2017
DOI: 10.21767/amj.2017.3153
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High dose, fast delivery magnesium sulphate in a 3-year-old acute severe asthmatic

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“…The order of broncho-dilating drugs should be IV magnesium sulphate 25–75 mg kg −1 over about 4 min [ 4 , 5 ]; IV salbutamol 15mcg.kg −1 over 10 min [ 6 ], or boluses of 5mcg.kg −1 over 1–2 min [ 7 ]. These doses will quickly achieve a serum level of salbutamol of 20–40 ng.L −1 at which full smooth muscle relaxation is thought to occur [ [8] , [9] , [10] , [11] ].…”
mentioning
confidence: 99%
“…The order of broncho-dilating drugs should be IV magnesium sulphate 25–75 mg kg −1 over about 4 min [ 4 , 5 ]; IV salbutamol 15mcg.kg −1 over 10 min [ 6 ], or boluses of 5mcg.kg −1 over 1–2 min [ 7 ]. These doses will quickly achieve a serum level of salbutamol of 20–40 ng.L −1 at which full smooth muscle relaxation is thought to occur [ [8] , [9] , [10] , [11] ].…”
mentioning
confidence: 99%