration (IC50) from DPPH assay of 178.16 ± 15.54 µg/mL and IC50 from FRAP assay of 75.26 ± 4.44 µg/mL. The optimal extract showed no toxicity on HepG2 cells although the tested concentration was up to 1 mg/mL with an IC50 value of 5.45 mg/mL. So, a mixture of the 3 colored plants could be used as a supplementary antioxidant product with a safety profile. HIGHLIGHTS Synergistic antioxidant activity was observed among three colored plants The optimal MAE condition was microwave power of 300 W for 30 s and three cycles The optimal extract did not toxic although the tested concentration was up to 1 mg/mL The IC50 of extract on cell viability was 5.45 mg/mL GRAPHICAL ABSTRACT

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High Antioxidant and Phenolic Contents Related to Antibacterial Activity against Gastrointestinal Pathogenic Bacteria of Some Thai Medicinal Plants

Cited by 7 publications

References 21 publications

The Diversity of Biologically Active Compounds in the Rhizomes of Recently Discovered Zingiberaceae Plants Native to North Eastern Thailand

The Diversity of Biologically Active Compounds in the Rhizomes of Recently Discovered Zingiberaceae Plants Native to North Eastern Thailand

Natural Sunlight-Mediated Emodin Photoinactivation of Aeromonas hydrophila

Synergistic Antioxidant Activity and Optimal Microwave-Assisted Extraction Condition of Caesalpinia sappan L., Hibiscus sabdariffa L., and Clitoria ternatea L. Combinations

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