2000
DOI: 10.1007/bf03018950
|View full text |Cite
|
Sign up to set email alerts
|

High-dose S(+)- ketamine improves neurological outcome following incomplete cerebral ischemia in rats

Abstract: 572CAN J ANESTH 2000 / 47: 6 / pp [572][573][574][575][576][577][578] Purpose: To determine the effects of the non-competitive NMDA-receptor antagonist S(+)-ketamine on neurological outcome in a rat model of incomplete cerebral ischemia. Methods: Thirty rats were anesthetized, intubated and mechanically ventilated with isoflurane, O 2 30% and nitrous oxide 70%. Following surgery animals were randomly assigned to one of the following treatment groups: Rats in group 1 (n=10, control) received fentanyl (bolus: 10… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
22
1
1

Year Published

2001
2001
2020
2020

Publication Types

Select...
4
4

Relationship

1
7

Authors

Journals

citations
Cited by 55 publications
(25 citation statements)
references
References 27 publications
1
22
1
1
Order By: Relevance
“…IC, infarct core; scale bar = 250 (m in images a1-d1, a2-d2 and a3-d3. For interpretation of the references to color in this figure legend, the reader is referred to the web version of this paper addition, our results were not in line with experiments that high-dose ketamine improved neurological outcome of cerebral ischemia rats induced by combined unilateral common carotid artery ligation and hemorrhagic hypotension to 35 mm Hg for 30 min [41]. This may be explained by the difference of the selected isomers in the present study (ketamine-racemate vs. S (1) ketamine) as well as by the use of different ischemia models.…”
Section: Discussioncontrasting
confidence: 74%
“…IC, infarct core; scale bar = 250 (m in images a1-d1, a2-d2 and a3-d3. For interpretation of the references to color in this figure legend, the reader is referred to the web version of this paper addition, our results were not in line with experiments that high-dose ketamine improved neurological outcome of cerebral ischemia rats induced by combined unilateral common carotid artery ligation and hemorrhagic hypotension to 35 mm Hg for 30 min [41]. This may be explained by the difference of the selected isomers in the present study (ketamine-racemate vs. S (1) ketamine) as well as by the use of different ischemia models.…”
Section: Discussioncontrasting
confidence: 74%
“…Ketamine, like most anesthetics, has been suggested to have a neuroprotective effect (Reeker et al 2000). The extent to which Ketamine might have protected the brain tissue from ischemia in our study is not known.…”
Section: Discussionmentioning
confidence: 86%
“…19 However, low doses of S(+)-ketamine (0.5 mg·kg -1 ·min -1 ) shifted the autoregulatory curve towards higher MAP values, an effect that is likely related to elevated sympathetic tone of cerebral vessels. 7,19 Increasing the dose of S(+)-ketamine (1.0 mg·kg -1 ·min -1 ) reversed this effect along with a decrease in plasma-catecholamine concentrations. These data suggest that changes in CBF seen in historical studies are unlikely related to impaired CBF autoregulation in humans and animals.…”
Section: Discussionmentioning
confidence: 98%
“…5 In animal models of cerebral ischemia and traumatic head injury ketamine and its enantiomere S(+)-ketamine showed brain protective potential even when administered one hour after the insult. [6][7][8] Although cerebrovascular autoregulation in the rat was intact with S(+)-ketamine, it is unclear whether total iv anesthesia (TIVA) using S(+)-ketamine in combination with propofol affects cerebrovascular autoregulation in humans. Therefore the present study investigates the effects of S(+)-ketamine and propofol (a combination adequate to provide anesthesia during surgery) on the dynamic component of cerebrovascular autoregulation in comparison to sevoflurane anesthesia.…”
Section: Discussionmentioning
confidence: 99%