High bladder cancer mortality in rural New England (United States): An etiologic study

Brown, Linda Morris; Zahm, Shelia Hoar; Hoover, Robert N.; Fraumeni, Joseph F.

doi:10.1007/bf00051412

Cited by 37 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include four cohort studies conducted in the US (Mills et al, 1991;Chyou et al, 1993), Norway (Stensvold and Jacobsen, 1994), and the Netherlands (Zeegers et al, 2001a) ( With reference to case-control design, 17 further studies were published between 1990 and 2007 (Clavel and Cordier, 1991;Nomura et al, 1991;D'Avanzo et al, 1992; Kunze et al, 1992;Escolar Pujolar et al, 1993;McGeehin et al, 1993;Vena et al, 1993;Momas et al, 1994;Brown et al, 1995;Bruemmer et al, 1997;Donato et al, 1997;Pohlabeln et al, 1999;Geoffroy-Perez and Cordier, 2001;Woolcott et al, 2002;Radosavljevic et al, 2003;Wakai et al, 2004;De Stefani et al, 2007) (Table 3). An investigation Population-based 219 : 794 men 1 (reference) < 365 lifelong cups Allowance for variables showing significant influence on risk of bladder cancer in the study 1.6 (0.6-3.8) 365-25 000 cups 1.6 (0.6-3.8) 25,001-60 000 cups 4.1 (1.7-10.0) > 60 000 cups from France, including 765 cases and 765 matched controls, found ORs of 1.4 (95% CI, 0.9-2.1) for men and 0.7 (95% CI, 0.3-2.0) for women at the highest level of coffee consumption, compared with the lowest level (Geoffroy-Perez and Cordier, 2001).…”

Section: Coffee Consumptionmentioning

confidence: 98%

Alcohol, coffee, and bladder cancer risk: a review of epidemiological studies

Pelucchi

Vecchia

2009

European Journal of Cancer Prevention

View full text Add to dashboard Cite

The objective was to review epidemiological studies that evaluated the association between consumption of coffee and alcohol and urinary bladder cancer. We searched the Medline database for observational studies of bladder neoplasms that included information on coffee or alcohol drinking, and looked for papers quoted as references in reviews of risk factors for bladder cancer and in studies that had been selected for inclusion. Results from epidemiological studies allow excluding a strong association between coffee and bladder cancer. Several studies reported a moderate increase in risk in coffee drinkers as compared with nondrinkers, but no trend with dose has been established. Epidemiological data on alcohol drinking and bladder cancer are suggestive of no association, although findings were not always consistent. For both habits, an explanation of the moderate increase in risk observed in some investigations might be attributed to residual confounding by smoking, or to an association between alcohol, coffee, and yet unidentified risk factors for bladder cancer.

show abstract

Section: Coffee Consumptionmentioning

confidence: 98%

Alcohol, coffee, and bladder cancer risk: a review of epidemiological studies

Pelucchi

Vecchia

2009

European Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…2 Interestingly, there is marked urban-rural difference in the incidence rates of bladder cancer, and in the U.S., there is a striking persistence of elevated mortality rates in New England that remains etiologically obscure. 6 The most frequently documented somatic genetic alteration in bladder cancer is in the TP53 gene, with the prevalence of alterations reported varying from 14% 10 to 61% 7 with the populationbased series reporting lower prevalence rates. Most studies of TP53 alteration have been derived from relatively small, hospitalbased series, [8][9][10][11][12] capturing higher stage patients undergoing surgery for their disease.…”

mentioning

confidence: 99%

TP53 alterations and patterns of carcinogen exposure in a U.S. population‐based study of bladder cancer

