High Consumption of Fish Tends to Be Inversely Associated With the Risk of Colorectal Cancer

Zhang, Changjiang; Chen, Pengfei

doi:10.1016/j.cgh.2019.07.059

Cited by 2 publications

(3 citation statements)

References 19 publications

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“…Finally, this review on white meat and eggs was based on a small number of studies, and the evidence was low; thus, the findings for these food groups should be interpreted with caution. The current findings related to dairy products and fish confirm those from previous meta-analyses [7,12,67,68]. The main new findings of the present review are those related to specific subtypes of fish (in particular, canned fish), white meat, and eggs.…”

Section: Discussionsupporting

confidence: 89%

“…These findings agree with those previously reported in two recent meta-analyses [67,68]. In the meta-analysis of Caini et al [67], it is suggested that the aforementioned association may be attributable to several biological mechanisms, such as those related to ω-3 polyunsaturated fatty acids (PUFAs) that: (i) affect eicosanoids metabolism [69], (ii) are incorporated into membrane phospholipids, and (iii) that do not enhance the luminal concentration of secondary bile acids and the lower colon and liver activity of ornithine decarboxylase and tyrosine-specific protein kinase, all these mechanisms involved in colon carcinogenesis [70].…”

Section: Study Characteristics About Fish White Meat and Eggssupporting

confidence: 94%

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Role of Dairy Foods, Fish, White Meat, and Eggs in the Prevention of Colorectal Cancer: A Systematic Review of Observational Studies in 2018–2022

2022

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There is limited evidence to support the relationship between the consumption of animal-source foods other than red meat and processed meat and colorectal cancer (CRC) risk. We aimed to examine the recent available evidence from observational studies about the association between these food groups’ intake and CRC risk. For this systematic review, we searched the PubMed database for the last five years. A total of fourteen cohort studies and seven case–control studies comprising a total of >60,000 cases were included. The studies showed a consistent significant decrease in CRC risk, overall and by subsites, associated with a high consumption of total dairy products. Less strong effects associated with the consumption of any subtype of dairy product were observed. Fish consumption, overall and by subtypes (oily or non-oily and fresh or canned), showed a mild inverse association with CRC risk. The association between white meat and egg intake and CRC risk was low and based on a small number of studies; thus, these findings should be interpreted with caution. In conclusion, a high consumption of total dairy products was associated with a lower CRC risk. However, evidence for fish, white meat, and eggs and the CRC risk were not as strong.

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Section: Discussionsupporting

confidence: 89%

Section: Study Characteristics About Fish White Meat and Eggssupporting

confidence: 94%

Role of Dairy Foods, Fish, White Meat, and Eggs in the Prevention of Colorectal Cancer: A Systematic Review of Observational Studies in 2018–2022

2022

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“…For instance, it has been shown that the consumption of n-3 PUFAs (as pure compounds or as a part of FO) inversely correlates with the risk of various cancerous tumors, including the most common prostate, breast, and colorectal cancer ( Terry et al, 2001 ; Pauwels and Kairemo, 2008 ; Wu et al, 2012 ; Fabian et al, 2015 ; Lin et al, 2019 ; Aglago et al, 2020 ). In addition, the combined use of EPA and DHA with various antiblastoma agents enhances their effect in experiments and clinical conditions in several solid tumors and hemablastoses ( Cockbain et al, 2012 ; Jing et al, 2013 ; Merendino et al, 2013 ; Lee et al, 2017 ; Zhang and Chen, 2020 ; Chen et al, 2021 ; Newell et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

In Vivo Antitumoral Effects of Linseed Oil and Its Combination With Doxorubicin

et al. 2022

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Linseed oil (LO) is known for its exceptional nutritional value due to the high content of alpha-linolenic acid (ALA), an essential omega-3 polyunsaturated fatty acid; its anticarcinogenic effect has been established in several experimental and epidemiological studies. As an adjuvant of chemotherapeutic agents, LO and other ALA-rich vegetable oils have been studied in only a handful of studies at the experimental level. However, the efficacy of antitumoral therapy using doxorubicin (Dox) in combination with ALA and ALA-rich substrates has not yet been investigated. In this work, the antitumor activity of LO in a wide dose range was studied with monotherapy and combined with Dox in animal models with Pliss lymphosarcoma (PLS) and Lewis lung adenocarcinoma (LLC). It was founded the daily oral administration of LO (1, 3, and 10 ml per 1 kg) to rats (PLS) and 6 ml/kg to mice (LLC) for 11–12 days from 7 days after subcutaneous transplantation of tumors has a stable statistically significant effect on the dynamics of tumor growth, reducing the intensity of tumor growth and increasing the frequency of complete tumor regressions (CR) compared with the control. LO showed high antimetastatic activity in the LLC model. Furthermore, LO at a dose of 3 ml/kg potentiates the antitumor effect of Dox in the PLS model, reducing the volume of tumors at the end of treatment by 2.0 times (p = 0.013), the value of the tumor growth index by 1.6 times (p < 0.03) and increasing the frequency of CR 60 days after the start of therapy by 3.5 times (p = 0.019) compared with the use of Dox alone. The combination of Dox and LO or fish oil allows growing efficiency therapy of LLC in comparison with Dox alone, increasing the frequency of CR to 73.68% and 94.4%, respectively, and reducing the frequency of metastasis to zero.

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High Consumption of Fish Tends to Be Inversely Associated With the Risk of Colorectal Cancer

Cited by 2 publications

References 19 publications

Role of Dairy Foods, Fish, White Meat, and Eggs in the Prevention of Colorectal Cancer: A Systematic Review of Observational Studies in 2018–2022

Role of Dairy Foods, Fish, White Meat, and Eggs in the Prevention of Colorectal Cancer: A Systematic Review of Observational Studies in 2018–2022

In Vivo Antitumoral Effects of Linseed Oil and Its Combination With Doxorubicin

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