High-Dose-Rate Brachytherapy for Medically Inoperable Stage I Endometrial Cancer

Consensus statement for brachytherapy for the treatment of medically inoperable endometrial cancer

“…Late toxicities from radiotherapy include bowel injury such as obstruction and fistula formation, proctitis, sigmoid stricture, hemorrhagic cystitis, bladder contracture, pelvic fracture, chronic diarrhea, vaginal stenosis and agglutination, and secondary malignancies. In 16 studies using LDR brachytherapy, the range of late complications was 0e17.3% (30), and in 10 studies using HDR brachytherapy, the range of late complications was 0e14.7% (30). As noted previously, medically inoperable patients by definition cannot undergo surgical management of complications, and as such, prevention is the best option.…”

“…Results from the literature from 1998 forward have been added to summary tables previously reported and reproduced with permission from Nguyen and Petereit (30). a Actuarial data.…”

Definitive radiation therapy for endometrial cancer in medically inoperable elderly patients

“…Another series, from the University of Wisconsin, reported on 36 patients with stage I endometrial carcinoma treated with HDRB alone to a median dose of 46 Gy in 5 weekly applications (22). The median age was 65 with a range of 37e90.…”

Image-guided high-dose-rate brachytherapy in inoperable endometrial cancer

“…A small number of HDR brachytherapy reports in endometrial cancer are found. 33,[44][45][46][47][48][49][50][51][52] When we compare the results from these publications, the local control rate and side effect profile of 3D planning seems better than 2D planning as shown in Table 2, and this may also lead to a better overall survival rate. However, this conclusion should be regarded with caution in view of the small selected numbers of patients included.…”