High concentrations of landiolol, a β1-adrenoceptor antagonist, stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway

Abstract

These results suggest that high concentrations of landiolol could cause airway smooth muscle contraction through the Rho-kinase pathway, but not through the PI response coupled with muscarinic M(3) receptors, 5-HT receptors or the activation of L-type Ca(2+) channels.

Landiolol: pharmacology and its use for rate control in atrial fibrillation in an emergency setting

“… 5 The weaker negative inotropic effect was confirmed using isolated perfused guinea pig hearts. 6 In addition, the same team using isolated myocyte and patch-clamp techniques showed that esmolol inhibited both the inward rectifier K+ current and the L-type Ca2+ current, and increased the outward current dose-dependently. In contrast, landiolol had minimal cardiac myocyte effects.…”