Low carbon steels are frequently preferred in the automotive industry. The most preferred welding method in vehicle body manufacturing is resistance spot welding (RSW). In this study, RSW joints of DC04 and HRP6222 steels were carried out at two different electrode forces (2.1 kN, 2.4 kN) and three different welding currents (4 kA, 6 kA, 8 kA). The effects of different welding parameters on microstructure, tensile shear force, failure mode and microhardness were investigated. So, the focus was on optimizing the welding parameters. As a result, the RSW process caused the formation of three different regions in the microstructure (the base metal, the heat affected zone and the weld metal). It was observed that the tensile shear force increased as the welding current and electrode force increased. After the tensile shear tests, two different failure modes occurred (interface and pull-out type). Hardness values showed a linear relationship with tensile shear force results. In addition, a significant increase in hardness values was observed from the base metal to the weld metal in all welding parameters.