1997
DOI: 10.1046/j.1365-2362.1997.2170765.x
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High doses of hydroxyethyl starch and human albumin have similar effects on monocyte function and oncotic pressure

Abstract: The accumulation of hydroxyethyl starches (HES) in monocytes/macrophages has raised concern over their potential detrimental effects on host defences. We assessed prospectively the function of circulating monocytes isolated from patients treated with plasma exchange (PE) using HES. The study was carried out in the medical intensive care unit of a university hospital. Eight patients underwent PE for neurological disorders. Each patient underwent three PEs, 48 h apart. The total exchange volume was 4 L per PE. O… Show more

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Cited by 5 publications
(3 citation statements)
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“…Under physiological conditions colloidal fluids largely remain within the capillaries and attract water through an increase of the intravascular colloid osmotic pressure [23,24]. However, we were not able to detect an increase of colloid osmotic pressure after HES infusion.…”
Section: Discussioncontrasting
confidence: 58%
See 1 more Smart Citation
“…Under physiological conditions colloidal fluids largely remain within the capillaries and attract water through an increase of the intravascular colloid osmotic pressure [23,24]. However, we were not able to detect an increase of colloid osmotic pressure after HES infusion.…”
Section: Discussioncontrasting
confidence: 58%
“…Based on our findings and those of others we would suggest to use human albumin only for a few strict indications such as in some cases of nephrotic syndrome and as treatment of decompensated liver cirrhosis with ascites [24]. Resuscitation of critically ill patients can be succesfully done with crystalloids.…”
Section: Discussionmentioning
confidence: 69%
“…Recent clinical investigations suggest that the phagocytotic capacity and signal transduction of monocytes are unaltered by intracellular colloid storage after incubation with HES resuscitation fluids in vitro. [20][21][22][23] There is no liter-ature, however, regarding the effect of long-term in vivo exposure to HES and the effect on the PBMNCs. In our patient, the phagocytic capacities of the peripheral blood monocytes and granulocytes were within normal limits.…”
Section: Discussionmentioning
confidence: 99%