High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice

Wang, Qianqian; Shi, Jinyuan; Khan, Mir Azam; Zhuang, Jiachen; Zhang, Junhui; Wang, Jing; Zhang, Xi; Feng, Fengqin

doi:10.1016/j.jff.2021.104677

Cited by 33 publications

(25 citation statements)

References 45 publications

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“…In general, higher muscle glycogen accumulation capacity may have a direct role in improving exercise endurance and reducing physical exhaustion, as seen by the improved physical performance in mice of the STP-H group. Additionally, the benefits of STP intervention on the alleviation of muscle injury were studied, and it was discovered that STP greatly decreased LDH and CK levels, indicating that STP has the capability to protect muscle from injury during swimming, which is line with the observations of a recent study [ 25 ]. According to these biochemical parameters, the STP supplement outscored the WP treatment in terms of metabolite accumulation, muscle damage, and glycogen reserve in the muscles.…”

Section: Discussionsupporting

confidence: 79%

“…The main reason for this is that bioactive peptides have a significant impact on cell metabolism. Bioactive peptides have recently been shown to be effective in lowering KEAP1 and NRF2 expression [ 25 ]. The NRF2/KEAP1 axis functions as a ‘thiol-driven master switch’ for ‘system-wide oxidative stress responses’.…”

Section: Discussionmentioning

confidence: 99%

“…The animal experiment was designed as described in our previous study with some modifications [ 25 ]. Male ICR mice (weight 20 ± 2 g) were purchased from SLAC Laboratory Animal Co., Ltd.(Shanghai, China) and subsequently maintained at Animal Experimental Center of Zhejiang Chinese Medicine University.…”

Section: Methodsmentioning

confidence: 99%

“…After a week of adaptation, they were randomly divided into the following 5 groups (n = 18): (1) normal control group (distilled water only, control), (2) whey peptides group (0.5 mg g −1 BW, WP), (3) low-dose STP group (0.25 mg g −1 BW, STP-L), (4) medium-dose STP group (0.5 mg g −1 BW, STP-M), and (5) high-dose STP group (1.0 mg g −1 BW, STP-H). Each group was given the appropriate sample by daily gavage administration for 30 days [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

“…The body weight and organ index were record and analyzed according to previous study [ 25 ]. The mice were weighed weekly.…”

Section: Methodsmentioning

confidence: 99%

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Soft-Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice

Shi

Zhang

Wang

et al. 2022

Foods

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The potential of soft-shelled turtle peptides (STP) against fatigue was evaluated. Mice orally supplemented with STP significantly increased the swimming time until tiredness by 35.4–57.1%. Although not statistically significant, STP increased muscle and thymus mass. In addition, the serum lactate, ammonia, blood urea nitrogen content and creatine kinase activity in STP-fed mice were dramatically decreased when compared to the control group. Furthermore, STP supplementation increased the reserves of liver glycogen and muscle glycogen, thus improved the energy metabolism system of mice. STP treatment contributed to increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as a decrease in malondialdehyde (MDA), indicating an improvement in oxidative stress protection. The Western blot (WB) results indicated that the STP supplement effectively altered the expression of oxidative stress-related protein by modulating the NRF2/KEAP1 pathway. In summary, STP affected NRF2/KEAP1 levels in skeletal muscle, leading to antioxidant activity and a slower time to exhaustion during exercise.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The body weight and organ index were record and analyzed according to previous study [ 25 ]. The mice were weighed weekly.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Soft-Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice

Shi

Zhang

Wang

et al. 2022

Foods

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Recent advances in sea cucumber peptide: Production, bioactive properties, and prospects

Man

El‐Aty

Wang³

et al. 2022

Food Frontiers

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Sea cucumber is a precious and nutritious food with abundant protein and other bioactive compounds, among which sea cucumber peptide (SCP) exhibits many beneficial functions. Although research on the development of SCP is attracting more attention, the ability to translate these new findings into industrial practice and new products remains immature. This review summarizes the production and characterization of SCP and emphasizes recent advances in its bioactive properties, including antioxidative, angiotensin‐I converting enzyme‐inhibitory, immunomodulatory, anticancer, antifatigue, and neuroprotective effects. Meanwhile, the challenges and prospects of SCP development have been discussed in both scientific research and commercialization. SCP shows great potential in health promotion, yet several challenges need to be solved: the validation of health claims, clarification of its mechanisms, innovations to boost its bioavailability, and improvement of industrial production and sensory properties of end‐products. Hopefully, this information will provide a comprehensive perspective on developing SCP nutraceuticals and functional foods.

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A comprehensive review of specific activity and intrinsic connections of food‐derived bioactive peptides for human health

Zhao,

Su,

Zhang

et al. 2024

Food Frontiers

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Food‐derived peptides have garnered significant attention in research due to their multifaceted functionalities, abundant availability, efficient utilization of agricultural by‐products, and environmentally sustainable preparation methods. These peptides play a crucial role in human health, yet their precise mechanisms of action remain largely unexplored, posing challenges in their screening, preparation, and effective application utilizing protein‐based raw materials. This review offers an extensive examination of 19 types of bioactive peptides derived from food. The sources of food‐derived bioactive peptides are well concluded and the classifications are made according to their potential health benefit based on five primary systems: general bodily functions, the nervous system, the cardiovascular system, the metabolic system, and the immune system. This review specifically highlights the multifaceted impacts of tasty peptides on human health, extending beyond their gustatory effects. Furthermore, it explores the interplay between various functions of bioactive peptides, noting a progression from basic to advanced functionalities. Antioxidant activity and the modulation of key enzymes are identified as fundamental actions that are interconnected with other functional properties. This implies that a single bioactive peptide could exhibit multiple beneficial effects. The key role of antioxidant capabilities is underscored based on their broad influence and straightforward assessment. This comprehensive analysis aims to deepen the systematic understanding of the diverse benefits offered by various food‐derived peptides.

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High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice

Cited by 33 publications

References 45 publications

Soft-Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice

Soft-Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice

Recent advances in sea cucumber peptide: Production, bioactive properties, and prospects

A comprehensive review of specific activity and intrinsic connections of food‐derived bioactive peptides for human health

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