High blood pressure and overweight in children with Legg-Calvé-Perthes disease: a nationwide population-based cohort study

Mörlin, Gabriella B.; Hailer, Yasmin D.

doi:10.1186/s12891-020-03889-9

Cited by 9 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…both at the time of diagnosis and in adulthood, [5][6][7][8][9] which differs from the traditional description of a child who is small and thin. It remains unclear whether the increased prevalence of overweight/obesity in children with LCPD is attributed to concomitant conditions, pain, or an iatrogenic effect of a treatment such as restrictions on physical activity levels.…”

mentioning

confidence: 77%

“…[14][15][16] Families commonly express concern about weight gain that may occur subsequent to prolonged durations of non-weight bearing and physical activity restrictions. These concerns of weight gain and obesity are supported by cross-sectional 5,7,8 and longitudinal studies 9 revealing a high prevalence of overweight and obese children with LCPD.…”

mentioning

confidence: 92%

“…Childhood overweight and obesity remain a significant public health concern worldwide,1 with risk factors including physical inactivity and unhealthy eating patterns 2–4. In Legg-Calvé-Perthes Disease (LCPD), the prevalence of overweight and obesity is reportedly high both at the time of diagnosis and in adulthood,5–9 which differs from the traditional description of a child who is small and thin. It remains unclear whether the increased prevalence of overweight/obesity in children with LCPD is attributed to concomitant conditions, pain, or an iatrogenic effect of a treatment such as restrictions on physical activity levels 10…”

mentioning

confidence: 99%

See 2 more Smart Citations

Do Weightbearing Restrictions Cause Excess Weight Gain in Children With LEGG-Calvé-Perthes Disease?

Novotny

Hailer

Laine

et al. 2022

Journal of Pediatric Orthopaedics

Self Cite

View full text Add to dashboard Cite

Background: Restricted weight bearing is commonly prescribed in Legg-Calvé-Perthes Disease (LCPD), raising concerns of causing overweight or obesity. This study utilizes prospectively collected data to address the following questions: (1) does body mass index (BMI) Z-score increase over the course of LCPD follow-up; (2) is having a BMI category of normal, overweight, or obese at baseline associated with BMI Z-score changes over the course of follow-up; and (3) is the duration of weight bearing restrictions (no restrictions, <3, 3 to <6, 6 to 9, or > 9 mo) associated with BMI Z-score changes. Methods: Data of 130 children aged 5 to 12 years with unilateral early-stage LCPD were extracted from an international database. Nation-specific BMI Z-scores and percentile-based weight categories were determined, and the duration of follow-up and weight bearing restrictions were calculated. Longitudinal changes in BMI Z-scores were evaluated for the 3 study questions using mixed effects linear regression models with surgery as a covariate. Sensitivity analyses were used to determine the influence of socio-cultural background (USA vs. India) for each study question. Results: During the 35.5 ± 15.9 months of follow-up, no statistically significant increase in BMI Z-scores was observed across the entire cohort, or following stratification by baseline weight categories or the duration of the weight bearing restriction. Sensitivity analyses indicated that patients in the USA had no change in their BMI Z-score. When stratified by weight categories, the normal weight of US children had a small increase in their BMI Z-score (0.005 per mo, 95% confidence interval: 0.0002, 0.009), but this was not seen in other BMI categories. The cohort of Indian children had a small but significant decrease in their BMI Z-score (−0.005/mo, 95% CI: −0.009, −0.0002). After stratification by weight categories, a small decrease of the BMI Z-score was observed only in the Indian overweight children (−0.016 per mo, 95% CI: −0.027, −0.005) and no other BMI category. Conclusions: Weightbearing restrictions over the course of follow-up for our cohort of children with early-stage LCPD were not associated with clinically meaningful increases of BMI Z-scores. Weight gain is multi-factorial and probably not caused by weight bearing restrictions alone.

show abstract

mentioning

confidence: 77%

mentioning

confidence: 92%

mentioning

confidence: 99%

See 1 more Smart Citation

Do Weightbearing Restrictions Cause Excess Weight Gain in Children With LEGG-Calvé-Perthes Disease?

