High-dose intravenous vitamin C treatment for COVID-19

Erol, Adnan

doi:10.31219/osf.io/p7ex8

Cited by 47 publications

(54 citation statements)

References 15 publications

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“…However, new knowledge regarding the pharmacokinetic properties of Vit-C, and recent preclinical studies, have revived interest in the utilization of high-dose Vit-C for cancer treatment [132][133][134][135][136][137][138][139][140][141][142][143][144][145]. Similar is the case of using IV Vit-C as antiviral, especially for the recent Covid19 [146][147][148][149][150]. It is believed that IV Vit-C has been particularly effective by inhibiting the production of cytokines storm due to Corvid19.…”

Section: Discussionmentioning

confidence: 99%

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

2020

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Section: Discussionmentioning

confidence: 99%

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

2020

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“…Vitamin C has also been evoked for use in cases of SARS-CoV-2 infection, since at high doses it could result in the immunosuppression of hyperactivation immune effector cells that cause lung injury in COVID-19 cases, while being a safe treatment option [56].…”

Section: Developing Drugsmentioning

confidence: 99%

Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options

2020

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Since December 2019, coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in devastating consequences worldwide and infected more than 350,000 individuals and killed more than 16,000 people. SARS-CoV-2 is the seventh member of the coronavirus family to affect humans. Symptoms of COVID-19 include fever (88%), cough (68%), vomiting (5%) and diarrhoea (3.7%), and transmission of SARS-CoV-2 is thought to occur from human to human via respiratory secretions released by the infected individuals when coughing and sneezing. COVID-19 can be detected through computed tomography scans and confirmed through molecular diagnostics tools such as polymerase chain reaction. Currently, there are no effective treatments against SARS-CoV-2, hence antiviral drugs have been used to reduce the development of respiratory complications by reducing viral load. The purpose of this review is to provide a comprehensive update on the pathogenesis, clinical aspects, diagnosis, challenges and treatment of SARS-CoV-2 infections.

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“…Cai et al showed that vitamin C can improve the outcome in pneumonia due to in uenza virus by its effect on inhibition of CORT synthesis which reduces the susceptibility to in uenza viral infection 20 . Regarding critically ill COVID-19 patients with pneumonia with a high mortality rate, it seems that timely administration of high dose intravenous vitamin C has been particularly effective by inhibiting the production of cytokines storm due to COVID-19 21 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit

Mahmoodpoor

Shadvar

Sanaie

et al. 2020

Preprint

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Background: Critically ill patients are frequently suffering from vitamin C deficiency. Previous studies showed that high doses of vitamin C administration had conflicting results on clinical outcomes in patients with severe sepsis, burns and trauma. Because of high incidence and morbidity/mortality with severe pneumonia, we aimed to investigate the effect of administration of high dose vitamin C in critically ill patients with severe pneumonia.Methods: Eighty critically ill patients with pneumonia were enrolled in this randomized double blinded clinical trial. Patients with CURB-65 score >3, one major criteria, or ≥3 minor criteria were considered as severe pneumonia. Patients were randomly assigned to intervention or placebo groups receiving standard treatment plus 60 mg/kg/day vitamin C as continuous infusion or normal saline in the same volume correspondingly for 96 hours. Serum levels of vitamin C were noted at baseline and 48 hours after vitamin C administration. Duration of mechanical ventilation, ICU length of stay, PaO2/FiO2 and mortality rate were noted for all patients till the 28th day. Any complications related to vitamin C administration were recorded. (IRCT registration number: IRCT20190312043030N1, Registration date: 2019-08-26, seied hadi saghaleini).Results: Duration of mechanical ventilation and vasopressor use were significantly lower in intervention group (p: <0.001 and 0.003, respectively). Baseline levels of vitamin C in both groups did not have significant difference but its levels increased in intervention group and decreased in control group during the study period. Mortality rate insignificantly decreased in intervention group (p: 0.17). Three patients showed hypotension and tachycardia during the administration of vitamin C which was self-limited with decreasing the dose of vitamin C. Conclusion: Our results showed that the intravenous administration of a relatively high dose of vitamin C to critically ill patients with severe pneumonia was safe and could decrease the inflammation, mechanical ventilation duration and vasopressor use without any significant effect on mortality.

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High-dose intravenous vitamin C treatment for COVID-19

Cited by 47 publications

References 15 publications

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options

Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit

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