High doses of ionizing radiation on bone repair: is there effect outside the irradiated site?

Rocha, Flaviana Soares; Dias, Paulo Eduardo Miamoto; Limirio, Pedro Henrique Justino Oliveira; Lara, Vítor Carvalho; Batista, Jonas Dantas; Dechichi, Paula

doi:10.1016/j.injury.2016.11.033

Cited by 7 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The right legs did not receive radiation and were designated to be the control group (C30 and C60 groups). The beam was collimated and irradiation was delivered using a linear accelerator (Varian Clinac® 600C S/N 0310, Palo Alto, CA, USA) with a total dose of 30 Gy in one session [17]. The animals were euthanized 30 or 60 days after radiation.…”

Section: Methodsmentioning

confidence: 99%

Ionizing radiation and bone quality: time-dependent effects

et al. 2019

Self Cite

View full text Add to dashboard Cite

BackgroundThe aim of this study was to evaluate the ionizing radiation (IR) effects on rat bone 30 and 60 days after irradiation.MethodsWistar rats were submitted to IR (30 Gy) on the left leg and were euthanized after 30 and 60 days. The legs were divided into four groups according to the treatment and euthanization time: C30 and C60 (right leg–without IR), IR30 and IR60 (left leg-with IR).ResultsCT analysis showed more radiodensity in C60 compared with other groups, and IR60 showed more radiodensity than IR30. In histomorphometric analysis, C30 showed lower bone matrix values compared with IR30 and C60. Lacunarity analyses showed more homogeneous bone channel distribution in C30 than IR30. ATR-FTIR showed decrease in ratio of mature and immature crosslinks in IR30 compared with C30. Crystallinity Index was decrease in IR60 compared with C60. The Amide III + Collagen/HA ratio was increased in C60 compared with C30; however this ratio decreased in IR60 compared with IR30. Biomechanical analysis showed lower values in IR groups in both time.ConclusionsIR damaged bone quality and decreased stiffness. Moreover, the results suggested that the deleterious effects of IR increased in the late time points.

show abstract

Section: Methodsmentioning

confidence: 99%

Ionizing radiation and bone quality: time-dependent effects

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…20 One of the major complication-promoting factors was postoperative RT of the graft bed leading to vascular fibrosis and endothelial damage 21 and lowered bone regeneration. 11 Patients in our series, with primary OSCC and bone infiltration or lymph node involvement as established by the pathologist, received RT with a resulting total dosage of 63 to 70 Gy. In sub-group I, the time between mandibular replacement and the start of RT was 42 days on average (range 24-59 days).…”

Section: Discussionmentioning

confidence: 99%

The Osteocutaneous Fibular Flap for Mandibular Replacement—Which Factors Influence Long-Term Success?

Kolk

Haidari

Wolff

et al. 2017

J Reconstr Microsurg Open

View full text Add to dashboard Cite

Background The free fibular flap (FFF) is established for mandibular reconstruction. Some complications, such as non-union, fistulas, and complete graft loss, are sometimes unavoidable. There are no clinically relevant data regarding the optimum selection of osteosynthesis and risk analysis prior to reconstruction. Methods Eighty-three FFFs with up to four osteotomies were analyzed for possible complications during the course of a longitudinal analysis. Forty-one patients underwent simultaneous mandibular reconstruction after tumor resection, and another 42 subjects received FFFs due to infected osteoradionecrosis (ORN). Patients who experienced transplant losses due to vascular occlusion in the grafts were excluded from the study. Results The most common complications were fistulas, bony non-union, and failure of osteosynthesis material. Major contributing risk factors were radiotherapy (p = 0.004), number of osteosynthesis plates >6 (p = 0.002), length of the harvested fibula (p = 0.027), the size of the skin island (p = 0.002), and the number of osteotomies (p = 0.001). Conclusion For the success of FFF, there are many influencing factors. If the mentioned risk factors are considered, the number of osteotomies, size of the skin paddle, and fibula are as small as possible, and a suitable osteosynthesis material is chosen, the FFF is a safe solution for mandibular reconstruction.

show abstract

“…The evaluation of the bone repair process in conditions that affects bone turnover and metabolism, may be compromised by external causes and systemic conditions, can be investigated by using µCT. Experimental studies in rats revealed alterations in bone healing, for example due to radiotherapy, which affects the bone repair (12). For evaluation of dental implants osseointegration process, the µCT associated with animal model also is commonly used, and allows the assessment of the new bone formation process around the implant.…”

Section: Animal Studies: Bone Repair Modeling and Remodelingmentioning

confidence: 99%

“…Mechanical and biological behavior of bone tissue play important role in clinical practice, especially for evaluating distinct systemic and local conditions (diseases, therapies or lesions). This property can also contribute to better understanding of bone regenerative procedures, such as: alveolar ridge and maxillary sinus augmentation procedures, bone repair and fracture healing (12), surgical reconstruction and rehabilitation, and implant osseointegration (13). µCT has shown to be the most indicated technique for assessment of the bone mass and morphology in animal models (3).…”

Section: Introductionmentioning

confidence: 99%

Use of Micro-Computed Tomography for Bone Evaluation in Dentistry

et al. 2018

Self Cite

View full text Add to dashboard Cite

Micro computed tomography (µCT) follows the same principle of computed-tomography used for patients, however providing higher-resolution. Using a non-destructive approach, samples can be scanned, and each section obtained is used to build a volume using tridimensional reconstruction. For bone analysis, it is possible to obtain information about the tissue's microarchitecture and composition. According to the characteristics of the bone sample (e.g. human or animal origin, long or irregular shape, epiphysis or diaphysis region) the pre-scanning parameters must be defined. The resolution (i.e. voxel size) should be chosen taking into account the features that will be evaluated, and the necessity to identify inner structures (e.g. bone channels and osteocyte lacunae). The region of interest should be delimited, and the threshold that defines the bone tissue set in order to proceed with binarization to separate the voxels representing bone from the other structures (channels, resorption areas, and medullary space). Cancellous bone is evaluated by means of the trabeculae characteristics and their connectivity. The cortex is evaluated in relation to the thickness and porosity. Bone mineral density can also be measured, by the amount of hydroxyapatite. Other parameters such as structure-model-index, anisotropy, and fractal dimension can be assessed. In conclusion, intrinsic and extrinsic determinants of bone quality can be assessed by µCT. In dentistry, this method can be used for evaluating bone loss, alterations in bone metabolism, or the effects of using drugs that impair bone remodeling, and also to assess the success rate of bone repair or surgical procedures.

show abstract

High doses of ionizing radiation on bone repair: is there effect outside the irradiated site?

Cited by 7 publications

References 14 publications

Ionizing radiation and bone quality: time-dependent effects

Ionizing radiation and bone quality: time-dependent effects

The Osteocutaneous Fibular Flap for Mandibular Replacement—Which Factors Influence Long-Term Success?

Use of Micro-Computed Tomography for Bone Evaluation in Dentistry

Contact Info

Product

Resources

About