High blood uric acid is associated with reduced risks of mild cognitive impairment among older adults in China: a 9-year prospective cohort study

Chen, Chen; Lv, Yuebin; Yin, Zhaoxue; Zhao, Feng; Liu, Yingchun; Li, Chengcheng; Ji, Saisai; Zhou, Jinhui; Wei, Yuan; Cao, Xingqi; Wang, Jiaonan; Gu, Heng; Lü, Feng; Liu, Zuyun; Shi, Xiaoming

doi:10.1101/2021.07.24.21261062

Cited by 1 publication

(2 citation statements)

References 43 publications

(48 reference statements)

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“…Moreover, epidemiological data have indicated an inverse association between UA and several neurological disorders. An emerging body of evidence has indicated that lower SUA levels are associated with poorer cognitive function and increased risk of mild cognitive impairment [12,18]. Furthermore, a decreased SUA level is related to a markedly higher risk of progressing to Alzheimer's disease dementia from a non-demented state [19,20], and the development of nonmotor symptoms in patients with Parkinson's disease [10].…”

Section: Discussionmentioning

confidence: 99%

“…Uric acid (UA) is a natural antioxidant, and reportedly has a neuroprotective impact in various neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, and multiple sclerosis [8][9][10]. Its antioxidant properties may protect against the detrimental effect of oxidative stress in people with central nervous system disorders [10][11][12]. However, it is unclear whether lower preoperative serum UA (SUA) levels are associated with the development of POD in older patients following hip fracture surgery.…”

Section: Introductionmentioning

confidence: 99%

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Lower preoperative serum uric acid level may be a risk factor for postoperative delirium in older patients undergoing hip fracture surgery: a matched retrospective case-control study

Lyu

Wei

et al. 2022

BMC Anesthesiol

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Background Postoperative delirium (POD) is a common complication after hip fracture surgery that is associated with various short- and long-term outcomes. The mechanism of POD may be associated with the oxidative stress process. Uric acid has been shown to provide a neuroprotective effect in various neurodegenerative diseases through its antioxidant properties. However, it is unclear whether lower preoperative serum uric acid levels are associated with the development of POD after hip fracture surgery. Therefore, this study assessed the association of lower preoperative uric acid levels in patients with POD during hospitalization. Methods This is a matched retrospective case-control study that included 96 older patients (≥65 y) who underwent hip fracture surgery. POD was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Patients diagnosed with POD (cases) were matched 1:1 with patients without POD (controls) on the basis of age, sex, and anesthesia type. The relationship between preoperative uric acid and POD was analyzed by multivariable analysis. Results The POD and non-POD groups each had 48 patients. In the univariate analysis, lower log preoperative serum uric acid value, higher neutrophil-to-lymphocyte ratio, and cerebrovascular disease were more likely in patients with POD than in those with no POD. Multivariable conditional logistic regression analysis showed that lower log preoperative serum uric acid (adjusted odds ratio [aOR], 0.028; confidence interval [CI], 0.001–0.844; p = 0.040), higher neutrophil-to-lymphocyte ratio (aOR, 1.314; 95% CI, 1.053–1.638; p = 0.015), and increased surgery duration (aOR, 1.034; 95% CI, 1.004–1.065; p = 0.024) were associated with increased risk of POD. Conclusions Lower preoperative serum uric acid levels may be an independent risk factor for POD after adjustment for possible confounding factors. However, large prospective studies are needed to confirm this finding.

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