High-dose intravenous immunoglobulin treatment in cryptogenic West and Lennox-Gastaut syndrome; an add-on study

Engelen, B.G.M. van; Renier, W.O.; Weemaes, C.M.R.; Strengers, P. F. W.; Bernsen, P. J. H.; Notermans, S. L. H.

doi:10.1007/bf01954498

Cited by 55 publications

(31 citation statements)

References 27 publications

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“…For many years, VPA and benzodiazepines were frequently the mainstays of therapy (28). FBM, vigabatrin, and intravenous immunoglobulin have demonstrated efficacy in controlling seizures in LGS patients (29)(30)(31)(32)(33). Unfortunately, FBM use is limited by its reported association with aplastic anemia and hepatotoxicity, vigabatrin is still an investigational AED in the United States, and long-term intravenous immunoglobulin use in LGS children frequently involves technical problems with intravenous access, at times requiring placement of an indwelling catheter.…”

Section: Discussionmentioning

confidence: 99%

Lamotrigine Adjunctive Therapy in Childhood Epileptic Encephalopathy (the Lennox Gastaut Syndrome)

1997

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Summary: Purpose:We assessed efficacy and safety of adjunctive lamotrigine (LTG) therapy in patients with the Lennox-Gastaut syndrome (LGS).Methods: The study was a single-center, retrospective chart review of open-label adjunctive LTG therapy in patients with LGS. Initial LTG dose and titration was dependent on concomitant antiepileptic drugs (AEDs). Efficacy was based on the change in seizure frequency between the initiation of LTG therapy and December 1, 1995 (or LTG discontinuation). Seizure diaries were used to count patient seizures. A secondary evaluation of efficacy was a parental or guardian assessment of the patient's global status. The evaluation of safety involved chart review for treatment-emergent adverse events (AE).Results: Data from 16 LGS patients were analyzed. Fiftythree percent (8 of 15) had a >50% reduction in seizure frequency with LTG adjunctive therapy. Tonic, atonic, generalized tonic-clonic (GTCS), and atypical absence seizure frequency but not myoclonic seizure frequency decreased significantly during LTG therapy. Fifty-three percent of the patient's parents (8 of 15) reported that their child's quality of life (QOL) was much or very much improved during the study. The major treatment-emergent AE were infection (50%, 8 of 16) and sleep disturbance (19%, 3 of 16). A rash was noted in 13% (2 of 16) of the patients and resulted in LTG discontinuation in 1. No clinically significant changes were noted in neurologic examination or laboratory tests during the study.Conclusions: Our results indicate that LTG adjunctive therapy is effective and well tolerated in patients with LGS.

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Section: Discussionmentioning

confidence: 99%

Lamotrigine Adjunctive Therapy in Childhood Epileptic Encephalopathy (the Lennox Gastaut Syndrome)

1997

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“…The available data regarding a benefit for IGIV treatment comes mostly from uncontrolled open series or case reports. [194][195][196][197] However, there are 2 randomized placebo-controlled trials that have been performed for Lennox-Gastaut syndrome. One was a small (n 5 10) single-blind crossover study.…”

Section: Multiple Sclerosismentioning

confidence: 99%

Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

Orange

Hossny

Weiler³

et al. 2006

Journal of Allergy and Clinical Immunology

567

420

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“…Foi observada significativa redução das crises em crianças que usavam imunoglobulina endovenosa para tratamento de patologias respiratórias e passaram a usá-la como tratamento dos EI 13 . Neste estudo foi utilizada a dose de 400 mg/kg/dia, durante 5 dias e repetido a cada 2 semanas por 3 meses, com resultados esperançosos.…”

Section: Discussionunclassified

Espasmos infantis: experiência em treze casos

Fonseca

Oliveira²

2000

Arq. Neuro-Psiquiatr.

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RESUMO -Os espasmos infantis são crises típicas da primeira infância e constituem patologia grave, com prognóstico sombrio. Apresentamos a experiência no tratamento de 13 casos novos atendidos no Serviço de Neurologia Infantil do Centro Geral de Pediatria FHEMIG de Belo Horizonte no ano de 1997, bem como revisão da literatura sobre o assunto. Após propedêutica adequada encontramos 12 casos considerados sintomáticos e 1 criptogenético. Todos os casos foram tratados com ACTH durante 6 semanas, associado a drogas antiepilépticas orais de manutenção em mono ou politerapia. Os resultados com o ACTH foram excelentes num momento inicial, com resposta completa em todos os casos e efeitos colaterais que não contra-indicaram o tratamento. Porém houve índice de recorrência de 55%, sendo usada como droga de segunda linha a vigabatrina em 5 casos, com controle de 4 deles. Todos os casos apresentaram atraso do desenvolvimento neuropsicomotor.PALAVRAS-CHAVE: espasmos infantis, síndrome de West, ACTH. Infantile spasms: experience in thriteen casesABSTRACT -Infantile spasms are typical crisis found in the childhood being a serious pathology with an obscure prognosis. We present the experience of the Service of Neuropediatrics in the Pediatric General Center, Belo Horizonte -Brasil, during the year of 1997, with a review of the literature about. After appropriate propaedeutics, were found 12 cases considered symptomatics and 1 case cryptogenic. All these cases were treated with ACTH during 6 weeks associated with oral antiepileptic drugs in mono or polytherapy for maintenance. We had excellent results using ACTH at the beginning of the treatment, obtaining good results in all of the cases with some side effects that were not important enough to interrupt the treatment. However, there was a recurrence rate of 55% and vigabatrin was used as second option, controlling 4 of the 5 cases. All the cases showed retardation of the neuropsychomotor development.

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High-dose intravenous immunoglobulin treatment in cryptogenic West and Lennox-Gastaut syndrome; an add-on study

Cited by 55 publications

References 27 publications

Lamotrigine Adjunctive Therapy in Childhood Epileptic Encephalopathy (the Lennox Gastaut Syndrome)

Lamotrigine Adjunctive Therapy in Childhood Epileptic Encephalopathy (the Lennox Gastaut Syndrome)

Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

Espasmos infantis: experiência em treze casos

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