2007
DOI: 10.4161/cbt.6.4.3817
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High copy amplification of the aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers

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Cited by 75 publications
(67 citation statements)
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References 39 publications
(58 reference statements)
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“…Values higher than 2.0 were considered positive for gene amplification. Genomic DNA isolated from DLD1 and Caco-2 cell lines, respectively served as negative and positive control for AURKA gene amplification 64 .…”
Section: Methodsmentioning
confidence: 99%
“…Values higher than 2.0 were considered positive for gene amplification. Genomic DNA isolated from DLD1 and Caco-2 cell lines, respectively served as negative and positive control for AURKA gene amplification 64 .…”
Section: Methodsmentioning
confidence: 99%
“…Still, the clinically relevant aspect of aurora A 'over'expression has so far been mostly defined by the presence of an elevated number of aurora A positive tumour cells. As aurora A expression also changes tightly within the cell cycle, 49,50 the previously observed aurora A gene amplification 40,41 and particularly the aurora A overexpression in colorectal cancers 40,[42][43][44] may have been influenced by the fraction of proliferating tumour cells.…”
mentioning
confidence: 91%
“…45 In addition, our array-based comparative genomic hybridisation analysis suggested that chromosomal instable carcinomas exhibit preferential amplification of the aurora A gene locus at 20q13. 46 Similarly, Nishida et al 41 found that microsatellite instable colorectal cancers rarely have aurora A gene amplification, as measured by PCR. By mRNA expression profiling of microdissected invasive cancer cells from formalinfixed and paraffin-embedded colorectal cancers, we recently also detected aurora A as one prominently expressed gene in chromosomal instable tumours.…”
mentioning
confidence: 97%
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“…11 Furthermore this increase of centrosome production has been linked with the generation of a chromosomal instability (CIN) phenotype. 12,13 AURKB is found on chromosome 17p13, an area not typically amplified by tumors. 3 Beside the lack of amplification on gene level, several studies revealed an overexpression of mRNA and protein levels in several malignancies, associated with lymph node invasion, proliferation and metastasis.…”
Section: Introductionmentioning
confidence: 99%