High Body Mass Index (BMI) Is Associated with Lower Survival and Increased Chronic GVHD after Allogeneic Hematopoietic Stem Cell Transplantation.

Asslan, Mona; El-Sheikh, Ebaa Hussein; Taha, Atef; Abdelraouf, Yasser M; Kabbash, Ibrahim Ali; Baker, K. Scott; Gooley, Ted; Mahmoud, Hossam K.; Fattah, Raafat Abd El

doi:10.1016/j.bbmt.2018.12.519

Cited by 4 publications

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“…However, high BMI (35 kg/m 2 ) may be associated with the risk of overnutrition, and nutritional interventions should be considered accordingly. 19 These results are consistent with those of a meta-analysis of studies on the impact of BMI on allo-HSCT outcomes. 20 In the present study, GNRI was associated with survival outcomes.…”

Section: Discussionsupporting

confidence: 89%

Impact of Body Mass Index on 5-Year Survival Rates in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Aoyama

Notsu

Ichimaru

et al. 2022

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Background: Cancer survival is associated with body mass index (BMI). However, the impact of patients’ baseline characteristics on allogeneic hematopoietic stem cell transplantation (allo-HSCT) outcomes remains unclear. This study aimed to examine the baseline clinical factors associated with 5-year survival rates in patients undergoing allo-HSCT. Material and Methods: This was a retrospective exploratory observational study. Patients (n = 113, 52 women; average age: 55 years) who underwent allo-HSCT at the Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, between January 2008 and March 2015, were included in the present study. Results: Patients with low BMI (<18.5 kg/m2) had significantly lower 5-year survival rates than those with normal (18.5-24.9 kg/m2) and high (⩾25.0 kg/m2) BMI. The 5-year survival rate was poorer for patients with sarcopenia (41.5%) than that for those without sarcopenia prior to allo-HSCT ( P = .05). The 5-year survival rate was poorer for patients with geriatric nutritional risk index (GNRI < 98) (34.5%) than that for those without GNRI prior to allo-HSCT ( P < .01). Conclusions: Low BMI before allo-HCST pre-treatment was a predictor of 5-year survival rates in this study. Patients undergoing allo-HSCT may require nutritional interventions during pre-treatment to reduce the risk of sarcopenia and GNRI (<98), which affects their survival rates.

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Section: Discussionsupporting

confidence: 89%