Novotny

Hailer

Laine

et al. 2022

Journal of Pediatric Orthopaedics

Self Cite

View full text Add to dashboard Cite

show abstract

“…[13][14][15] Moreover, high rates of obesity and hypertension were also identified in a group of children having LCPD. [16] The cause of the LCPD is largely unknown, though, many experimental and clinical studies provide support to the idea that the temporary disruption of the blood supply to the femoral head is a key event in the pathogenesis of the disease. Various diagnostic tools including selective angiography, [17] bone scintigraphy, [18] perfusion magnetic resonance imaging (MRI), [19] and the biopsy studies [20] from the early stages of the disease show clear indication of disruption of perfusion and bone damage consistent with AVN.…”

Section: Etiology Of Lcpdmentioning

confidence: 99%

Clinical and genetic characteristics of Legg-Calve-Perthes disease

Basit¹,

Khoshhal

2021

JMSR

View full text Add to dashboard Cite

Legg-Calve-Perthes disease (LCPD) is a known childhood form of idiopathic femoral head osteonecrosis. It is characterized by a sequence of events involving the capital femoral epiphysis. The disease process is associated with the disruption of the blood supply to the femoral head. In most cases, LCPD appears in a sporadic form. Occurrences of cases in families have also been reported, with some families having more than two affected individuals. The disease etiology is still unknown, however, various factors have been considered for the pathogenesis of LCPD, including very low body weight or short stature at birth, maternal smoking, and secondhand smoke exposure. Interaction of multiple environmental and genetic factors has also been postulated as an underlying player in the development of the disorder. Hypercoagulability may have a major role in LCPD development. Families segregating LCPD largely demonstrate autosomal dominant inheritance. Variants in coagulations genes (Factor 5 and Factor 2) and collagen encoding gene (COL2A1) have been linked to the disease. However, our knowledge of the LCPD pathogenic factors is limited. A better understanding of the association between LCPD and causative factors, for example, the role of hypercoagulability in osteonecrosis development, might lead to the development of improved treatments, to shorten the acute phase of the disease during childhood as well as to possibly reduce the long-term effects of osteoarthritis in adulthood. Detection of large-effect variants underlying LCPD may help in offering extended screening for all first-degree family members. In this review, we would like to discuss the etiological factors underlying LCPD with special emphasis on the role of coagulation factors and mutations in the genes encoding those coagulation factors.

show abstract

“…Perthes disease, also known as Legg-Calve-Perthes disease (LCPD), is characterized by necrosis of the femoral head which results from interruption of blood supply to the femoral head in the pediatric population (Mörlin and Hailer, 2021). Although certain genetic components have been reported as contributing factors, its etiology remains elusive (Rodríguez-Olivas et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Perthes Disease in a Child With Osteogenesis Imperfecta From a Rare Genetic Variant: A Case Report

et al. 2022

View full text Add to dashboard Cite

Background: Although certain genetic components have been reported as contributing factors for Perthes disease, its etiology remains unclear. We present a rare case of Perthes disease in a child with osteogenesis imperfecta (OI) caused by a mutation in the COL1A1 gene (NM_000088):exon25:c.1726C>T, (p.Gln576X).Case presentations: A 7-year-old boy was initially treated at our medical facility in March 2016 with a history of chronic pain in right hip joint and limping for a year. He was diagnosed as Perthes disease in the right hip joint. He underwent acetabular osteotomy and ipsilateral proximal femoral varus osteotomy for better containment. During the follow-ups, the right hip demonstrated a normal range of motion without pain, and the pelvic X-ray demonstrated Stulberg Type II hip joint with a round femoral head. In the latest admission in 2022, he suffered from a right femoral shaft fracture after petty violence. After reviewing his medical history, he was suspected of having OI. The whole exome sequencing demonstrated a gene mutation in COL1A1 (OMIM 166200) and confirmed the diagnosis of OI. Telescopic nailing was used to treat the femoral shaft fracture. After the nailing of the right femur, the appearance of the lower extremity seemed normal and symmetrical.Conclusion: This study revealed that there might be an association between OI and Perthes disease. Our case report enriches the phenotypes of osteogenesis imperfecta and provides insight into the pathogenesis of LCPD.

show abstract

High blood pressure and overweight in children with Legg-Calvé-Perthes disease: a nationwide population-based cohort study

Cited by 9 publications

References 30 publications

Do Weightbearing Restrictions Cause Excess Weight Gain in Children With LEGG-Calvé-Perthes Disease?

Do Weightbearing Restrictions Cause Excess Weight Gain in Children With LEGG-Calvé-Perthes Disease?

Clinical and genetic characteristics of Legg-Calve-Perthes disease

Perthes Disease in a Child With Osteogenesis Imperfecta From a Rare Genetic Variant: A Case Report

Contact Info

Product

Resources

About