High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

Spadaro, A.; Tortorella, Vincenza; Morace, Carmela; Fortiguerra, A.; Composto, Paola; Bonfiglio, Caterina; Alibrandi, Angela; Luigiano, Carmelo; de, G.; Ajello, A; Ferraù, O; Freni, M.

doi:10.3748/wjg.14.1549

Cited by 36 publications

(25 citation statements)

References 13 publications

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“…Repeated D-dimer measurement after ascites resolution showed significant decrease in mean circulating D-dimer levels, but they were still higher than in patients who entered the study without ascites. This is in contrast to the findings of Spadaro et al (12) who reported of mean plasma D-dimer levels after ascites resolution returning to normal levels in half of the patients. We noted with much interest that in patients who were treated with conventional diuretic therapy to obtain ascites resolution D-dimer showed a significant decrease to mean levels not differing from those without ascites suggesting that the mode of ascites resolution has an impact on fibrinolytic activity.…”

Section: Discussioncontrasting

confidence: 99%

Association Between High D-dimer Plasma Levels and Ascites in Patients with Liver Cirrhosis

Saray

Mesihović²,

Gornjakovic³

et al. 2012

Med Arh

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Section: Discussioncontrasting

confidence: 99%

Association Between High D-dimer Plasma Levels and Ascites in Patients with Liver Cirrhosis

Saray

Mesihović²,

Gornjakovic³

et al. 2012

Med Arh

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“…This is consistent with data from cirrhotic, HIV-uninfected individuals, in whom D-dimer levels were found to increase as hepatic impairment progresses [32]. However, similarly to other fibrosis markers, HA is not liver specific and may reflect other pathologies.…”

Section: Discussionsupporting

confidence: 89%

Factors Associated with D-Dimer Levels in HIV-Infected Individuals

et al. 2014

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BackgroundHigher plasma D-dimer levels are strong predictors of mortality in HIV+ individuals. The factors associated with D-dimer levels during HIV infection, however, remain poorly understood.MethodsIn this cross-sectional study, participants in three randomized controlled trials with measured D-dimer levels were included (N = 9,848). Factors associated with D-dimer were identified by linear regression. Covariates investigated were: age, gender, race, body mass index, nadir and baseline CD4+ count, plasma HIV RNA levels, markers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6]), antiretroviral therapy (ART) use, ART regimens, co-morbidities (hepatitis B/C, diabetes mellitus, prior cardiovascular disease), smoking, renal function (estimated glomerular filtration rate [eGFR] and cystatin C) and cholesterol.ResultsWomen from all age groups had higher D-dimer levels than men, though a steeper increase of D-dimer with age occurred in men. Hepatitis B/C co-infection was the only co-morbidity associated with higher D-dimer levels. In this subgroup, the degree of hepatic fibrosis, as demonstrated by higher hyaluronic acid levels, but not viral load of hepatitis viruses, was positively correlated with D-dimer. Other factors independently associated with higher D-dimer levels were black race, higher plasma HIV RNA levels, being off ART at baseline, and increased levels of CRP, IL-6 and cystatin C. In contrast, higher baseline CD4+ counts and higher high-density lipoprotein cholesterol were negatively correlated with D-dimer levels.ConclusionsD-dimer levels increase with age in HIV+ men, but are already elevated in women at an early age due to reasons other than a higher burden of concomitant diseases. In hepatitis B/C co-infected individuals, hepatic fibrosis, but not hepatitis viral load, was associated with higher D-dimer levels.

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“…It is a sensitive marker of coagulation and fibrinolysis. Hyperfibrinolysis in cirrhotic patients might represent a state of low grade disseminated intravascular coagulation [24,25].…”

Section: Resultsmentioning

confidence: 99%

Value of Protein C and D-Dimer in Predicting Non Hepatocellular Carcinoma Portal Vein Thrombosis in Patients with Liver Cirrhosis

El-Nemr

Galal

Khalifa

2016

Afro-Egyptian Journal of Infectious and Endemic Diseases

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High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

Cited by 36 publications

References 13 publications

Association Between High D-dimer Plasma Levels and Ascites in Patients with Liver Cirrhosis

Association Between High D-dimer Plasma Levels and Ascites in Patients with Liver Cirrhosis

Factors Associated with D-Dimer Levels in HIV-Infected Individuals

Value of Protein C and D-Dimer in Predicting Non Hepatocellular Carcinoma Portal Vein Thrombosis in Patients with Liver Cirrhosis

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