High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with primary metastatic Ewing sarcoma

Haveman, Lianne M.; Ewijk, Roelof van; Dalen, Elvira C. van; Breunis, Willemijn B.; Kremer, Leontien C. M.; Berg, Henk van den; Dirksen, Uta; Merks, Johannes H. M.

doi:10.1002/14651858.cd011405.pub2

Cited by 8 publications

(6 citation statements)

References 72 publications

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“…The addition of chemotherapeutics was done as previously described 54 . Briefly, or each cell line, 2 × 10 4 cells per 200 µL of full medium were transferred to 6 wells of a 24-well plate.…”

Section: Methodsmentioning

confidence: 99%

Effective combination of cold physical plasma and chemotherapy against Ewing sarcoma cells in vitro

Nitsch,

Qarqash,

Römer

et al. 2024

Sci Rep

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Ewing's sarcoma (ES) is the second most common bone tumor in children and adolescents and is highly malignant. Although the new chemotherapy has significantly improved the survival rate for ES from about 10 to 75%, the survival rate for metastatic tumors remains around 30%. This treatment is often associated with various side effects that contribute to the suffering of the patients. Cold physical plasma (CPP), whether used alone or in combination with current chemotherapy, is considered a promising adjunctive tool in cancer treatment. This study aims to investigate the synergistic effects of CPP in combination with cytostatic chemotherapeutic agents that are not part of current ES therapy. Two different ES cell lines, RD-ES and A673, were treated with the determined IC20 concentrations of the chemotherapeutic agents cisplatin and methotrexate (MTX) in combination with CPP. The effects on population doubling, cell viability, and apoptotic processes within these cell lines were assessed. This combination therapy has led to a reduction of population doubling and cell viability, as well as an increase in apoptotic activity in cells compared to CPP monotherapy. The results of this study provide evidence that combining CPP with non-common chemotherapy drugs such as MTX and CIS in the treatment of ES enhances the anticancer effects of these drugs. These findings open up new possibilities for the effective use of these drugs against ES.

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Section: Methodsmentioning

confidence: 99%

Effective combination of cold physical plasma and chemotherapy against Ewing sarcoma cells in vitro

Nitsch,

Qarqash,

Römer

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…For pediatric tumors, except for specific subgroups of lymphomas and germ-cell tumors, no other extracranial solid tumor indication of ASCT has been established as standard management for high-risk cases. ASCT strategies have failed to show benefit for Ewing sarcomas [ 18 ], Wilms tumors [ 19 ], non-rhabdomyosarcoma soft-tissue sarcomas [ 20 ], rhabdomyosarcomas [ 21 ], osteosarcomas [ 22 ], hepatoblastomas [ 23 ], and rhabdoid tumors [ 24 ].…”

Section: The Basic Principle Of Transplantation Expanded To Solid Tum...mentioning

confidence: 99%

Autologous Stem-Cell Transplantation for High-Risk Neuroblastoma: Historical and Critical Review

Mora

2022

Cancers

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Curing high-risk neuroblastoma (HR-NB) is a challenging endeavor, which involves the optimal application of several therapeutic modalities. Treatment intensity for cancer became highly appealing in the 1990s. Investigative trials assumed that tumor response correlated with the dosage or intensity of drug(s) administered, and that this response would translate into improved survival. It was postulated that, if myelotoxicity could be reversed by stem-cell rescue, cure might be possible by increasing the dose intensity of treatment. The principle supported autologous stem-cell transplant (ASCT) strategies. High-dose therapy transformed clinical practice, legislation, and public health policy, and it drove a two-decade period of entrepreneurial oncology. However, today, no ASCT strategies remain for any solid tumor indication in adults. As with most solid malignancies, higher dosing of cytotoxic agents has not resulted in a clear benefit in survival for HR-NB patients, whereas the long-term toxicity has been well defined. Fortunately, novel approaches such as anti-GD2 immunotherapy have demonstrated a significant survival benefit with a much less adverse impact on the patient’s wellbeing. On the basis of extensive experience, persisting with administering myeloablative chemotherapy as the standard to treat children with HR-NB is not consistent with the overall aim in pediatric oncology of curing with as little toxicity as possible.

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“…High-dose chemotherapy with autologous stem cell did not provide any beneficial effect (80,81). A recent Cochrane review concluded that when the location of primary ES/PNET metastasis, i.e., with metastatic disease at diagnosis, is other than the lungs, high-dose chemotherapy or autologous hematopoietic cell transplantation do not provide any advantage in event-free survival than those who receive conventional chemotherapy with whole lung irradiation (82). Palliative radiotherapy can provide symptom relief, especially pain, without a protracted treatment course for metastatic ES/PNET patients (83).…”

Section: Therapeutic Challenges Of Metastatic Es/pnetmentioning

confidence: 99%

Features of Metastatic Ewing Sarcoma

Zetouni

Sergi

2022

Metastasis

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Since its first description in 1921, Ewing sarcoma has been the subject of several morphologic and genetic investigations. Currently, the overall survival for localized Ewing sarcoma is 65-70%. However, in patients presenting with metastatic disease, the overall survival is poor, being in the range of 20-30%. There are several unknown features of Ewing sarcoma, such as its cell of origin, genetic background, chemotherapy resistance, and abnormal presentation sites, among others. A better understanding of the molecular basis of the development of Ewing sarcoma is needed to help improve survival, especially in metastatic/ resistance cases. In this chapter, we provide an overview of the features of metastatic Ewing sarcoma.

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High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with primary metastatic Ewing sarcoma

Abstract: High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with primary metastatic Ewing sarcoma

Cited by 8 publications

References 72 publications

Effective combination of cold physical plasma and chemotherapy against Ewing sarcoma cells in vitro

Effective combination of cold physical plasma and chemotherapy against Ewing sarcoma cells in vitro

Autologous Stem-Cell Transplantation for High-Risk Neuroblastoma: Historical and Critical Review

Features of Metastatic Ewing Sarcoma

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