High capacity production of &gt;65% spin polarized xenon-129 for NMR spectroscopy and imaging

Zook, Anthony L; Adhyaru, Bhavin; Bowers, Clifford R.

doi:10.1016/s1090-7807(02)00030-7

Cited by 112 publications

(125 citation statements)

References 23 publications

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“…Figure 8b compares the experimental lineshape with a simulation using Eqs. (17) and (27). The lineshapes agree qualitatively, which shows that the model presented in section 2 is adequate to describe the observed signal.…”

Section: Tube In a Tube Experimentssupporting

confidence: 57%

“…While P S is given by the Boltzmann law, which is P S = |γ S | B 0 /2kT within the high temperature approximation, the polarization P I of the 129 Xe is determined by the efficiency of the spin-exchange optical pumping process and can exceed 0.5 under optimum conditions [27].…”

Section: Signal In a Ddf Experimentsmentioning

confidence: 99%

“…The data along the indirect dimension was analyzed by fitting Eq. (27). The product of the inverse of this function with an exponential decay with time constant τ = 24 ms was used to apodize the data along t 1 before the Fourier transform.…”

Section: Xe In Solutionmentioning

confidence: 99%

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NMR detection using laser-polarized xenon as a dipolar sensor

Granwehr

Urban

Trabesinger

et al. 2005

Journal of Magnetic Resonance

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Hyperpolarized 129 Xe can be used as a sensor to indirectly detect NMR spectra of heteronuclei that are neither covalently bound nor necessarily in direct contact with the Xe atoms, but coupled through long-range intermolecular dipolar couplings. In order to reintroduce long-range dipolar couplings the sample symmetry has to be broken. This can be done either by an asymmetric sample arrangement, or by breaking the symmetry of the spin magnetization with field gradient pulses. Experiments are performed where only a small fraction of the available 129 Xe magnetization is used for each point, so that a single batch of xenon suffices for the point-by-point acquisition of a heteronuclear NMR spectrum. Examples with 1 H as analyte nucleus show that these methods have the potential to obtain spectra with a resolution that is high enough to determine homonuclear J couplings. The applicability of this technique with remote detection is discussed.

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Section: Tube In a Tube Experimentssupporting

confidence: 57%

Section: Signal In a Ddf Experimentsmentioning

confidence: 99%

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NMR detection using laser-polarized xenon as a dipolar sensor

Granwehr

Urban

Trabesinger

et al. 2005

Journal of Magnetic Resonance

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“…However, the tendency of xenon to form spinrotation interactions with other Xe atoms and its solubility in cell surface coatings increases the efficiency of spin-lattice relaxation and makes the polarization and transport processes more challenging (40). The state of the art Xe-129 polarization method uses continuous flow spin-exchange polarization systems in combination with high powered (40 -200 W) lasers (41,42). In this method, depolarization is reduced by freezing the polarized nuclei in the solid state using a liquid N 2 cold finger (43,44).…”

Section: Hyperpolarized Gas Agentsmentioning

confidence: 99%

Functional lung imaging using hyperpolarized gas MRI

Fain

Korosec

Holmes

et al. 2007

Magnetic Resonance Imaging

178

158

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The noninvasive assessment of lung function using imaging is increasingly of interest for the study of lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma. Hyperpolarized gas MRI (HP MRI) has demonstrated the ability to detect changes in ventilation, perfusion, and lung microstructure that appear to be associated with both normal lung development and disease progression. The physical characteristics of HP gases and their application to MRI are presented with an emphasis on current applications. Clinical investigations using HP MRI to study asthma, COPD, cystic fibrosis, pediatric chronic lung disease, and lung transplant are reviewed. Recent advances in polarization, pulse sequence development for imaging with Xe-129, and prototype low magnetic field systems dedicated to lung imaging are highlighted as areas of future development for this rapidly evolving technology.

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“…Xe is less suited to this self pressure broadening technique due to its much higher spin destruction rate at high pressure and therefore optical pumping is typically performed in a gas mixture with a few percent Xe and nitrogen with the bulk being 4 He, which is added to pressure broaden the absorption line. This mode of operation has been used by a number of teams [12,13]. One of the main limitations of this approach is laser heating, where elevated nitrogen temperatures of several 100…”

Section: Hyperpolarisedmentioning

confidence: 99%

Enhancement of X129e polarization by off-resonant spin exchange optical pumping

Parnell

Deppe

Parra‐Robles

et al. 2010

Journal of Applied Physics

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A high power narrow line width (38W, 0.09nm FWHM) external cavity diode laser is investigated for rubidium spin exchange optical pumping of 129 Xe. This tunable photon source has a constant line width, independent of operating power or wavelength within a 1 nm tuning range. When using this laser, an increase in the 129 Xe nuclear polarisation is observed when optically pumping at a lower wavelength than the measured Rb electron D 1 absorption. The exact detuning from D 1 for the highest polarisation is dependent upon the gas density. Furthermore, at high power and/or high Rb density, a reduction of the polarisation occurs at the optimum wavelength as previously reported in SEOP studies of 3 He which is consistent with high absorption close to the cell front face. These results are encouraging for moderate high throughput polarisation of 129 Xe in the mid pressure range of (0.5-2.0 amg). * Electronic address: S.R.Parnell@Sheffield.ac.uk † Electronic address: J.M. Wild@Sheffield.ac.uk

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High capacity production of >65% spin polarized xenon-129 for NMR spectroscopy and imaging

Cited by 112 publications

References 23 publications

NMR detection using laser-polarized xenon as a dipolar sensor

NMR detection using laser-polarized xenon as a dipolar sensor

Functional lung imaging using hyperpolarized gas MRI

Enhancement of X129e polarization by off-resonant spin exchange optical pumping

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