High Blood-Pressure and Cancer ?

Gillis, Garry; Hole, David; MacLean, Duncan S.; Hawthorne, Victor M.; Watt, H. James; Watkinson, G.

doi:10.1016/s0140-6736(75)90208-1

Cited by 14 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several epidemiological studies have investigated hypertension as a significant risk factor for cancer [39,40,41,42,43,44,45], but the results of these studies have been inconsistent. Some studies have reported an increased risk of cancer mortality in hypertensive populations [39,40], whereas others have reported no association [42,43,44].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Kidney Disease in Cancer Patients: An Independent Predictor of Cancer-Specific Mortality

Na¹,

Sung²,

Chang³

et al. 2011

Am J Nephrol

View full text Add to dashboard Cite

Background/Aims: The effects of chronic kidney disease (CKD) on the risk of death for patients with malignant disease are uncertain. The aim of this study was to determine the association between the presence of CKD and mortality in cancer patients. Method: We retrospectively reviewed the cases of 8,223 cancer patients with one or more serum creatinine measurements from January 1, 2000 to December 31, 2004. The key outcome was cancer-specific mortality within the follow-up period. The cumulative incidence rate for death from cancer was estimated using methods of competing risks survival analysis. Cox proportional-hazards regression with the use of Fine and Gray’s proportional-hazards model were evaluated in multiple analyses. Results: CKD was associated with an increased risk of death in cancer patients. The adjusted hazard ratios were 1.12 for patients with an estimated glomerular filtration rate (eGFR) of 30–59 ml/min/1.73 m² (95% confidence interval 1.01–1.26, p = 0.04) and 1.75 for patients with an eGFR <30 ml/min/1.73 m² (95% confidence interval 1.32–2.32, p < 0.001). Conclusions: CKD should be considered a risk factor for survival among patients with cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported an increased risk of cancer mortality in hypertensive populations [39,40], whereas others have reported no association [42,43,44]. In most studies, the relationship of cancer mortality with blood pressure was dependent on the time of follow-up from the initial measurement.…”

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease in Cancer Patients: An Independent Predictor of Cancer-Specific Mortality

Na¹,

Sung²,

Chang³

et al. 2011

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…Elevated blood pressure or hypertension has not been consistently associated with cancer incidence or mortality (35,36). Calcium and vitamin D deficiencies might lead to both elevated blood pressure and colorectal cancer (37)(38)(39), resulting in a positive association, although not necessarily a causal one.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Abnormalities and Risk for Colorectal Cancer in the Physicians' Health Study

Stürmer

Buring

Lee³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

115

View full text Add to dashboard Cite

Background: Obesity and diabetes are established risk factors for colorectal cancer but have mainly been assessed independently. There are few data about whether the metabolic syndrome, which refers to a clustering of cardiovascular disease risk factors thought to be related to insulin resistance, including obesity, type 2 diabetes, hyperlipidemia, and hypertension, is associated with colorectal cancer risk. Methods: During and after the randomized trial of aspirin and B-carotene, 22,071 healthy male physicians, initially ages 40 to 84 years, reported overweight (body mass index, z27 kg/m

show abstract

“…Several prospective epidemiologic studies have investigated whether hypertension is a significant risk factor for cancer [1,2,6,15,16], although the results of these studies have been inconsistent. Some investigators have hypothesized that hypertension by itself may be a risk factor for kidney cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Even in the case of studies that have reported a positive association between hypertension and a particular type of cancer [1,3,6,16,18,19], the results have been criticized because of small sample sizes and short follow-up periods.…”

Section: Discussionmentioning

confidence: 99%