High-Dose Photodynamic Therapy Increases Tau Protein Signals in Drosophila

Willis, Jace A.; Cheburkanov, Vsevolod; Yakovlev, Vladislav V.

doi:10.1109/jstqe.2023.3270403

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…It is important to point out that tissue fixation is known to alter viscoelastic properties of biological samples 29 and neuronal tissues in particular. 30 However, comparing samples under the same environmental and imaging conditions yields insightful information about tissue’s viscoelastic properties.…”

Section: Resultsmentioning

confidence: 99%

Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy

Cheburkanov,

Du,

Brogan

et al. 2023

Neurophoton.

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Peripheral nerves are viscoelastic tissues with unique elastic characteristics. Imaging of peripheral nerve elasticity is important in medicine, particularly in the context of nerve injury and repair. Elasticity imaging techniques provide information about the mechanical properties of peripheral nerves, which can be useful in identifying areas of nerve damage or compression, as well as assessing the success of nerve repair procedures.Aim: We aim to assess the feasibility of Brillouin microspectroscopy for peripheral nerve imaging of elasticity, with the ultimate goal of developing a new diagnostic tool for peripheral nerve injury in vivo.Approach: Viscoelastic properties of the peripheral nerve were evaluated with Brillouin imaging spectroscopy.Results: An external stress exerted on the fixed nerve resulted in a Brillouin shift. Quantification of the shift enabled correlation of the Brillouin parameters with nerve elastic properties.Conclusions: Brillouin microscopy provides sufficient sensitivity to assess viscoelastic properties of peripheral nerves.

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Section: Resultsmentioning

confidence: 99%

Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy

Cheburkanov,

Du,

Brogan

et al. 2023

Neurophoton.

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Emerging paradigms in Alzheimer's therapy

Preethy H,

Rajendran,

Sukumar

et al. 2024

European Journal of Pharmacology

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Investigating chemotherapy effects on peripheral nerve elasticity

Cheburkanov,

Du,

Berezin

et al. 2024

Visualizing and Quantifying Drug Distribution in Tissue VIII

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Chemotherapy is one of the treatment methods aimed at killing cancer cells and hindering their metastasis. However, chemotherapy is known to induce multiple adverse side-effects. One of them is peripheral neuropathy, which causes significant discomfort to the cancer patient. It is hypothesized that neuropathy is directly linked to peripheral nerve damage or elasticity change. In this study we have attempted to use Brillouin spectroscopy to evaluate nerve elasticity changes and correlate them to the effects of chemotherapy.

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High-Dose Photodynamic Therapy Increases Tau Protein Signals in Drosophila

Cited by 3 publications

References 37 publications

Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy

Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy

Emerging paradigms in Alzheimer's therapy

Investigating chemotherapy effects on peripheral nerve elasticity

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