High-dose chemotherapy and autologous bone marrow or stem cell reconstitution for solid tumors

McGuire, William P.

doi:10.1016/s0147-0272(98)90005-8

Cited by 26 publications

(16 citation statements)

References 85 publications

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“…It is believed that a correlation exists between dose and response, and therefore, high-dose chemotherapy is commonly used in the treatment of certain cancers (Cripe, 1997;McGuire, 1998). However, in the case of anticancer prodrugs, dose escalation does not necessarily improve the anticancer effects.…”

Section: Discussionmentioning

confidence: 99%

Dose Optimization of a Doxorubicin Prodrug (HMR 1826) in Isolated Perfused Human Lungs: Low Tumor pH Promotes Prodrug Activation by β-Glucuronidase

Mürdter

Friedel²,

Backman³

et al. 2002

J Pharmacol Exp Ther

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Section: Discussionmentioning

confidence: 99%

Dose Optimization of a Doxorubicin Prodrug (HMR 1826) in Isolated Perfused Human Lungs: Low Tumor pH Promotes Prodrug Activation by β-Glucuronidase

Mürdter

Friedel²,

Backman³

et al. 2002

J Pharmacol Exp Ther

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“…Previous studies (Mauro, 1961;Cruess, 1982;Campion, 1984;Owen, 1988;Beresford, 1989;Ailhaud et al, 1992;Grounds et al, 1992;Rickard et al, 1994;Vierck et al, 1996;Caplan et al, 1997;Kadiyala et al, 1997;Prockop, 1997;Johnstone et al, 1998;Palis and Segel, 1998;McGuire, 1998;Ratajczak et al, 1998;Pittenger et al, 1999) established the existence of resident populations of lineage-committed progenitor stem cells and have proposed their involvement in maintenance and repair of body tissues. Studies from our lab and others (Grigoriadis et al, 1988;Young et al, 1992aYoung et al, , 1995Young et al, , 1998aYoung, 2000;Eisenberg and Markwald, 1997; have suggested the presence of both pluripotent stem cells and progenitor stem cells in prenatal animals.…”

Section: Stem Cells Residing In Tissuesmentioning

confidence: 99%

“…Tripotent reserve mesenchymal stem cells include the chondrogenic/ osteogenic/adipogenic stem cells of marrow (Pittenger et al, 1999). The multipotent hematopoietic stem cells of marrow (Palis and Segel, 1998;McGuire, 1998;Ratajczak et al, 1998) are an example of multipotent reserve mesenchymal stem cells. Multifunctional stem cell populations have been identified in prenatal species, i.e., the multipotent cardiogenic/hematopoietic/endotheliogenic cells of prenatal quail and mouse (Eisenberg and Markwald, 1997) and the pluripotent mesenchymal stem cells found in the connective tissues of prenatal avians, mice, and rats (Grigoriadis et al, 1988;Young et al, 1993Young et al, , 1998aRogers et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Preliminary studies involving postnatal rats, rabbits, and humans suggest that resident stem cells consist of both lineage-uncommitted pluripotent stem cells (Pate et al, 1993;Lucas et al, 1995Lucas et al, , 1996Young et al, 1999) as well as the established populations of lineage-committed progenitor stem cells (Mauro, 1961;Cruess, 1982;Campion, 1984;Owen, 1988;Beresford, 1989;Ailhaud et al, 1992;Grounds et al, 1992;Rickard et al, 1994;Vierck et al, 1996;Caplan et al, 1997;Prockop, 1997;Palis and Segel, 1998;McGuire, 1998;Ratajczak et al, 1998;Pittenger et al, 1999). The current clonogenic study was undertaken to determine whether clonal populations of pluripotent stem cells are present in the connective tissues of postnatal rats, and to examine their functional capabilities.…”

Section: Introductionmentioning

confidence: 99%

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Clonogenic analysis reveals reserve stem cells in postnatal mammals: I. Pluripotent mesenchymal stem cells

et al. 2001

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Clonal populations of lineage-uncommitted pluripotent mesenchymal stem cells have been identified in prenatal avians and rodents. These cells reside in the connective tissue matrices of many organs and tissues. They demonstrate extended capabilities for selfrenewal and the ability to differentiate into multiple separate tissues within the mesodermal germ line. This study was designed to determine whether such cells are present in the connective tissues of postnatal mammals. This report describes a cell clone derived by isolation from postnatal rat connective tissues, cryopreservation, extended propagation, and serial dilution clonogenic analysis. In the undifferentiated state, this clone demonstrates a high nuclear-to-cytoplasmic ratio and extended capacity for self-renewal. Subsequent morphological, histochemical, and immunochemical analysis after the induction of differentiation revealed phenotypic markers characteristic of multiple cell types of mesodermal origin, such as skeletal muscle, smooth muscle, fat cells, cartilage, and bone. These results indicate that this clone consists of pluripotent mesenchymal stem cells. This report demonstrates that clonal populations of reserve stem cells are present in mammals after birth. Potential roles for such cells in the maintenance, repair, and regeneration of mesodermal tissues are discussed.

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“…Tripotent progenitor cells include the chondrogenic-osteogenic-adipogenic stem cells of marrow (Pittenger et al, 1999;Young, 2000). Multipotent hematopoietic cells of marrow (McGuire, 1998;Palis and Segel, 1998;Ratajczak et al, 1998) are an example of multipotent progenitor cells. See Table 1 for additional examples of lineage-committed progenitor cells.…”

mentioning

confidence: 99%

Adult stem cells

2003

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Development of a multicellular organism is accomplished through a series of events that are preprogrammed in the genome. These events encompass cellular proliferation, lineage commitment, lineage progression, lineage expression, cellular inhibition, and regulated apoptosis. The sequential progression of cells through these events results in the formation of the differentiated cells, tissues, and organs that constitute an individual. Although most cells progress through this sequence during development, a few cells leave the developmental continuum to become reserve precursor cells. The reserve precursor cells are involved in the continual maintenance and repair of the tissues and organs throughout the life span of the individual. Until recently it was generally assumed that the precursor cells in postnatal individuals were limited to lineage-committed progenitor cells specific for various tissues. However, studies by Young, his colleagues, and others have demonstrated the presence of two categories of precursor cells that reside within the organs and tissues of postnatal animals. These two categories of precursor cells are lineage-committed (multipotent, tripotent, bipotent, and unipotent) progenitor cells and lineage-uncommitted pluripotent (epiblastic-like, ectodermal, mesodermal, and endodermal) stem cells. These reserve precursor cells provide for the continual maintenance and repair of the organism after birth. Anat Rec Part A 276A: 75-102, 2004.

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High-dose chemotherapy and autologous bone marrow or stem cell reconstitution for solid tumors

Cited by 26 publications

References 85 publications

Dose Optimization of a Doxorubicin Prodrug (HMR 1826) in Isolated Perfused Human Lungs: Low Tumor pH Promotes Prodrug Activation by β-Glucuronidase

Dose Optimization of a Doxorubicin Prodrug (HMR 1826) in Isolated Perfused Human Lungs: Low Tumor pH Promotes Prodrug Activation by β-Glucuronidase

Clonogenic analysis reveals reserve stem cells in postnatal mammals: I. Pluripotent mesenchymal stem cells

Adult stem cells

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