High dose ascorbic acid in the management of thalassaemia leg ulcers—a pilot study

Afifi, Ahmed; Ellis, Laurence B.; Huntsman, R. G.; Said, Mina

doi:10.1111/j.1365-2133.1975.tb03085.x

Cited by 18 publications

(5 citation statements)

References 4 publications

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“…α-lipoic acid and NAC) potentially inhibit LDL oxidation, decrease oxidative stress, and attenuate hypertension, insulin resistance and oxidative stress. β-Thalassemia major patients who suffered from leg ulcers and were treated with ascorbic acid (3 g/day) for eight weeks showed a high rate of either complete or partial healing [109]. Improvement of ulcer healing in β-thalassemia major patients was observed when they were orally administered with pentoxifylline (1.2 g/day) which is xanthine derivative and functions as a competitive non-selective phosphodiesterase inhibitor [110].…”

Section: 7)mentioning

confidence: 99%

Antioxidants as Complementary Medication in Thalassemia

Srichairatanakool¹,

Fucharoen²

2014

Pharmacology and Nutritional Intervention in the Treatment of Disease

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Inhibitors of iron absorption (tea, Ca) Foods (phytate and oxalate) Antioxidative compounds (vitamin C, E, NAC) Antioxidative phytochemicals (flavonoids, curcuminoids) Oxidative stress Hemosiderosis Cardiomyopathy Liver inflammation and cirrhosis Thalassemias with iron overload (From Nature Genetics Review, 2004) Endocrinopathy Ineffective erythropoiesis Hormone supplement Hb F modifiers (hydroxyurea, hydroxycarbamide, decitabin and phenylbutyrate) Hb stimulating agents (erythropoietin, folic acid) Bone marrow transplantation Gene therapy HSC therapy (www.nctrallawblog.com) Blood transfusion (420 ml/unit  200 mg Fe) (http://saschina.org) Duodenal iron absorption (3-9 mg Fe/day in thalassemia intermedia) Bone deformity Hypercoagulability Vitamin D Osteoclast supplement Hydroxyurea Aspirin Coumadin Antioxidants as Complementary Medication in Thalassemia

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Section: 7)mentioning

confidence: 99%

Antioxidants as Complementary Medication in Thalassemia

Srichairatanakool¹,

Fucharoen²

2014

Pharmacology and Nutritional Intervention in the Treatment of Disease

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“…Afifi et al 34 evaluated the effect of administering 3 g of ascorbic acid daily for 16 weeks to eight patients with LLU due to major thalassemia in a crossover clinical trial. Patients were divided into two groups.…”

Section: Resultsmentioning

confidence: 99%

Nutrients with Antioxidant Properties and Their Effects on Lower-Limb Ulcers: A Systematic Review

Souza

Monteiro

Curioni

et al. 2022

The International Journal of Lower Extremity Wounds

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Chronic lower-limb ulcers (LLUs) are ulcers that fail to proceed through an orderly and timely process to produce anatomic and functional integrity. LLUs reduce the quality of life of affected individuals and are a public health problem. The treatment options include medications or surgery. Nutrition therapy is an important adjunct to improve the clinical picture and healing of LLUs. Considering that nutrients with antioxidant properties can improve the process of tissue healing, this systematic review aimed to evaluate the efficacy of antioxidant nutrient supplementation in the treatment of LLUs through randomized clinical trials. This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses and the Cochrane Handbook for Systematic Reviews of Interventions. The guiding question was—can antioxidant nutrients help in the treatment of chronic LLUs? In total, 1184 articles were found when searching for antioxidant nutrients associated with the most common causes of LLUs. Fourteen articles were included in this review after removing duplicates, studies with topical and/or venous use of antioxidants, and articles published in other languages, except English. Omega-3 fatty acids, magnesium, zinc, vitamins A, C, D, and resveratrol along with probiotics positively improved the ulcer healing. These effects were more significant when there was initially a deficiency of the respective supplemented nutrients. Therefore, correcting and maintaining an adequate nutritional status can improve ulcer healing and contribute to the clinical treatment of patients with LLUs.

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“…12,13 Next to collagen vitamin C has some wound healing effect, as majority of patients showed 10% -50% reduction in size of wound one month after the treatment with vitamin C. Insulin has minimal wound healing effects as 50% of patients showed no response and other 50% of patients s h o we d very minimal reduction in size of wound. In both vitamin C and insulin treated group, patients required longer healing duration.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on Wound Healing Using Placentrex, Collagen, Vitamin C and Insulin

Kamble¹,

Kamble²,

Abhishek³

2017

jemds

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BACKGROUNDThe present study was undertaken in Department of Surgery, Jawahar Lal Nehru Medical College and Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha. This study consists of 200 patients of various types of wounds. Equal number of patients of various type of wounds were randomly selected for the local treatment with Placentrex, collagen, vitamin C and insulin. Cleaning and debridement was done to all patients with infected wounds and systemic antibiotic was given according to sensitivity. Results were compared in terms of age, sex incidence, growth of culture organism, formation of healthy granulation tissue, percentage of reduction in size of wound, wound healing and duration of treatment in days/weeks.

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High dose ascorbic acid in the management of thalassaemia leg ulcers—a pilot study

Abstract: Eight patients with beta thalassaemia major suffering from leg ulcers, were treated over an 8-week period with 3 g ascorbic acid daily in a controlled double-blind crossover study. The ulcers of all the patients showed a high rate of either complete or partial healing.

Cited by 18 publications

References 4 publications

Antioxidants as Complementary Medication in Thalassemia

Antioxidants as Complementary Medication in Thalassemia

Nutrients with Antioxidant Properties and Their Effects on Lower-Limb Ulcers: A Systematic Review

A Comparative Study on Wound Healing Using Placentrex, Collagen, Vitamin C and Insulin

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