High-Efficiency Air-Clad Type Silicon-Nitride Ring-Resonator for Bio-Sensing Applications

Atthi, ์์Nithi; Mendez-Astudillo, Manuel; Udomsom, Suruk; Matsumoto, Atsushi; Yamwong, Wittawat; Klunngien, Nipapan; Mankong, Ukrit; Pinlaor, Somchai; Imai, K.; Angkaew, Tuptim; Kanno, Atsushi; Yamamoto, Naokatsu; Kawanishi, Tetsuya; Umezawa, Toshimasa

doi:10.1109/ieecon53204.2022.9741668

Cited by 1 publication

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“…The purpose of this study was to increase the sensitivity of SiN photonics biosensor by applying silica NPs in enhancing the density of functionalized antibodies. The coating of Anti-S100A6 and the detection of S100A6, a proposed cholangiocarcinoma marker, have been demonstrated using the SiN resonator sensor with 400nm thick waveguide, fabricated by low-cost 500 nm technology [5].…”

Section: Introductionmentioning

confidence: 99%

Silica nanoparticles coating in silicon nitride photonic label-free biosensing of S100 calcium-binding protein A6

Udomsom

Baipaywad

Paengnakorn

et al. 2023

Colloidal Nanoparticles for Biomedical Applications XVIII

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Efficient functionalization of the silicon nitride waveguide with bioreceptors, e.g. antibodies, is key to increase antigen binding activity in photonic sensors based on silicon nitride (SiN) waveguides. A bioreceptor coating technique using silica nanoparticles (NPs) to enhance the density of functionalized antibodies, by increasing the surface areas for biomolecule binding, is proposed. The detection of S100 Calcium-Binding Protein A6 (S100A6), a proposed cholangiocarcinoma marker, has been demonstrated using the SiN resonator sensor with 400nm thick waveguide, fabricated by low-cost 500 nm technology. The NPs were synthesized by silica condensation. Antibodies were attached to the NPs by 1-ethyl-3-(3dimethyl aminopropyl)-carbodiimide (EDC)/ N-hydroxysuccinimide (NHS)-crosslinking. Then the NPs were coated on SiN sensor by N-terminal to N-terminal crosslinkers. It was found that the application of silica NPs coating showed increased sensor sensitivity at approximately 8.8 pm/(ng/ml) in optical resonant wavelength shift compared to 0.36 pm/(ng/ml) by our previous antibody coating technique using (3-Aminopropyl) triethoxysilane (APTES) silanization with EDC/NHS protein crosslink.

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Section: Introductionmentioning

confidence: 99%