High-dose biotin in progressive multiple sclerosis : a prospective study of 86 patients in routine clinical practice

Abstract

Background: A recent controlled trial suggested that high-dose biotin supplementation reverses disability progression in patients with progressive multiple sclerosis. 4 Objective: To analyze the impact of high-dose biotin in routine clinical practice on disability 5 progression at 12 months. 6 Methods: Progressive multiple sclerosis patients who started high-dose biotin at Nantes or 7 Rennes Hospital between 3 June 2015 and 15 September 2017 were included in this 8 prospective study. Disability outcome measures, patient-reported outcome measures, relapses, 9 MRI data, and adverse events were collected at baseline, 6 months and 12 months. 10 Results: 178 patients were included. At baseline, patients were 52.0±9.4 years old, mean 11 Expanded Disability Status Scale (EDSS) score was 6.1±1.3, mean disease duration was 12