High Bone Mineral Density of the Lumbar Spine Is Positively Associated with Breast Cancer

Vaz-Gonçalves, Larissa; Martins, Karine Anusca; Godinho-Mota, Jordana Carolina Marques; Schincaglia, Raquel Machado; Sousa, Ana Luíza Lima; Freitas‐Junior, Ruffo

doi:10.1155/2019/8010356

Cited by 3 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the random effects of the model showed that women who reported breast cancer during follow-up visits had higher BMD at baseline than women who remained free of breast cancer. This is consistent with other research findings associating high BMD with the risk of breast cancer [1][2][3][4]. Furthermore, women who reported breast cancer lost BMD at a faster rate throughout the follow-up periods, eventually descending to lower BMD levels than those of women free of breast cancer.…”

Section: Discussionsupporting

confidence: 92%

“…Also in 2013, a retrospective study of Israeli women found an association between breast cancer and higher BMD in the lumbar spine, femoral neck, and total hip [3]. A more recent case-control study in 2019 confirmed that breast cancer in Brazilian women was associated with high BMD in the lumbar spine, but not in the femoral neck or total femur [4]. Interestingly, a 2022 case-control study reported that BMD in women with breast cancer was higher compared with those in a control group, even though the breast cancer cases had lower average vitamin D levels, which are normally associated with bone health [1].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

Brown,

Bigelow,

Dubin

2023

Cancers

View full text Add to dashboard Cite

Breast cancer is associated with phosphate toxicity, the toxic effect from dysregulated phosphate metabolism that can stimulate tumorigenesis. Phosphate toxicity and dysregulated phosphate metabolism are also associated with bone mineral abnormalities, including excessive bone mineral loss and deposition. Based on shared associations with dysregulated phosphate metabolism and phosphate toxicity, a hypothesis proposed in the present mixed methods–grounded theory study posits that middle-aged women with incidence of breast cancer had a greater magnitude of changes in bone mineral density over time compared with women who remained cancer-free. To test this hypothesis, a mixed-effects model was used to analyze the associations of breast cancer incidence with spinal bone mineral density changes in the U.S. Study of Women’s Health Across the Nation. Compared with women in the cohort who remained cancer-free, women who self-reported breast cancer had higher bone mineral density at baseline, but had more rapid losses in bone mineral density during follow-up visits. These findings agree with the hypothesis that a greater magnitude of changes in bone mineral density over time is associated with breast cancer in a cohort of middle-aged women. The findings also have implications for studies investigating dysregulated phosphate metabolism and phosphate toxicity as causative factors of bone metastasis in metastatic breast cancer. Additionally, the authors previously found increased breast cancer risk associated with high dietary phosphate intake in the same cohort of middle-aged women, and more studies should investigate a low-phosphorus diet to reduce bone mineral abnormalities and tumorigenesis in breast cancer patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

Brown,

Bigelow,

Dubin

2023

Cancers

View full text Add to dashboard Cite

show abstract

“…In several observational studies, women newly diagnosed with breast cancer, prior to any antitumor therapy, have been found to have higher BMD than women without breast cancer, and BMD is positively correlated with the incidence of breast cancer. High BMD is considered a biomarker of breast cancer risk [38][39][40] . However, bone mineral density was not found to be a risk factor for breast cancer in ourr MR Study.…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization analyses of associations between breast cancer and bone mineral density

Wang

Liu

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The purpose of this study was to verify whether there is a causal relationship between breast cancer and bone mineral density (BMD). Summary statistics for exposures and outcomes were obtained from corresponding genome-wide association studies. The bidirectional and multivariate mediated Mendelian randomization (MR) analyses were performed. In the bidirectional MR analysis, breast cancer might reduce the BMD of the heel (HE-BMD) (FDR = 1.51 × 10−4) as might its ER+ subtype (FDR = 1.51 × 10−4). From BMD to breast cancer, no significant association was found (FDR > 0.05). The mediating MR analysis showed that Higher free testosterone (FT) only mediated the causal relationship between breast cancer and HE-BMD by 2.9%; both ER+ type and FT were independent factors of HE-BMD (ER+: P = 0.021; FT: P = 6.88 × 10−6). Higher FT could increase the risk of breast cancer (FDR = 1.21 × 10−3) as could total testosterone (TT) (FDR = 5.81 × 10−3). Similarly, higher FT could increase the risk of ER+ subtype (FDR = 2.51 × 10−6) as could TT (FDR = 5.55 × 10−4). These results indicate that BMD is not a risk factor for breast cancer but breast cancer and its ER+ subtype are risk factors for BMD loss. Furthermore, higher FT and TT levels are associated with both an increased incidence of breast cancer and increased bone density.

show abstract

“…For the growth and maturation of bone estrogen is considered to be an important factor and in adults, it also helps in the regulation of bone turnover [70]. Estrogen exerts a protective effect on bone as estrogen receptors are found on osteoblasts and osteoclasts; thus the tissue of bone is responsive to estrogen [71].…”

Section: Effect Of Estrogen On Skeletal Integrity: Molecular Mechanismmentioning

confidence: 99%

A Review: Mechanistic Insights Into the Effect of Thyroid Disorders on Estrogen Level and Bone Mineral Density

Joshi

Bisht

Singh

2019

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Thyroid hormone serves as an indispensable component for the optimum functioning of various biological systems. They curb body’s metabolism, regulates the estrogen level, regulates bone turnover, essential for skeletal development and mineralization. Within the scope of knowledge, it is intimately familiar that thyroid disorders have widespread systemic manifestations, among which in hypothyroidism, even though elevated TSH (thyroid-stimulating hormone) may reduce estrogen level which in turn stimulates osteoclasts and thus cause osteoporosis, while hyperthyroidism accelerates bone turnover. Hypothyroidism does not directly interfere with the skeletal integrity, but treatment with levothyroxine for the suppression of TSH to bring the hypothyroid patient to euthyroid state for a long haul; lead to simultaneous reduction in bone mass and in (bone mineral density) BMD. After the initial relevation of the correlation between thyroid disorders and osteoporosis in numerous studies have emphasized that both hypo and hyperthyroidism either directly or indirectly affects the bone mineral density or leads to the progression of osteoporosis. Therefore the present study is aimed and so designed to review all the possible associations between them and the impact of thyroid disorders on estrogen level and bone mineral density. The main findings of this review indicate that both excesses as well as deficiency of thyroid hormone can be potentially deleterious for bone tissue.

show abstract

High Bone Mineral Density of the Lumbar Spine Is Positively Associated with Breast Cancer

Cited by 3 publications

References 44 publications

Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

Mendelian randomization analyses of associations between breast cancer and bone mineral density

A Review: Mechanistic Insights Into the Effect of Thyroid Disorders on Estrogen Level and Bone Mineral Density

Contact Info

Product

Resources

About