High Atherogenic Index of Plasma Associated With Delayed Graft Function in Living Donor Renal Transplant Recipients: A Single‐Center Study in Vietnam

Abstract

PurposeTo determine the predictive value of the atherogenic index of plasma before transplant for delayed graft function.Patients and MethodsA cross‐sectional, longitudinal, non‐interventional, non‐controlled study of 167 patients undergoing kidney transplantation from living donors, with a mean age of 39.34 ± 11.86 years old, 53.3% male, and a pre‐transplant hemodialysis time of 14 (7–36) months. Delayed graft function was defined as decreased blood creatinine < 25% within the first 24 h compared to pre‐transplantation, and the patients needed hemodialysis in the first 7 days. The atherogenic index of plasma was calculated based on pre‐transplant plasma triglycerides and high‐density lipoprotein cholesterol concentrations.ResultsThe ratio of delayed graft function in renal transplant recipients from living donors was 13.8% (23/167 patients). Hemodialysis time, the ratio of hepatitis infection, overweight and obese, atherosclerosis, positive PRA, and acute rejection in the DGF (+) group were higher than those of the DGF (−) group, p < 0.05 and < 0.001. In particular, plasma CRP‐hs level and AIP also were higher in DGF (+) patients compared to those of DGF (−) ones, p < 0.001. Long hemodialysis time, obesity, high plasma CRP‐hs, and high AIP in pre‐transplant patients were independent factors related to DGF and had predictive value for DGF after kidney transplantation, in which AIP had good predictive value: AUC = 0.859, p < 0.001.ConclusionDelayed graft function was relatively common in renal transplant recipients from living donors. AIP before kidney transplant was a good predictor for delayed graft function.