High BANCR expression is associated with worse prognosis in human malignant carcinomas: an updated systematic review and meta-analysis

Abstract

Background BRAF-activated noncoding RNA (BANCR) is aberrantly expressed in various tumor tissues and has been confirmed to function as a tumor suppressor or oncogene in many types of cancers. Considering the conflicting results and insufficient sampling, a meta-analysis was performed to explore the prognostic value of BANCR in various carcinomas. Methods A comprehensive literature search of PubMed, Web of Science, EMBASE, Cochrane Library and the China National Knowledge Infrastructure (CNKI) was conducted to collect relevant articles. Results The pooled results showed a strong relationship between high BANCR expression and poor overall survival (OS) (HR (hazard ratio) =1.60, 95% confidence interval (CI): 1.19–2.15, P = 0.002) and recurrence-free survival (RFS) (HR = 1.53, 95% CI: 1.27–1.85, P < 0.00001). In addition, high BANCR expression predicted advanced tumor stage (OR (odds ratio) =2.39, 95% CI: 1.26–4.53, P = 0.008), presence of lymph node metastasis (OR = 2.03, 95% CI: 1.08–3.83, P = 0.03), positive distant metastasis (OR = 3.08, 95% CI: 1.92–4.96, P < 0.00001) and larger tumor sizes (OR = 1.63, 95% CI: 1.09–2.46, P = 0.02). However, no associations were found for smoking status (OR = 1.01, 95% CI: 0.65–1.56, P = 0.98), age (OR = 0.88, 95% CI: 0.71–1.09, P = 0.236) and sex (OR = 0.91, 95% CI: 0.72–1.16, P = 0.469). The sensitivity analysis of OS showed that the results of each publication were almost consistent with the combined results, and the merged results have high robustness and reliability. Conclusions The results showed that elevated BANCR expression was associated with unfavorable prognosis for most cancer patients, and BANCR could serve as a promising therapeutic target and independent prognostic predictor in most of cancer types.

ANRIL as a prognostic biomarker in colon pre-cancerous lesion detection via non-invasive sampling

“…In addition, Zhou and Gao (2016) described a key role for up-regulated BANCR in the occurrence and development of hepatocellular carcinoma and the prognosis of affected patients, proposing its application as an lncRNA biomarker for early diagnosis of cancer and prognosis screening. A recently published meta-analysis reported the association of an undesirable prognosis for most cancer patients with elevated BANCR expression (Fang et al, 2020). Sun et al (2016b) showed higher ANRIL expression in CRC tissue compared with adjacent non-tumour tissues.…”

Identification of Prognostic Model Based on Immune-Related LncRNAs in Stage I-III Non-Small Cell Lung Cancer

“…However, studies on BANCR and CRNDE function on tumor procession have shown conflicting results. For BANCR, some researchers have identified its influence in tumor invasion and migration ( 26 ). In contrast, overexpression of BANCR can control the content of N-cadherin, and vimentin and E-cadherin were shown to inhibit EMT in another study.…”

Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells

“…Subsequent evidence has demonstrated that the dysregulation of BANCR contributes to the progression of some cancers, including colorectal cancer, 24 papillary thyroid carcinoma, 25 bladder cancer, 26 T h i s c o n t e n t i s breast cancer, 22,27 endometrial cancer, 23 and hepatocellular carcinoma, 28 and increased BANCR expression causes poor prognosis and a shorter survival rate of cancer patients. 29 BANCR promotes cell proliferation of gastric cancer via the regulation of NF-kappaB1, 30 and lower expression of BANCR was related to the initiation and progression of non-small-cell lung cancer. 31 In eosinophilic esophagitis, BANCR is dysregulated and can be induced by IL-13 through the regulation of innate immune genes.…”

“…BANCR was first described as a cancer-promoting lncRNA in melanoma tissues in 2012, with a length of 693 bp and location on chromosome 9. Subsequent evidence has demonstrated that the dysregulation of BANCR contributes to the progression of some cancers, including colorectal cancer, papillary thyroid carcinoma, bladder cancer, breast cancer, , endometrial cancer, and hepatocellular carcinoma, and increased BANCR expression causes poor prognosis and a shorter survival rate of cancer patients . BANCR promotes cell proliferation of gastric cancer via the regulation of NF-kappaB1, and lower expression of BANCR was related to the initiation and progression of non-small-cell lung cancer .…”

“…A recent study showed that BANCR also participates in primate heart development . Therefore, BANCR is a lncRNA with important functions in the proliferation, migration, invasion, and apoptosis of cancer cells, and there is an increasing number of reports on the functions of BANCR in human diseases and tumorigenesis. , However, there have been no reports about the correlation between BANCR and CC to date, presenting a major obstacle for understanding the function and molecular mechanisms of BANCR in CC.…”