Kelsey

Hirao

et al. 2005

Intl Journal of Cancer

View full text Add to dashboard Cite

The molecular pathology of bladder cancer has been the subject of considerable interest, and current efforts are targeted toward elucidating the interrelationships between individual somatic gene loss and both etiologic and prognostic factors. Mutation of the TP53 gene has been associated with more invasive bladder cancer, and evidence suggests that TP53 mutation, independent of stage, may be predictive of outcome in this disease. However, there is no consensus in the literature that bladder carcinogen exposure is associated with inactivation of the TP53 gene. Work to date has been primarily hospital based and, as such, subject to possible bias associated with selection of more advanced cases for study. We examined exposure relationships with both TP53 gene mutation and TP53 protein alterations in a population-based study of 330 bladder cancer cases in New Hampshire. Tobacco smoking was not associated with TP53 alterations. We found a higher prevalence of TP53 inactivation (i.e., mutation and nuclear accumulation) among hair dye users (odd ratio [OR] 5 4.1; 95% confidence interval [CI] 1.2-14.7), and the majority of these mutations were transversions. Men who had ''at risk'' occupations were more likely to have mutated TP53 tumors (OR 5 2.9; 95% CI 1.1-7.6). There also was a relative absence of TP53 mutation (OR 5 0.4; 95% CI 0.0-2.9) and TP53 protein alterations (OR 5 0.6; 95% CI 0.3-1.4) in bladder cancers from individuals with higher arsenic exposure. Our data suggest that there is exposure-specific heterogeneity in inactivation of the TP53 pathway in bladder cancers and that integration of the spectrum of pathway alterations in population-based approaches (capturing the full range of exposures to bladder carcinogens) may provide important insights into bladder tumorigenesis. ' 2005 Wiley-Liss, Inc.

show abstract

“…These boundaries de®ne the geographic extent of areas with high mortality. Brown et al (1995) conducted an etiologic study of bladder cancer that used mortality maps to identify the study population. Other areas of potential application include air pollution and respiratory illness (Bates and Sizto 1983;Bu¿er 1988;Bates et al 1990;Dockery et al 1993), environmental risk factors and cancers (Najem et al 1985;Carpenter and Beresford 1986;Jacquez and Kheifets 1993), and agricultural and industrial exposures and cancer (Blot and Fraumeni 1977;Matanoski 1981;Stokes and Brace 1988;Linos et al 1991;Nuckols et al 1996).…”

Section: Review Of Applicationsmentioning

confidence: 99%

From fields to objects: A review of geographic boundary analysis

Jacquez¹,

Maruca²,

2000

View full text Add to dashboard Cite

Geographic boundary analysis is a relatively new approach unfamiliar to many spatial analysts. It is best viewed as a technique for de®ning objects ± geographic boundaries ± on spatial ®elds, and for evaluating the statistical signi®cance of characteristics of those boundary objects. This is accomplished using null spatial models representative of the spatial processes expected in the absence of boundary-generating phenomena. Close ties to the object-®eld dialectic eminently suit boundary analysis to GIS data. The majority of existing spatial methods are ®eld-based in that they describe, estimate, or predict how attributes (variables de®ning the ®eld) vary through geographic space. Such methods are appropriate for ®eld representations but not object representations. As the object-®eld paradigm gains currency in geographic information science, appropriate techniques for the statistical analysis of objects are required. The methods reviewed in this paper are a promising foundation. Geographic boundary analysis is clearly a valuable addition to the spatial statistical toolbox. This paper presents the philosophy of, and motivations for geographic boundary analysis. It de®nes commonly used statistics for quantifying boundaries and their characteristics, as well as simulation procedures for evaluating their signi®cance. We review applications of these techniques, with the objective of making this promising approach accessible to the GIS-spatial analysis community. We also describe the implementation of these methods within geographic boundary analysis software: GEM.

show abstract

High bladder cancer mortality in rural New England (United States): An etiologic study

Cited by 37 publications

References 13 publications

Alcohol, coffee, and bladder cancer risk: a review of epidemiological studies

Alcohol, coffee, and bladder cancer risk: a review of epidemiological studies

TP53 alterations and patterns of carcinogen exposure in a U.S. population‐based study of bladder cancer

From fields to objects: A review of geographic boundary analysis

Contact Info

Product

Resources

About