High dose rate brachytherapy using molds after chemoradiotherapy for oral cavity cancer

Chatani, Masashi; Tsuboi, Kazuki; Yagi, Masayuki; Fujiwara, Kanta; Tachimoto, Rika; Yoshioka, Hideo

doi:10.1007/s11604-011-0005-z

Cited by 13 publications

(9 citation statements)

References 10 publications

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“…[40] reported that mold therapy after chemoradiotherapy is a non-invasive procedure yielding a reproducible distribution of the radiation dose that closely fits the tumor volume. This technique seems to be a safe and effective treatment method for selected early and superficial squamous cell carcinomas of the oral cavity, although the indications for this treatment method are limited.…”

Section: Introductionmentioning

confidence: 99%

High dose rate brachytherapy for oral cancer

Yamazaki

Yoshida

Yoshioka

et al. 2012

Journal of Radiation Research

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Brachytherapy results in better dose distribution compared with other treatments because of steep dose reduction in the surrounding normal tissues. Excellent local control rates and acceptable side effects have been demonstrated with brachytherapy as a sole treatment modality, a postoperative method, and a method of reirradiation. Low-dose-rate (LDR) brachytherapy has been employed worldwide for its superior outcome. With the advent of technology, high-dose-rate (HDR) brachytherapy has enabled health care providers to avoid radiation exposure. This therapy has been used for treating many types of cancer such as gynecological cancer, breast cancer, and prostate cancer. However, LDR and pulsed-dose-rate interstitial brachytherapies have been mainstays for head and neck cancer. HDR brachytherapy has not become widely used in the radiotherapy community for treating head and neck cancer because of lack of experience and biological concerns. On the other hand, because HDR brachytherapy is less time-consuming, treatment can occasionally be administered on an outpatient basis. For the convenience and safety of patients and medical staff, HDR brachytherapy should be explored. To enhance the role of this therapy in treatment of head and neck lesions, we have reviewed its outcomes with oral cancer, including Phase I/II to Phase III studies, evaluating this technique in terms of safety and efficacy. In particular, our studies have shown that superficial tumors can be treated using a non-invasive mold technique on an outpatient basis without adverse reactions. The next generation of image-guided brachytherapy using HDR has been discussed. In conclusion, although concrete evidence is yet to be produced with a sophisticated study in a reproducible manner, HDR brachytherapy remains an important option for treatment of oral cancer.

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Section: Introductionmentioning

confidence: 99%

High dose rate brachytherapy for oral cancer

Yamazaki

Yoshida

Yoshioka

et al. 2012

Journal of Radiation Research

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“…[ 2 ], and Chatani et al . [ 16 ] have presented their experience with the use of customized surface mould-based HDR brachytherapy, and concluded that it is safe and efficient for early and superficial lip and buccal mucosa lesions. Matsuzaki et al .…”

Section: Discussionmentioning

confidence: 99%

High-dose-rate brachytherapy in severe trismus: Making it happen!

Dholam

Singh

Laskar

et al. 2018

jcb

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Brachytherapy has been widely employed as a salvage or adjuvant modality in localized early and/or recurrent lesions. In recent years, advances in brachytherapy techniques have helped to achieve better loco-regional disease control and higher survival rates at the cost of limited morbidity. This is mainly owing to the development of technologically advanced three-dimensional computer planning systems and treatment delivery techniques. Low-dose-rate brachytherapy has been substituted by high-dose-rate and pulsed-dose-rate techniques, which allow better dose optimization. Inter-disciplinary approach results in fabrication of customized intra-oral surface mould, which allows accurate dose delivery, excellent dose distribution, and is less time-consuming. However, fabrication of surface mould becomes extremely challenging when intra-oral anatomic factors are unfavorable. We present a report on the management of a previously-irradiated completely edentulous patient with severe trismus for whom high-dose-rate surface mould brachytherapy had been prescribed. A unique, reliable, and practical solution has been presented based firmly on the scientific knowledge of contemporary implant dentistry.

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“…Chatani et al . [ 13 ] in a study of nine cases reported that mould therapy after chemo-radiotherapy is non-invasive and yields a reproducible distribution of the radiation dose tightly fitting tumour volume. Matsuzaki et al .…”

Section: Discussionmentioning

confidence: 99%

Dosimetric analysis and clinical outcomes in CT-based mould brachytherapy in early oral cancers in patients unfit for surgery

Mukherji

Sinnatamby²,

Kandasamy³

et al. 2015

jcb

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PurposeBrachytherapy in the oral cavity is an important alternative to conventional treatment, and provides a high localized dose and short overall treatment time. A rapid fall of dose beyond radioactive source makes it possible for increased tumour control and sparing surrounding tissue, while short overall treatment duration reduces risk of tumour repopulation. Moulds are fabricated to hold the catheters in position as closely as possible to tumour surface to provide adequate dose coverage of tumour volume and increase distance to other normal surrounding structures. Image based planning and dose optimisation help in better defining target volume and dose coverage.Material and methodsA retrospective analysis of patients of early squamous cell carcinomas of lip and buccal mucosa from September 2011 to June 2014 to study response to mould brachytherapy. Double plane moulds were prepared for all lip cancer cases and single plane for buccal mucosa cases. Patients are being followed up till disease recurrence. In this study evaluation was done of the technique used, planning details, response to therapy, and reactions encountered.ResultsNine patients treated by mould therapy were reviewed; seven cases were of lip and two of buccal mucosal cancers. Dose delivered ranged from 12.5-48 Gy in fraction sizes of 2.5-3.5 Gy. Equivalent dose in 2 Gy fractions (EQD2) ranged from 18-64 Gy. Maximum dose to organs at risk (OAR) was 91% of prescribed dose. Local mucositis was only reaction in all cases, which resolved in 3-6 weeks. Median follow-up was 19 months. Eight out of nine patients are in remission at a minimum of 7 months (1 case, rest over 14 months) post therapy and only patient had nodal recurrence at 18 months.ConclusionsMould therapy is an effective treatment method for selected early and superficial squamous cell carcinomas of the oral cavity, although indications are limited.

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High dose rate brachytherapy using molds after chemoradiotherapy for oral cavity cancer

Abstract: HDR brachytherapy using the mold technique after chemoradiotherapy is a safe and excellent method for selected early and superficial oral cavity cancers.

Cited by 13 publications

References 10 publications

High dose rate brachytherapy for oral cancer

High dose rate brachytherapy for oral cancer

High-dose-rate brachytherapy in severe trismus: Making it happen!

Dosimetric analysis and clinical outcomes in CT-based mould brachytherapy in early oral cancers in patients unfit for surgery

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