High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution

Abstract

The prevalence of Vitamin D deficiency is increasing worldwide, which has be shown to be associated with increased risk of cardiovascular disease (CVD), autoimmune disease, and metabolic syndrome. These conditions are also associated with a heightened state of inflammation. The aim of the current study was to evaluate the effect of vitamin D supplementation on serum C-Reactive Protein (CRP) level and Neutrophil-to-lymphocyte ratio (NLR) distribution in a large cohort of adolescent girls. A total of 580 adolescent girls were recruited follow by evaluation of CRP and hematological parameters before and after supplementation with vitamin D supplements as 9 of 50000 IU cholecalciferol capsules for 9 weeks taken at weekly intervals. At baseline, serum hs-CRP level was 0.9 (95%CI: 0.5-1.8), while this value after intervention was reduced to 0.8 (95%CI: 0.3-1.6; P = 0.007). Similar results were also detected for NLR (e.g., NLR level was 1.66 ± 0.72 and 1.53 ± 0.67, P = 0.002, before and after therapy with compliance rate of >95.2%). Moreover, we found an association between hs-CRP and BMI, triglyceride, white blood cell count, and lymphocytes. Interestingly we observed a significant reduction in neutrophil count and CRP level after high dose vitamin D supplementation. Our findings showed that the high dose supplementation of vitamin D affects measures of systemic inflammation: reductions in High Sensitivity C-Reactive Protein level and Neutrophil-to-lymphocyte ratio (NLR) distribution. J. Cell. Biochem. 118: 4317-4322, 2017. © 2017 Wiley Periodicals, Inc.

Genetic and epigenetic factors influencing vitamin D status

“…Several studies have reported a strong relationship between vitamin D status and different health outcomes (Bahrami et al, ; McCullough, Bostick, & Mayo, ; Tabatabaeizadeh et al, ). Attention has now turned to the gene‐environment interactions that could have an impact on various vitamin D‐related disorders (Ahn et al, ; Dickinson et al, ).…”

Serum Vitamin D Levels in Patients with Myelodysplastic Syndromes: A Retrospective Single-Center Analysis

“…The association between immune signaling and VD is further supported by the observation that in our patient cohort VD levels decrease while the NLR increases. NLR is a recognized tool for the assessment of the systemic inflammatory response and has been shown to be affected by VD [25]. Of clinical relevance is the association between MDS and autoimmune disorders that have been reported in several case report studies and long-term follow-up studies [26,27].…”

“…The neutrophil to lymphocyte ratio (NLR) was defined as the absolute neutrophil count (ANC) divided by absolute lymphocyte count. 25 …”

Determinants of the magnitude of response to vitamin D supplementation in adolescent girls identified using a decision tree algorithm

“…VitD deficiency (25(OH)D <50 nmoL/L) is one of the most frequent nutritional problems in the world and has been associated with many unfavorable health outcomes . Oral VitD supplementation is an inexpensive, effective and easy‐to‐use for improving VitD status.…”

“…2 VitD deficiency (25(OH)D <50 nmoL/L) is one of the most frequent nutritional problems in the world and has been associated with many unfavorable health outcomes. 3 Oral VitD supplementation is an inexpensive, effective and easyto-use for improving VitD status. However, in response to an administration dose of VitD supplement, the increase in 25(OH)D level is different between individuals.…”