High-dose Spatially-fractionated GRID Radiation Therapy (SFGRT): A Comparison of Outcomes of Treatment Delivered Through Cerrobend GRID versus MLC GRID

Neuner, Geoffrey; Walde, Noam Vander; Ha, J.K.; Yu, Chenchen; Mohiuddin, Mohammed; Regine, W.F.

doi:10.1016/j.ijrobp.2008.06.1435

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its basic principle is to create within the tumor volume multiple localized high-dose islands with a certain degree of separation to form lower dose regions. This new proposal for radiation therapy delivery is based on: 1) the proven effectiveness of boosting tumor response using 2D Spatial Fractionated GRID Radiotherapy (SFGRT), and 2) the new advances in radiation delivery which allow creating three dimensional (3D) high dose regions inside the tumor volume without the limitation of high toxicity in the peripheral normal tissue regions [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

LATTICE Radiotherapy with RapidArc for Treatment of Gynecological Tumors:Dosimetric and Early Clinical Evaluations

Amendola¹,

Pérez²,

Amendola³

et al. 2010

Cureus

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

LATTICE Radiotherapy with RapidArc for Treatment of Gynecological Tumors:Dosimetric and Early Clinical Evaluations

Amendola¹,

Pérez²,

Amendola³

et al. 2010

Cureus

View full text Add to dashboard Cite

“…Although relatively small numbers of patients have received GRID treatment either with orthovoltage or more recently with MV X-rays, significant and dramatic tumor regressions have been observed and reported [4][5][6][7], even though GRID therapy, in contrast to conventional approaches, does not attempt to treat the total tumor volume with a relatively uniform dose.…”

Section: Introductionmentioning

confidence: 99%

On Modern Technical Approaches of Three-Dimensional High-Dose Lattice Radiotherapy (Lrt)

Ahmed²,

Wright³

et al. 2010

Cureus

View full text Add to dashboard Cite

Purpose: Two-dimensional (2D) high-dose GRID radiotherapy has shown effective tumor control in the clinical setting, and radiobiological data suggest potent bystander/abscopal effects with this technique. We present a new technical concept using modern radiation therapy instrumentation to advance traditional GRID treatment to modern three-dimensional (3D) high-dose LATTICE radiotherapy (LRT). Materials and Methods: An array of focused high-dose volumes, in essence a lattice of doses in 3D, can be generated through modern techniques resulting in highly heterogeneous dose distributions within the tumor volume, leaving adjacent and peripheral normal tissue minimally exposed. Two technical approaches were investigated for this novel concept: noncoplanar focused beams and MLC-based or aperture-modulated arc. Results: High magnitude dose oscillation is essential in traditional GRID therapy. The 3D "peak-to-valley" dose fall-off (100% to 20-30%) characteristic was attainable in test LRT cases, with a greater ability to place dose peaks within the radiation target volume and minimal dose to surrounding normal tissue. Conclusion: Modern radiotherapy methods are readily available to deliver 3D high-dose LATTICE radiotherapy with superior dosimetry compared to the 2D GRID technique. This is an easily accessible therapeutic modality that could potentially result in comparable or superior treatment outcomes than traditional 2D GRID therapy when implemented in the clinical setting.

show abstract

Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials

Li,

Mayr,

Griffin

et al. 2024

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

High-dose Spatially-fractionated GRID Radiation Therapy (SFGRT): A Comparison of Outcomes of Treatment Delivered Through Cerrobend GRID versus MLC GRID

Cited by 4 publications

References 0 publications

LATTICE Radiotherapy with RapidArc for Treatment of Gynecological Tumors:Dosimetric and Early Clinical Evaluations

LATTICE Radiotherapy with RapidArc for Treatment of Gynecological Tumors:Dosimetric and Early Clinical Evaluations

On Modern Technical Approaches of Three-Dimensional High-Dose Lattice Radiotherapy (Lrt)

Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials

Contact Info

Product

Resources

About