High Concentration of (1→3)-β-D-Glucan in BAL Fluid in Patients With Acute Eosinophilic Pneumonia

Kawayama, Tomotaka; Fujiki, Rei; Honda, Junichi; Rikimaru, Toru; Aizawa, Hisamichi

doi:10.1378/chest.123.4.1302

Cited by 20 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding that β‐glucan levels were higher in patients with sarcoidosis is similar to the findings in previous studies on acute eosinophilic pneumonia and hypersensitivity pneumonitis . Our results suggest that the degree of β‐glucan in the lungs reflects the fungal exposure at home.…”

Section: Discussionsupporting

confidence: 91%

Inflammatory markers and pulmonary granuloma infiltration in sarcoidosis

et al. 2013

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Inflammatory markers and pulmonary granuloma infiltration in sarcoidosis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Additionally, β-glucan was found to enhance NF-ĸB activation of rat alveolar epithelial cells to produce macrophage inflammatory protein-2 and TNF-α mRNA. However, the quantification of β-glucan in human airways has not yet been investigated except in acute eosinophilic pneumonia [6]. Furthermore, to the best of our knowledge, there have been no previous reports on how much exposure to β-glucan is necessary to activate human respiratory epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…(1→3)β- D -Glucan (β-glucan), a cell wall constituent of fungi, can induce activate immune responses [5], and its significance in the pathogenesis of respiratory diseases has been shown in acute eosinophilic pneumonia and Pneumocystis carinii pneumonia as well as in fungus infections [6,7,8]. Since straw for feed is stored throughout the year, farmers may be exposed to β-glucan in moldy hay.…”

Section: Introductionmentioning

confidence: 99%

Elevated Levels of β-<i>D</i>-Glucan in Bronchoalveolar Lavage Fluid in Patients with Farmer’s Lung in Miyazaki, Japan

Ashitani

Kyoraku²,

Yanagi³

et al. 2007

Respiration

View full text Add to dashboard Cite

Background: Farmers may be often exposed to β-D-glucan in moldy hay, since straw for feed can be stored throughout the year. Objectives: The aim of the present study was to clarify whether levels of β-D-glucan, which modifies immune responses, are high in the respiratory tract in farmer’s lung and whether β-D-glucan participates in the pathogenesis of this condition. Methods: We measured β-D-glucan levels in the bronchoalveolar lavage fluid (BALF) of 10 patients with farmer’s lung, 4 with summer-type hypersensitivity pneumonitis (HP) and 10 healthy volunteers. Interleukin (IL)-8 and tumor necrosis factor (TNF)-α levels in BALF were measured by enzyme-linked immunosorbent assay (ELISA). We investigated the effects of β-D-glucan on nuclear factor (NF)-ĸB activation and on the release of IL-8 and TNF-α from small airway epithelial cells (SAECs) in vitro. Results: β-D-Glucan levels in the BALF of farmer’s lung patients were increased compared to those in patients with summer-type HP and in healthy volunteers. Additionally, IL-8 levels in BALF were higher in farmer’s lung than in summer-type HP, and TNF-α levels were equal in the two patient groups but raised compared to those in healthy volunteers. High, but not low, concentrations of β-D-glucan were found to induce NF-ĸB activation in SAECs. IL-8 levels in the supernatant obtained from SAEC cultures were increased following the addition of β-D-glucan in vitro. Conclusion: BALF from farmer’s lung patients showed high β-D-glucan levels, which may enhance the expression and release of cytokines through NF-ĸB activation in respiratory epithelial cells.

show abstract

“…Serum IgG levels, particularly those of the IgG2 and IgG4 subclasses, are lower in patients with AEP than in healthy subjects (110). Though no specific fungal etiologies have been found to underpin idiopathic AEP, high concentrations of (1 ¡ 3)-␤-D-glucan have been observed in the BAL fluid of AEP patients (77).…”

Section: Aepmentioning

confidence: 99%

Eosinophilic Pneumonias

2012

View full text Add to dashboard Cite

SUMMARY This review starts with discussions of several infectious causes of eosinophilic pneumonia, which are almost exclusively parasitic in nature. Pulmonary infections due specifically to Ascaris , hookworms, Strongyloides , Paragonimus , filariasis, and Toxocara are considered in detail. The discussion then moves to noninfectious causes of eosinophilic pulmonary infiltration, including allergic sensitization to Aspergillus , acute and chronic eosinophilic pneumonias, Churg-Strauss syndrome, hypereosinophilic syndromes, and pulmonary eosinophilia due to exposure to specific medications or toxins.

show abstract

High Concentration of (1→3)-β-D-Glucan in BAL Fluid in Patients With Acute Eosinophilic Pneumonia

Cited by 20 publications

References 22 publications

Inflammatory markers and pulmonary granuloma infiltration in sarcoidosis

Inflammatory markers and pulmonary granuloma infiltration in sarcoidosis

Elevated Levels of β-<i>D</i>-Glucan in Bronchoalveolar Lavage Fluid in Patients with Farmer’s Lung in Miyazaki, Japan

Eosinophilic Pneumonias

Contact Info

Product

Resources

About