High doses of testosterone increase anticonflict behaviour in rat

Bing, Ola; Heilig, Markus; Kakoulidis, Pirros; Sundblad, Charlotta; Wiklund, Lisa; Eriksson, Elias

doi:10.1016/s0924-977x(97)00095-3

Cited by 64 publications

(41 citation statements)

References 14 publications

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“…Further evidence for this concept comes from both clinical and experimental data (Eriksson and Humble 1990;Griebel 1995) which demonstrate anti-conflict effects of reduced serotonergic neurotransmission. The notion that conflict procedures may be sensitive both to anti-anxiety drugs and manipulations leading to impaired impulse control is supported by recent findings that high doses of testosterone lead to a release of punished drinking (Bing et al 1998). Thus, behavioral response inhibition mediated by the amygdala may involve serotonergic transmission, and constitute a basic module of behavioral regulation, utilized in an overlapping but differential manner by different behavioral programs.…”

Section: Discussionmentioning

confidence: 94%

Local 5,7-Dihydroxytryptamine Lesions of Rat Amygdala Release of Punished Drinking, Unaffected Plus-Maze Behavior and Ethanol Consumption

Sommer

2001

Neuropsychopharmacology

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Accumulating data indicate that serotonin uptake inhibitors are clinically effective for most if not all anxiety disorders (Perse et al. 1987;Den Boer and Westenberg 1988;Katzelnick et al. 1995;Rocca et al. 1997;Ballenger et al. 1998). While this provides renewed evidence for an involvement of 5-HT transmission in mechanisms of fear and anxiety, the role of serotonergic transmission in this context is not well understood. Experimental findings in animal studies aimed at elucidating serotonergic mechanisms in fear and anxiety have been inconsistent, possibly due to the diversity of central 5-HT systems.Thus, a 'classical hypothesis' states that increased 5-HT transmission is anxiogenic and reduction is anxiolytic. This is supported by data from animal models based on fear-induced response inhibition, such as conflict tests, for example. However, in animal models which rely on suppression of exploratory behavior by an innate fear stimulus, such as the elevated plus-maze,

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Section: Discussionmentioning

confidence: 94%

Local 5,7-Dihydroxytryptamine Lesions of Rat Amygdala Release of Punished Drinking, Unaffected Plus-Maze Behavior and Ethanol Consumption

Sommer

2001

Neuropsychopharmacology

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“…Female rats injected with T, DHT (the nonaromatizable metabolite of T), or 3␣-diol (the reduced neuroactive metabolite of DHT) showed increased entries into the open field and increased openarm time in the elevated plus maze (Frye and Lacey, 2001). Male rats exposed to high levels of T showed an increase in punished responding in the Vogel conflict test (Bing et al, 1998). Interestingly, T has been shown to ameliorate mood in hypogonadal and aged men and in perimenopausal and elderly women.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Hormonal Modulation of Anxiety Measured with Light-Enhanced Startle: Possible Role for Arginine Vasopressin in the Male

Toufexis¹,

Davis²,

Hammond³

et al. 2005

J. Neurosci.

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Increased acoustic startle in the presence of bright ambient light, a phenomenon called light-enhanced startle (LES), is dependent on the bed nucleus of the stria terminalis. In contrast to gonadally intact male rats, LES was seen reliably in castrated male rats and in female rats, although it fluctuated significantly with reproductive state. Replacement with testosterone (T) or combined estradiol (E2) and dihydrotestosterone (DHT), but not with either E2 or DHT alone, attenuated LES in castrated rats. However, replacement with T or E2 in ovariectomized rats did not decrease LES. In contrast, no sex difference was seen in the central amygdala-dependent acquisition or expression of fear-potentiated startle. In addition, T did not reduce expression of fear-potentiated startle in castrated rats. T-replaced castrated males injected centrally with mixed arginine vasopressin (AVP) V1a/b receptor antagonists daily throughout the replacement period failed to show a reduction in the expression of LES. These data suggest that T attenuates LES, but not fear-potentiated startle, through a mechanism that may involve AVP.

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“…In general, increases in either T or E2 in both male and female rodents are correlated with a decrease in anxiety-related behaviors (Frye and Walf, 2004;Bing et al, 1998; Frye et al 2007). Recent reports have shed some light on the hormone receptors that are activated to provide anxiolysis.…”

Section: Anxiety-related Behaviormentioning

confidence: 99%

The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation

Zuloaga

Puts

Jordan

et al. 2008

Hormones and Behavior

213

156

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Many studies demonstrate that exposure to testicular steroids such as testosterone early in life masculinizes the developing brain, leading to permanent changes in behavior. Traditionally, masculinization of the rodent brain is believed to depend on estrogen receptors (ERs) and not androgen receptors (ARs). According to the aromatization hypothesis, circulating testosterone from the testes is converted locally in the brain by aromatase to estrogens, which then activate ERs to masculinize the brain. However, an emerging body of evidence indicates that the aromatization hypothesis cannot fully account for sex differences in brain morphology and behavior, and that androgens acting on ARs also play a role. The testicular feminization mutation (Tfm) in rodents, which produces a nonfunctional AR protein, provides an excellent model to probe the role of ARs in the development of brain and behavior. Tfm rodent models indicate that ARs are normally involved in the masculinization of many sexually dimorphic brain regions and a variety of behaviors, including sexual behaviors, stress response and cognitive processing. We review the role of ARs in the development of the brain and behavior, with an emphasis on what has been learned from Tfm rodents as well as from related mutations in humans causing complete androgen insensitivity. Keywordscomplete androgen insensitivity syndrome -CAIS; vasopressin; anxiety; spatial memory; bed nucleus; medial amygdala; SDN-POA; sexual behavior; aggression; VMH Exposure to testicular steroids such as testosterone (T) early in life masculinizes the developing brain, leading to permanent changes in behavior in a wide variety of animal models (Morris et al., 2004). According to the aromatization hypothesis, T is converted by aromatase into 17-β estradiol (E2), which then acts on estrogen receptors (ERs) to masculinize the brain (Naftolin et al., 1975). Traditionally, aromatization is believed to be the mechanism by which the rodent brain becomes masculinized and defeminized. Some sexually dimorphic regions within the hypothalamus adhere well to this hypothesis, including the sexually dimorphic nucleus of the preoptic area (SDN-POA) and anteroventral periventricular nucleus (AVPV). T spares neuronsCorresponding author: Damian Zuloaga, Neuroscience Program, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824, Phone: Fax: (517) 432-2744, Email: E-mail: zuloagad@msu.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript from death in the SDN-POA...

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High doses of testosterone increase anticonflict behaviour in rat

Cited by 64 publications

References 14 publications

Local 5,7-Dihydroxytryptamine Lesions of Rat Amygdala Release of Punished Drinking, Unaffected Plus-Maze Behavior and Ethanol Consumption

Local 5,7-Dihydroxytryptamine Lesions of Rat Amygdala Release of Punished Drinking, Unaffected Plus-Maze Behavior and Ethanol Consumption

Sex Differences in Hormonal Modulation of Anxiety Measured with Light-Enhanced Startle: Possible Role for Arginine Vasopressin in the Male

The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation

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