High dose of maternal folic acid supplementation is associated to infant asthma

Yang, Liu; Jiang, Li‐Wen; Bi, Minghong; Jia, Xiaodong; Wang, Youqing; He, Chuan; Yao, Yao; Wang, Jun; Wang, Zhiping

doi:10.1016/j.fct.2014.11.006

Cited by 44 publications

(56 citation statements)

References 25 publications

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“…table 1). Findings from a recent large study also indicate that some of the conflicting results in the literature may be due to the dosage or duration of folic acid supplementation; total folic acid consumption as supplements throughout pregnancy were associated with either decreased or increased infant asthma rates, depending on dose, and compared to a reference group who did not consume supplements [110]. The design of that particular study did not allow the effects of the daily dose to be separated from those of the duration of supplementation.…”

Section: Pregnancy Diet and Nutritional Interventionsmentioning

confidence: 99%

“…While periconceptional folate supplementation reduces the risks of neural tube defects in babies [106] without appearing to increase the risks of allergy in offspring, there is some evidence that late or entire pregnancy folate supplementation might increase the risk of allergy in children [107,108,109,110,111], particularly at high doses (≥5 mg/day). Not all studies support any such relationship [112,113] (online suppl.…”

Section: Pregnancy Diet and Nutritional Interventionsmentioning

confidence: 99%

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In utero Programming of Allergic Susceptibility

Grieger

Clifton

Tuck

et al. 2016

Int Arch Allergy Immunol

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Background: Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures. Methods: A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood. Results: Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. In contrast, restricted growth in utero, a healthy maternal diet and a larger family size are protective, but the mechanisms here are unclear and require further investigation. Conclusion: To ameliorate the allergy pandemic in young children, we must define prenatal mechanisms that alter the programming of the fetal immune system and also identify specific targets for antenatal interventions.

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Section: Pregnancy Diet and Nutritional Interventionsmentioning

confidence: 99%

Section: Pregnancy Diet and Nutritional Interventionsmentioning

confidence: 99%

In utero Programming of Allergic Susceptibility

Grieger

Clifton

Tuck

et al. 2016

Int Arch Allergy Immunol

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“…However, a systematic review with meta-analysis of five studies on maternal supplementation (N ¼ 14 438) found no relationship between folic acid and allergic disease. A subsequent case-control study [16] (150 cases/212 controls) demonstrated a dose response relationship with asthma where high supplemental doses (>72 000 mg total over the pregnancy equivalent to 180 days) were associated with an increased risk of asthma (OR 3.16; 95% CI 1.15-8.71), whereas intermediate doses had no relationship and low doses (<36 000 total dose equivalent to 90 days) were protective. The recall bias associated with case-control studies need to be taken into account when interpreting these results.…”

Section: Key Pointsmentioning

confidence: 94%

Breastfeeding and perinatal exposure, and the risk of asthma and allergies

Lodge

Dharmage

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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A diverse range of exposures were associated with allergic disease risk, highlighting the susceptibility of children during the perinatal period. Clinicians should reinforce public health messages concerning maternal obesity, smoking, and breastfeeding. The infant gut microbiome is emerging as an important hypothesis, which may mediate the relationship between many perinatal exposures and allergic disease.

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“…In humans, some studies have shown that a high dose of folic acid supplementation for mother during pregnancy was associated with an increased risk of infant asthma [91,92], whereas supplementation with a relatively low dose was associated with a decreased risk of infant asthma [91]. Other studies have shown that maternal intake of folate during pregnancy does not influence risk of allergic disease [88,93].…”

Section: Folic Acidmentioning

confidence: 97%

Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases

Sabounchi

Bollyky

Nadeau

2015

Curr Allergy Asthma Rep

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There has been significant increase in the prevalence of atopy over the past decade that cannot be explained by genetic predisposition. Environmental factors including nutrition, the uterine environment, and lifestyle factors are known to play a role in gene expression through epigenetic modifications. In this article, we review the literature on the environmental impact on epigenetic modulation of atopic diseases including asthma, food allergy, eczema, and allergic rhinitis. Recent public release of epigenomic data for hundreds of human tissues provides a powerful resource for further investigation of the molecular basis of atopic diseases.

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High dose of maternal folic acid supplementation is associated to infant asthma

Cited by 44 publications

References 25 publications

In utero Programming of Allergic Susceptibility

In utero Programming of Allergic Susceptibility

Breastfeeding and perinatal exposure, and the risk of asthma and allergies

Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases

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