2011
DOI: 10.1186/1758-2652-14-14
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High efficacy of lopinavir/r‐based second‐line antiretroviral treatment after 24 months of follow up at ESTHER/Calmette Hospital in Phnom Penh, Cambodia

Abstract: BackgroundThe number of patients on second-line highly active antiretroviral therapy (HAART) regimens is increasing in resource-limited settings. We describe the outcomes after 24 months for patients on LPV/r-based second-line regimens followed up by the ESTHER programme in Phnom Penh, Cambodia.MethodsSeventy patients who initiated second-line HAART regimens more than 24 months earlier were included, and immuno-virological data analyzed. HIV RNA viral load was determined by real-time RT-PCR. HIV-1 drug resista… Show more

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Cited by 42 publications
(49 citation statements)
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“…[19] [n=328] Ferradini L et al, 2011 [20] [n = 70] 26 which was comparable to 67% in Rotger M et al study 27 and 44% in Castle study. 28 High-level adherence to antiretroviral therapy is associated with favorable patient outcomes.…”
Section: Conflicts Of Interestsupporting
confidence: 62%
“…[19] [n=328] Ferradini L et al, 2011 [20] [n = 70] 26 which was comparable to 67% in Rotger M et al study 27 and 44% in Castle study. 28 High-level adherence to antiretroviral therapy is associated with favorable patient outcomes.…”
Section: Conflicts Of Interestsupporting
confidence: 62%
“…Ferradini et al (2011) found 85.7% of 70 HIV-infected study participants at a center in Phnom Penh had undetectable viral load after 24 weeks of second-line ART containing LPV/r. 6 Recent evidence from southern Africa also suggests that regimens without tenofovir may impair the durability of second-line ART. 28 Baseline CD4 cell count was not associated with failure in our final model, however, another important measure of HIV disease status, baseline viral load, was.…”
Section: Discussionmentioning
confidence: 99%
“…In a study of second-line regimens containing LPV/r at a center in Cambodia, 85.7% of the 70 HIV-infected study participants had an undetectable viral load at 24 weeks. 6 However, significant challenges remain. A 2010 Cochrane review concluded that while outcomes of second-line regimens with boosted PIs are generally favorable, there is limited evidence to evaluate second-line ART in patients who fail first-line WHO-recommended treatment.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…After 12 weeks of treatment, G1 and G2 presented an equal mean increase of 141 cells and 144 cells. FERRADINI et al 8 in Cambodia, Asia, showed that a strong immune reconstitution was observed after 24 months (gain of 258 cells/mm 3 [IQR: 136-425]) of follow-up on second-line cART regimens. In 2010 in Brazil, a study by SANTOS et al 33 that compared these cell counts before and after 36 months of treatment regardless of the ARV scheme used, demonstrated an average increase of 225 T CD4+ cells.…”
Section: Discussionmentioning
confidence: 99%