High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Zhou, Yanrong; Jiang, Xiaohan; Tong, Ting; Fang, Liurong; Wu, Yuan; Liang, Jiangong; Xiao, Shaobo

doi:10.1039/d0ra01387k

Cited by 29 publications

(22 citation statements)

References 72 publications

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“…PEDV infections in Vero cells have also been inhibited with silver sulfide nanoclusters by three orders of magnitude when compared to untreated controls [ 377 ]. Tellurium nanoparticles coated with bovine serum albumin were shown to form triangular nanostar-like structures capable of inhibiting PEDVs [ 378 ]. The nanostars were further functionalized with a heparan sulfate receptor and shown to also inhibit PRRSV in MARC-145 cells by blocking virus internalization and reducing ROS production.…”

Section: Discussionmentioning

confidence: 99%

Nanotechnology for virus treatment

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Nanotechnology for virus treatment

et al. 2021

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Section: Covid‐19 Therapeutics: Antiviral Treatments and Vaccinesmentioning

confidence: 99%

“…[ 155 ] The exact mechanism depends greatly on the virus. Concerning the applicability against SARS‐CoV‐2, there are promising results of nanoparticles against related coronaviruses like the porcine epidemic diarrhea virus (PEDV) [ 157,158 ] ( Figure ). On the other hand, zinc, silver, and copper cations also showed antiviral activity against different coronaviruses with characteristics similar to SARS‐CoV‐2.…”

Section: Covid‐19 Therapeutics: Antiviral Treatments and Vaccinesmentioning

confidence: 99%

Nanotechnology Responses to COVID‐19

Ruiz-Hitzky

Darder

Wicklein

et al. 2020

Adv Healthcare Materials

144

134

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Dedicated to Dr. André Van Meerbeeck and to all the direct and indirect victims of the COVID-19 pandemic Researchers, engineers, and medical doctors are made aware of the severity of the COVID-19 infection and act quickly against the coronavirus SARS-CoV-2 using a large variety of tools. In this review, a panoply of nanoscience and nanotechnology approaches show how these disciplines can help the medical, technical, and scientific communities to fight the pandemic, highlighting the development of nanomaterials for detection, sanitation, therapies, and vaccines. SARS-CoV-2, which can be regarded as a functional core-shell nanoparticle (NP), can interact with diverse materials in its vicinity and remains attached for variable times while preserving its bioactivity. These studies are critical for the appropriate use of controlled disinfection systems. Other nanotechnological approaches are also decisive for the development of improved novel testing and diagnosis kits of coronavirus that are urgently required. Therapeutics are based on nanotechnology strategies as well and focus on antiviral drug design and on new nanoarchitectured vaccines. A brief overview on patented work is presented that emphasizes nanotechnology applied to coronaviruses. Finally, some comments are made on patents of the initial technological responses to COVID-19 that have already been put in practice.

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“…Additionally, triangular star-shaped bovine serum albumin (BSA)-coated tellurium NPs reportedly suppressed virus infection predominantly by obstructing the virus internalization procedure; these nanostars showed remarkable antiviral activities against porcine epidemic diarrhea virus (PEDV) (e.g., CoV) [62].…”

Section: Nanotechnology Against Viral Infections With Focus On Covsmentioning

confidence: 99%

Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses

et al. 2020

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Viral infections have recently emerged not only as a health threat to people but rapidly became the cause of universal fatality on a large scale. Nanomaterials comprising functionalized nanoparticles (NPs) and quantum dots and nanotechnology-associated innovative detection methods, vaccine design, and nanodrug production have shown immense promise for interfacing with pathogenic viruses and restricting their entrance into cells. These viruses have been scrutinized using rapid diagnostic detection and therapeutic interventional options against the caused infections including vaccine development for prevention and control. Coronaviruses, namely SARS-CoV, MERS-CoV, and SARS-CoV-2, have endangered human life, and the COVID-19 (caused by SARS-CoV-2) outbreak has become a perilous challenge to public health globally with huge accompanying morbidity rates. Thus, it is imperative to expedite the drug and vaccine development efforts that would help mitigate this pandemic. In this regard, smart and innovative nano-based technologies and approaches encompassing applications of green nanomedicine, bio-inspired methods, multifunctional bioengineered nanomaterials, and biomimetic drug delivery systems/carriers can help resolve the critical issues regarding detection, prevention, and treatment of viral infections. This perspective review expounds recent nanoscience advancements for the detection and treatment of viral infections with focus on coronaviruses and encompasses nano-based formulations and delivery platforms, nanovaccines, and promising methods for clinical diagnosis, especially regarding SARS-CoV-2.

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High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Abstract: Mercaptoethane sulfonate functionalised Te/BSA nanostars are prepared and exhibit excellent antiviral activity against arteriviruses and coronaviruses.

Cited by 29 publications

References 72 publications

Nanotechnology for virus treatment

Nanotechnology for virus treatment

Nanotechnology Responses to COVID‐19

Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses

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