High correlation between mechanical properties and bone mineral parameters in embalmed femurs after long-term storage

Wright, Bryan; Ragan, Lydia; Niratisairak, Sanyalak; Høiseth, Arne; Strømsøe, Knut; Steen, Harald; Brattgjerd, Jan Egil

doi:10.1016/j.clinbiomech.2018.09.013

Cited by 9 publications

(15 citation statements)

References 23 publications

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“…As we expected, bone mass can also reflect biomechanical strength. There is a high correlation between the bone mineral parameters and the biomechanical properties [ 29 ]. CMS increased the bone mass of the C6 ventral vertebra at 4 weeks, which can infer that biomechanical properties of the ventral vertebra were also increased.…”

Section: Discussionmentioning

confidence: 99%

Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats

Liu

Zhou

Liu

et al. 2020

Journal of Orthopaedic Translation

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Background The vertebral endplate (VEP) was damaged after spinal instability induced by cervical muscle section (CMS). Whether CMS induces bone formation and mechanical loading change in the vertebra is still obscure. This study was aimed to explore mechanical loading change and endplate damage after CMS. Methods Forty-eight rats were randomly divided into the CMS group and the sham group. The C6/7 segments were harvested at 4, 8, and 12 weeks after surgery. The microarchitectures of the C6 vertebra and the vertebral endplate lesions and intervertebral disc height of C6/7 were measured by micro–computed tomography. Micro–finite element analysis was used to evaluate biomechanical properties of the C6 vertebra. Bone remodelling of the C6 vertebra and the endplate sclerosis and intervertebral disc degeneration of C6/7 were evaluated by histological and immunohistochemical analyses. Results CMS significantly induced bone formation of the C6 ventral vertebra and increased the biomechanical properties of mainly the ventral side at 4 weeks, which was gradually rebalanced throughout the rest of the study. CMS also significantly increased protein expression of transforming growth factor-β1 (TGF-β1) and phosphorylated small mothers against decapentaplegic (pSmad)2/3 at 4 weeks. Moreover, tartrate-resistant acid phosphatase staining showed that osteoclast-positive cells were slightly in number decreased at 4 weeks, but were obviously increased at 8 weeks. The VEP of the ventral side was abraded earlier followed by calcification in situ later after CMS, consistent with the biomechanical enhancements observed. The degree of endplate degeneration was aggravated with time. Finally, CMS decreased intervertebral disc height and increased disc degeneration scores with time. Conclusions Spinal instability induced by CMS increases bone mass and biomechanical loading of the ventral side of vertebra in the early stage, which might initiate VEP damage and cause intervertebral disc degeneration. The translational potential of this article Our study indicates that vertebral trabecular changes may involve in intervertebral disc degeneration induced by spinal instability. This may help to elucidate the mechanisms by which disc degeneration occur.

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Section: Discussionmentioning

confidence: 99%

Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats

Liu

Zhou

Liu

et al. 2020

Journal of Orthopaedic Translation

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“…With synthetic bone, no randomisation has been considered necessary Hunt et al, 2012;. A paired human study is ideal with a pairwise homogenic anatomical, structural, mineral and biomechanical parameters (Young et al, 2013;Wright et al, 2018). In multiple comparisons, the low inter-specimen variability in replicas is advantageous .…”

Section: Methodsmentioning

confidence: 99%

“…In upright position, the shaft is 5-7° adducted (Dahl and Rinvik, 2010). While the femoral geometry varies greatly both with age and gender (Toogood et al, 2009), the intrapair correlation is high down to its mineral content (Young et al, 2013;Wright et al, 2018). The femur forms a stable ball and socket joint with acetabulum, which is faced anteriorly (20°) and laterally (45°).…”

Section: Anatomy Hip Geometrymentioning

confidence: 99%

“…In material strength, the water´s shock absorbing function contributes to its viscoelasticity (Turner and Burr, 1993), the organic part further explains flexibility, while the inorganic part makes bone solid (Nordin and Frankel, 2012). The local bone mineral content is an important predictor of mechanical strength (Wright et al, 2018). A reduced bone mineral quality reduces implant anchorage and femoral head fixation (Leicher et al, 1982;Goldhahn et al, 2008).…”

Section: Bonementioning

confidence: 99%

“…It is the method of choice to determine the effects of mechanical loading on bone, but may be limited by factors such as costs, operator training, physical dimensions, image resolution and radiation dose (MacIntyre et al, 2012). Assessment of bone mineral by QCT permits a more detailed understanding of its role to predict the local fixation strength (Alho et al, 1995) and has been used to validate the use of embalmed femurs ex vivo (Wright et al, 2018).…”

Section: Radiological Examinationsmentioning

confidence: 99%

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Intermediate Dynamic Compression and Decreased Posterior Tilt With Interlocked Pins in Femoral Neck Fixation in Synthetic Bone

Brattgjerd

Niratisairak

Steen

et al. 2021

Journal of Biomechanical Engineering

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Fixation failure with resulting nonunion is the key complication after femoral neck fixation. It can be avoided by permitting dynamic compression and reducing rotation and posterior tilt of the femoral head. To achieve this, a novel implant that features an interlocking plate with 3 hook-pins (The Hansson Pinloc? System) was developed from the original 2 hook-pins. Only an enhanced torsional fixation by the implant modification is reported. The purpose was to compare the biomechanical compressive and bending stability of the original and modified implant in femoral neck fixation. To analyse the contribution of both modified components, 3 individual pins were included, although not in regular use. Forty-eight synthetic femurs with midcervical wedge osteotomies were fixated by 2 pins or identical triangular pin patterns with or without the plate. Eight specimens of each group were loaded cyclically in compression with an inferior wedge to simulate stance and anteroposterior bending with a posterior wedge to imitate sitting down. The clinically relevant stability measurements were stiffness and deformation. Fissure formation defined failure. The novel implant improved bending stability by 30% increased stiffness, 44% reduced deformation and less frequent posterior neck fissure formation (p < 0.001). Increased compressive stability were only evident with 25% reduced deformation and less frequent inferior neck fissures (p < 0.001). These impacts were mainly mediated by the 3rd pin, while the plate prevented a lateral fissure in compression (p < 0.001). The clinical stability was improved by dynamic compression and decreased posterior tilt by implant modification.

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Characterization of the mechanical properties of human parietal bones preserved in modified larssen solution, formalin and as fresh frozen

et al. 2021

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High correlation between mechanical properties and bone mineral parameters in embalmed femurs after long-term storage

Cited by 9 publications

References 23 publications

Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats

Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats

Intermediate Dynamic Compression and Decreased Posterior Tilt With Interlocked Pins in Femoral Neck Fixation in Synthetic Bone

Characterization of the mechanical properties of human parietal bones preserved in modified larssen solution, formalin and as fresh frozen

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