High Efficacy of Concomitant Treatment of Undifferentiated (Anaplastic) Thyroid Cancer with Radiation and Docetaxel

Abstract

The preliminary data suggest that the combination of radiation and concomitant docetaxel is highly effective in patients with ATC. However, a formal phase II study is needed to assess the therapeutic potential of this combination.

Prognostic Factors and Treatment Outcomes for Anaplastic Thyroid Carcinoma: ATC Research Consortium of Japan Cohort Study of 677 Patients

“…No significant difference in CSS was seen between the three groups. Docetaxel has been introduced more recently as an effective drug for treating ATC [22,23].…”

Imatinib Enhances Docetaxel-Induced Apoptosis Through Inhibition of Nuclear Factor-κB Activation in Anaplastic Thyroid Carcinoma Cells

“…Docetaxel also arrests cells in G2/M phase, leading to increase of sensitivity of cancer cells to radio-and chemotherapies (2)(3)(4). Although the effect of the drug alone was only modest against ATC in a clinical trial (5), combined therapy with radiation and/or another type of drug may be effective (6)(7)(8).…”

18F-fluorodeoxyglucose positron emission tomography to assess response after radiation therapy in anaplastic thyroid cancer

“…The 1-/3-year actuarial OS (median: 7 months; Fig. 1), DSS (median: 8 months), and PFS (median: 5 months) in the multimodal treatment group were 27% (95% CI: 16-37)/8% (95% CI: 4-15), 31% (95% CI: 19-43)/11% (95% CI: [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], and 18% (95% CI: 8-27)/7% (95% CI: 0-14), respectively. In the MVA, RT, surgery, and pre-RT chemotherapy predicted for OS, with HRs (95% CI) respectively of 0.1 (0.03-0.6), 0.3 (0.2-0.8), and 0.5 (0.1-0.9) ( Table 3).…”