High Density Lipoprotein Cholesterol Comes of Age

Cho, Hongkeun

doi:10.4070/kcj.2007.37.5.187

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…The sample was housed in a glass capillary tube in direct contact with the flowing helium vapor. A Bruker NMR spectrometer with a home-built probe and solenoidal coil [32] were used for NMR detection. Microwave irradiation was provided through a 90 mW Gunn diode source (Millitech), and the µWs were coupled from room temperature to the sample via a mm waveguide and horn antenna.…”

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confidence: 99%

Radical-free dynamic nuclear polarization using electronic defects in silicon

et al. 2013

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Direct dynamic nuclear polarization of 1 H nuclei in frozen water and water-ethanol mixtures is demonstrated using silicon nanoparticles as the polarizing agent. Electron spins at dangling-bond sites near the silicon surface are identified as the source of the nuclear hyperpolarization. This novel polarization method open new avenues for the fabrication of surface engineered nanostructures to create high nuclear-spin polarized solutions without introducing contaminating radicals, and for the study of molecules adsorbed onto surfaces.

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confidence: 99%

Radical-free dynamic nuclear polarization using electronic defects in silicon

et al. 2013

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“…This might give an indication to a good lipidemia control among Chinese as HDL is considered a cardio protective lipoprotein and according to ADA and Malaysian-MOH guidelines, rising HDL level is the second strategy in the treatment of diabetes dyslipidemia. [34][35][36] Limitations of the study As a retrospective data was unavailable to identify the BMI influence on individual subject. The subjects were enrolled according to the completeness of medical profile, so this can cause a possible bias in term of selecting the subjects with incomplete medical follow-up/record.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combined Therapy in Dyslipidemia and Hyperglicemia of Diabetes Mellitus Type II

Sulaiman

Zaki

Gillani

2010

Clinical Medicine Insights: Therapeutics

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Today the world is facing a high prevalence of dyslipidemia among type II diabetes, and in matter of fact clinical practices against hyperglycemic and hyperlipidemia were quiet intrusive. Our aim was to determine the therapeutic compliance against the clinical practices of dyslipidemia with type II diabetes in a multiracial society. A three year retrospective cohort study was planned to achieve the above mentioned objectives of the study. Study was carried out in outpatient department of General Hospital Penang over a period of ten months (Jan-Oct 2008). Study data collection duration was from Jan 2005-Dec 2007. All the concerned approvals were obtained from Clinical Research Committee (CRC). Data was analyzed by using SPSS 15 ®. A total of all only 501 diabetes type 2 patients with dyslipidemia were included in this study. The demographic data showed that 55.9% (n = 280) were female patients and 44.1% (n = 221) were male patients. According to racial distribution, Chinese constituted 41.7% of the study population, Malay 34.3% and Indians 24%. The mean age was 62.2 ± 9.2 years. About 56.1% of patients were more and equal than 60 years old range, while 43.9% were in the less or equal range of 59 years. Lifestyle and social habits data demonstrated 86.2% non-smokers, 74.1% with uncontrolled diet and 78.4% on bad exercise. Patients on combination therapy of metformin with other antidiabetic agent were 79%, while 21% were on monotherapy. The test analysis revealed that there was a significant difference between Malay and Chinese in FPG levels, in which the Malay had higher mean FPG than Chinese (mean difference Malay/Chinese 0.75991, P = 0.007). This study showed that both metformin and lovastatin were effective in reducing elevated glucose and lipid values. However, for glucose levels, the values were still above the normal limit used by the hospital. Among the multiracial study population, Chinese had the most controlled HDL levels and Malay had the highest uncontrolled FPG levels. Recommendations were associated with more frequent follow-up and therapeutic monitoring for the patient's condition by the health practitioners to determine the appropriate compliance with therapy and to control diabetes and dyslipidemia as per needed with therapeutic goals.

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“…High-density lipoprotein (HDL) is the particle transporting cholesterol from peripheral tissues to liver and thus high-density lipoprotein-cholesterol (HDL-C) has been considered as a major negative risk factor for coronary heart disease. 1) In Framingham study, 12 years of follow-up showed a significant HDL-C effect on total and cardiovascular (CV) mortality. 2) Not only epidemiologic studies but also clinical trials such as the Veterans Affairs High-density lipoprotein Intervention Trial (VA-HIT) suggested the beneficial effect of raising HDL-C. 3) Not only the direct effect, the role of HDL-C as a modifying factor of statin effect has been also reported.…”

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confidence: 99%