High dosage of monosodium glutamate causes deficits of the motor coordination and the number of cerebellar Purkinje cells of rats

Prastiwi, Dani; Djunaidi, Achmad; Partadiredja, Ginus

doi:10.1177/0960327115572706

Cited by 21 publications

(17 citation statements)

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“…Between P4 and P10, animals were weighed and injected (subcutaneously, along the dorsal hindquarters) with MSG (4 mg/g) or saline (equivalent volume of 0.9% NaCl). This dosage of MSG has been shown previously to produce robust effects in the hippocampus and cerebellum [14,37]. Litters were weaned at P21 and the two cohorts (saline and MSG) were housed separately.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, repeated exposure to MSG, especially during the neonatal period, results in neuronal damage and cell death in a number of different brain regions [2,4,8,35,38]. Specifically, MSG exposure has been shown to result in fewer neurons in the spiral ganglion [5], severe degeneration of retinal ganglion cells [39,47], smaller brains and lower body weights [46], fewer cerebellar Purkinje cells, deficits in motor coordination [26,37] and fewer cortical neurons [6].…”

Section: Introductionmentioning

confidence: 99%

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Neonatal exposure to monosodium glutamate results in dysmorphology of orofacial lower motor neurons

et al. 2017

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Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and is stored and released by both neurons and astrocytes. Despite the important role of glutamate as a neurotransmitter, high levels of extracellular glutamate can result in excitotoxicity and apoptosis. Monosodium glutamate (MSG) is a naturally occurring sodium salt of glutamic acid that is used as a flavour enhancer in many processed foods. Neonatal exposure to MSG has been shown to result in neurodegeneration in several forebrain regions, characterised by neuronal loss and neuroendocrine abnormalities. However, the brainstem effects of neonatal MSG exposure have not been investigated. It is therefore hypothesized that MSG exposure during the early postnatal period would impact brainstem lower motor neurons involved in feeding behaviour. The effect of neonatal MSG exposure on brainstem lower motor neurons was investigated by exposing rat pups to either 4 mg/g MSG or saline from postnatal day (P) 4 through 10. On P28, brains were preserved by vascular perfusion with fixative, frozen sectioned and stained for Nïssl substance. The number, size and shape of brainstem motor neurons were compared between MSG and saline-exposed animals. MSG exposure had no impact on the total number of neurons in the nuclei examined. However, MSG exposure was associated with a significant increase in the number of round somata in both the trigeminal and facial nuclei. Furthermore, MSG exposure resulted in significantly smaller neurons in all motor nuclei examined. These results suggest that neonatal exposure to MSG impacts the development of brainstem lower motor neurons which may impact feeding and swallowing behaviours in young animals.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neonatal exposure to monosodium glutamate results in dysmorphology of orofacial lower motor neurons

et al. 2017

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“…Most of the respondents appeared to have little understanding of MSG and they were not frequent consumers of MSG. In addition, some of them did not know or had never heard of the term "monosodium glutamate (MSG)" [22]. It is commonly used by the Chinese but they do not use the term MSG and that may be the reason they were not aware of it, even though it is marketed in brands that they are familiar with [23].…”

Section: Resultsmentioning

confidence: 99%

Knowledge and Awareness of Monosodium Glutamate (Ajinomoto Salt) among Students

Sivaharini

Ganapathy

2020

JPRI

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The aim of the study is to evaluate the knowledge and awareness of monosodium glutamate(MSG) (Ajinomoto salt) among dental students. A cross-sectional study was conducted among 100 dental undergraduate students in Chennai. A pre-structured questionnaire was used for the survey. The responses were obtained and the data were extracted and analyzed statistically for understanding about MSG among students as well as their attitudes toward MSG. 56% of participants were aware and 25% were not and the remaining 19% of participants were heard somewhat. We concluded that the level of awareness about the health hazards caused by the consumption of products containing Monosodium Glutamate (MSG) as a food additive was not adequate.

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“…Values in each column followed by * are significantly different (P ≤ 0.05), and that followed by ** are highly significantly different (P ≤ 0.001) Fig. 4 Calibration curve of sodium glutamate obtained by the proposed HPLC method Prastiwi et al, 2015 found that the administration of MSG at a high dose of 3.5 mg/g body weight, but not at lower dosages, lead to significant decrease of motor coordination and the estimated total number of Purkinje cells of rats and significant correlation between motor coordination and the total number of Purkinje cells (Prastiwi et al, 2015).…”

Section: Discussionmentioning

confidence: 99%