High baseline values of fat mass, independently of appendicular skeletal mass, predict 2- year onset of disability in elderly subjects at the high end of the functional spectrum

Zoico, Elena; Francesco, Vincenzo Di; Mazzali, Gloria; Zivelonghi, Alessandra; Volpato, Stefano; Bortolani, Arianna; Dioli, Andrea; Coin, Alessandra; Bosello, O; Zamboni, Mauro

doi:10.1007/bf03324682

Cited by 36 publications

(32 citation statements)

References 31 publications

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“…Data from other investigators suggest that the BMI cut‐point for increasing risk of disability may be lower than 35 kg·m −2 (22,29–31), particularly when outcomes involve tasks that require raising the centre of mass, e.g. ascending stairs (32). An interesting hypothesis is that the risk that added weight poses for physical disability may depend upon the demands of the task.…”

Section: Resultsmentioning

confidence: 99%

Obesity, intentional weight loss and physical disability in older adults

Rejeski¹,

Marsh²,

Chmelo³

et al. 2010

Obesity Reviews

109

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SummaryWe examine obesity, intentional weight loss, and physical disability in older adults. Based on prospective epidemiological studies, BMI exhibits a curvilinear relationship with physical disability; there appears to be some protective effect associated with older adults being overweight. Whereas the greatest risk for physical disability occurs in older adults who are ≥class II obesity, the effects of obesity on physical disability appears to be moderated by both sex and race. Obesity at age 30 constitutes a greater risk for disability later in life than when obesity develops at age 50 or later; however, physical activity may buffer the adverse effects obesity has on late life physical disability. Data from a limited number of randomized clinical trials (RCTs) reinforce the important role that physical activity plays in weight loss programs for older adults. Furthermore, short-term studies have found that resistance training may be particularly beneficial in these programs since this mode of exercise attenuates the loss of fat-free mass during caloric restriction. Multi-year RCTs are needed to examine whether weight loss can alter the course of physical disablement in aging and to determine the long-term feasibility and effects of combining resistance exercise with weight loss in older adults.

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Section: Resultsmentioning

confidence: 99%

Obesity, intentional weight loss and physical disability in older adults

Rejeski¹,

Marsh²,

Chmelo³

et al. 2010

Obesity Reviews

109

View full text Add to dashboard Cite

show abstract

“…with 14.5%) and women (31.7% compared with 14.6%) than in nonobese counterparts (16), with every SD increment of BMI associated with a 5% reduction in the usual walking speed (17). Likewise, several longitudinal studies suggested a link between elevated BMI and gait-speed decline (18)(19)(20)(21). Although previous longitudinal data reported a direct association between the amount of fat mass (12) and an inverse (13) [or null (22,23)] association between the amount of muscle mass and development of self-reported incident mobility limitation, to the best of our knowledge, this is the first article to address the independent association between changes in measures of body composition and gait speed.…”

Section: Figurementioning

confidence: 94%

Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study

Beavers¹,

Beavers²,

Houston³

et al. 2013

The American Journal of Clinical Nutrition

217

157

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“…The odds risk of chair-rise debility increases nearly 6-fold in severely obese persons when compared with those who are not obese, and the ability to complete multiple chair rises diminishes with increasing adiposity. 43 Obesity is related to a loss in stair ascent ability over time, 44 and obesity increases difficulty of performing other tasks such as climbing a stool, cutting toenails, squatting, rising from a supine position from the floor, kneeling, rising from a squat, picking up coins from the floor, and 1-legged stance. 45 In obese Japanese women, pain modulates the difficulty of performing daily movements such as walking more than an hour, sitting on the floor with legs beneath, and climbing stairs.…”

Section: Functional Effects Of Musculoskeletal Painmentioning

confidence: 99%

Musculoskeletal Pain, Fear Avoidance Behaviors, and Functional Decline in Obesity

Vincent

Adams

Vincent

et al. 2013

Regional Anesthesia and Pain Medicine

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Individuals with musculoskeletal pain exhibit abnormal movement patterns, including antalgic gait, postural dysfunction, increased thoracolumbar stiffness, decreased proprioception, and altered activation of abdominal and extensor muscles. Additionally, aberrant or increased biomechanical forces over time produce joint or structural damage that results in pain. A large body habitus resulting from excessive weight can accelerate these musculoskeletal complaints. Irrespective of age, obesity contributes to chronic musculoskeletal pain, impairment of mobility, and eventual physical disability. Potential mechanisms that may mediate the relationships between obesity-related pain and functional decline include skeletal muscle strength deterioration, systemic inflammation, and psychosocial characteristics (eg, pain catastrophizing, kinesiophobia, and depression). Treatment considerations for obese patients with musculoskeletal pain include assessment of kinesiophobia levels, biomechanical analysis, and pain medication use. Ideally, a multidisciplinary team of physicians, psychologists, and physical therapists should optimize the design of interventions specific to the patient. In some cases, the use of appropriate pain medications or intra-articular injectable agents may help control pain, fostering sustained activity, caloric expenditure, and weight loss. Morbid obesity is a medical condition that alters biomechanical forces on the tissues of the body. This condition provides the opportunity to examine accelerated development of musculoskeletal pain syndromes and etiology. The proposed therapeutic interventions can have multiple benefits in the obese population including weight loss, improved psychological outlook and self-efficacy, reduced kinesiophobia levels, reduced risk of functional dependence, and improved quality of life.

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High baseline values of fat mass, independently of appendicular skeletal mass, predict 2- year onset of disability in elderly subjects at the high end of the functional spectrum

Cited by 36 publications

References 31 publications

Obesity, intentional weight loss and physical disability in older adults

Obesity, intentional weight loss and physical disability in older adults

Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study

Musculoskeletal Pain, Fear Avoidance Behaviors, and Functional Decline in Obesity

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