High-Current Light-Ion Cyclotron for Applications in Nuclear Security and Radioisotope Production

Johnstone, C.; Kutsaev, Sergey; Lanza, R.; Boucher, S.; Johnson, Richard R.

doi:10.1109/tns.2021.3072978

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…An advanced, small-footprint, heavy ion injector iso-cyclotron has been developed for the injector. This novel normal-conducting, separated-sector injector has an optimized strong-focusing field gradient designed to efficiently accelerate light ions with a chargeto-mass near 1 2 (namely, protons in the form of H 2 + , D + , He 2+ , Li 3+ , B 5+ , C 6+ , N 7+ , O 8+ , Ne 10+ , S 16+ , and Ca 20+ ) scalable up to 70-100 MeV/u [51,52]. Dual, high-gradient, 0.2 MV cavities with a tuning range of ±1% in frequency can accelerate any ion species with this charge to a mass ratio on the 8th harmonic (~45 MHz) with a large turn-to-turn, almost centimeter-level separation-an enabling compact and low-loss extraction technology that eliminates the charge-changing foils (used for injection in ion synchrotrons and extraction in H − cyclotrons).…”

Section: Source Lebt and Rfq And Injectormentioning

confidence: 99%

Transformative Technology for FLASH Radiation Therapy

et al. 2023

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The general concept of radiation therapy used in conventional cancer treatment is to increase the therapeutic index by creating a physical dose differential between tumors and normal tissues through precision dose targeting, image guidance, and radiation beams that deliver a radiation dose with high conformality, e.g., protons and ions. However, the treatment and cure are still limited by normal tissue radiation toxicity, with the corresponding side effects. A fundamentally different paradigm for increasing the therapeutic index of radiation therapy has emerged recently, supported by preclinical research, and based on the FLASH radiation effect. FLASH radiation therapy (FLASH-RT) is an ultra-high-dose-rate delivery of a therapeutic radiation dose within a fraction of a second. Experimental studies have shown that normal tissues seem to be universally spared at these high dose rates, whereas tumors are not. While dose delivery conditions to achieve a FLASH effect are not yet fully characterized, it is currently estimated that doses delivered in less than 200 ms produce normal-tissue-sparing effects, yet effectively kill tumor cells. Despite a great opportunity, there are many technical challenges for the accelerator community to create the required dose rates with novel compact accelerators to ensure the safe delivery of FLASH radiation beams.

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Section: Source Lebt and Rfq And Injectormentioning

confidence: 99%