High dose erythropoietin promotes functional recovery of rats following facial nerve crush

Zhang, Wei; Sun, Bin; Yu, Ziying; An, Jiping; Liu, Qilin; Ren, Taotao

doi:10.1016/j.jocn.2008.06.013

Cited by 17 publications

(11 citation statements)

References 29 publications

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“…In practice, partially injured peripheral nerves, which have a variable capacity to heal, are some of the most common injuries encountered. Large and predictable functional benefits of EPO treatment for peripheral nerve injuries have been described . This study expands on the current literature by evaluating whether the degree of injury has an effect on the response to EPO, particularly at early time‐points after injury.…”

Section: Discussionmentioning

confidence: 87%

“…Large and predictable functional benefits of EPO treatment for peripheral nerve injuries have been described. 16,18,19,28 This study expands on the current literature by evaluating whether the degree of injury has an effect on the response to EPO, particularly at early time-points Quantitative histomorphometry was performed in cross-sections taken from the moderate crush group at 7 days post-injury. Sections were taken from sites proximal to the crush (proximal), at the crush site (crush), and distal to the crush site (distal), then stained for myelin protein 0 (P 0 ) or neurofilament (NF).…”

Section: Discussionmentioning

confidence: 98%

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Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury

Geary

Zingman

et al. 2017

Muscle and Nerve

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Introduction Erythropoeitin (EPO) has been identified as a neuroregenerative agent. We hypothesize that it may accelerate recovery after crush injury and may vary with crush severity. Methods Mice were randomized to mild, moderate, or severe crush of the sciatic nerve and were treated with EPO or control after injury. Sciatic function index (SFI) was monitored over the first week. Microstructural changes were analyzed by immunofluorescence for neurofilament (NF) and myelin (P0), and electron microscopy was used to assess ultrastructural changes. Results In moderate crush injuries, EPO significantly improved SFI 7 days post-injury, an effect not observed in other severities. Increases in the ratio of P0 to NF were observed after EPO treatment in moderate crush injuries. Electron microscopy demonstrated endothelial cell hypertrophy in the EPO group. Conclusions EPO accelerates recovery in moderately crushed nerves, which may be through effects on myelination and vascularization. Injury severity may influence the efficacy of EPO.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury

Geary

Zingman

et al. 2017

Muscle and Nerve

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“…Although there are several other methods defined for conducting experimental facial nerve injury of rats, there is no standard method to induce crush injury. In this study, crush injury was induced by using a vascular clamp placed to the main trunk of the right facial nerve for 40 minutes after passing the stylomastoid foramen and before giving branches.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study

et al. 2015

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“…A promising therapeutic approach for peripheral nerve injury is to promote nerve regeneration, which includes the re-growth of injured axons as well as myelination, the restoration of synaptic connections and the recovery of physiological functions [ 3 – 5 ]. Erythropoietin (EPO) is originally identified as a renal cytokine that promotes hematopoiesis, but recent studies have shown that the administration of EPO enhanced axonal re-growth of peripheral nerve fibers and promoted functional recovery after peripheral nerve injury in rat models [ 6 , 7 ]. However, the mechanism of action of EPO in peripheral nerve repair remains incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

Experimental research Erythropoietin promotes peripheral nerve regeneration in rats by upregulating expression of insulin-like growth factor-1

Wang¹,

Li²,

Li³

et al. 2015

aoms

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IntroductionErythropoietin (EPO) has been shown to have beneficial effects on peripheral nerve damage, but its mechanism of action remains incompletely understood. In this study we hypothesized that EPO promotes peripheral nerve repair via neurotrophic factor upregulation.Material and methodsThirty adult male Wistar rats were employed to establish a sciatic nerve injury model. They were then randomly divided into two groups to be subjected to different treatment: 0.9% saline (group A) and 5000 U/kg EPO (group B). The walking behavior of rats was evaluated by footprint analysis, and the nerve regeneration was assessed by electron microscopy. The expression of insulin-like growth factor-1 (IGF-1) in the injured sciatic nerves was detected by immunohistochemical analysis.ResultsCompared to saline treatment, EPO treatment led to the growth of myelin sheath, the recovery of normal morphology of axons and Schwann cells, and higher density of myelinated nerve fibers. Erythropoietin treatment promoted the recovery of SFI in the injured sciatic nerves. In addition, EPO treatment led to increased IGF-1 expression in the injured sciatic nerves.ConclusionsErythropoietin may promote peripheral nerve repair in a rat model of sciatic nerve injury through the upregulation of IGF-1 expression. These findings reveal a novel mechanism underlying the neurotrophic effects of EPO.

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High dose erythropoietin promotes functional recovery of rats following facial nerve crush

Cited by 17 publications

References 29 publications

Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury

Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury

The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study

Experimental research Erythropoietin promotes peripheral nerve regeneration in rats by upregulating expression of insulin-like growth factor-1

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