High-dose-rate interstitial brachytherapy for previously untreated cervical carcinoma

Early clinical outcomes of ultrasound-guided CT-planned high-dose-rate interstitial brachytherapy for primary locally advanced cervical cancer

“…The two IS series most similar to our data in terms of the BT schedule are the experiences by and Yoshida et al (19) and Isohashi et al (21). Both used 6 Gy per fraction for five to six fractions given in a single implant.…”

Reirradiation Using High-Dose-Rate Interstitial Brachytherapy for Locally Recurrent Cervical Cancer: A Single Institutional Experience

“…The frequency of grade 3/4 toxicities (25%) in the current study was similar to those reported by other investigators but approximately 3 times higher than the 8% observed in patients with previously untreated cervical cancer who received EBRT plus HDR-ISBT at our institution. 13 These results strongly indicate the need for extra effort to reduce the toxicities of this salvage treatment.…”

“…12 The implant and treatment planning techniques were slightly modified versions of previously reported methods. 13 Implantation was performed under epidural anesthesia and involved interstitial stainless steel needles being inserted using the Martinez Universal Perineal Interstitial Template. The template and its vaginal cylinder were inserted into the vagina under transrectal ultrasound imaging guidance and sutured to the perineal skin.…”

Dosimetric comparison of volume-based and inverse planning simulated annealing–based dose optimizations for high–dose rate brachytherapy

“…Dose optimization in brachytherapy is not a new concept and has been studied for several decades because of technological advances both in computing power and in imaging technology (computed tomography [CT] and magnetic resonance imaging). 1,2 High-dose rate (HDR) brachytherapy treatment planning often involves optimization methods to calculate the dwell times at dwell positions of the radioactive source along specified applicator paths. The goal of HDR planning is to produce an acceptable optimized plan within a reasonable time period, which meets the desired dose constraints.…”