High-efficiency artificial enzyme cascade bio-platform based on MOF-derived bimetal nanocomposite for biosensing

Liu, Min; Mou, Junsong; Xu, Xiaohan; Zhang, Feifei; Xia, Jianfei; Wang, Zonghua

doi:10.1016/j.talanta.2020.121374

Cited by 59 publications

(19 citation statements)

References 56 publications

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“…UOx-POD UOx-AuNP AuNP UOx-, POD- [80] LOx-POD AuNPs@MIL-101@LOx AuNPs@MIL-101 LOx-, POD- [7] Xanthine oxidase-POD Xanthine oxidase using a MOF-derived bimetal nanocomposite with POD-mimicking activity as a scaffold for GOx immobilization, Liu et al have developed a highly efficient cascade catalytic bio-platform for biosensing. [53] It is worth noting that the group of Qu embedded GOx and POD-mimicking nanozymes (i.e., graphene quantum dots(GQDs)) into an acid-dissociable zeolitic imidazolate framework-8 (ZIF-8) to prepare a biomimetic cascade catalytic nanoreactor for catalytic therapy (Figure 1C). [52] Compared with 3D bulk MOF, 2D MOFs with nanometer thickness can enhance both substrate and product diffusion.…”

Section: Mgcn-chitin-acoh Hybrid Mgcn-chitin-acoh Hybridmentioning

confidence: 99%

“…have developed a highly efficient cascade catalytic bio‐platform for biosensing. [ 53 ] It is worth noting that the group of Qu embedded GOx and POD‐mimicking nanozymes (i.e., graphene quantum dots(GQDs)) into an acid‐dissociable zeolitic imidazolate framework‐8 (ZIF‐8) to prepare a biomimetic cascade catalytic nanoreactor for catalytic therapy (Figure 1C). [ 52 ] Compared with 3D bulk MOF, 2D MOFs with nanometer thickness can enhance both substrate and product diffusion.…”

Section: Biomimetic Cascade Nanoreactorsmentioning

confidence: 99%

“…[ 17a,21a,91,123 ] Due to the excellent cascade catalytic performance of the substrate transformation and remarkable signal amplification, nanozyme‐engineered biomimetic cascade nanoreactors exhibit great potential for colorimetric biosensing applications. [ 4a,23b,40,43,44,53,60,68,107–109,124 ] For example glucose levels are an indicator reflecting human health, and therefore the monitoring of glucose levels is extremely important for medical diagnosis. To date, a great number of nanozyme‐engineered biomimetic cascade nanoreactors have been used for colorimetric glucose sensing.…”

Section: Biosensing Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Zhang

Chen

et al. 2021

Adv Funct Materials

108

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Multiple enzyme-driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits of these biological catalytic cascade systems, enormous efforts have been devoted to developing novel cascade catalytic systems to mimic biological cascade catalytic reactions over the past few years. Nanozymes, a class of enzyme mimics, are nanomaterials with enzyme-like catalytic activity. The emergence and development of nanozymes has significantly advanced the development of biomimetic cascade nanoreactors. Currently, biomimetic cascade nanoreactors driven by advanced nanozymes have been widely used and exhibit many advantages such as superior cascade catalytic efficiency and high stability, resulting in significant advancements in biosensing and biomedical applications. The latest advances in understanding the cascade catalytic mechanism of nanozyme-engineered biomimetic cascade catalytic nanoreactors and their progressive applications for biosensing and biomedical applications are comprehensively covered here. First, nanozyme and enzyme/nanozyme-engineered biomimetic cascade catalytic nanoreactors are categorized according to their catalytic mechanism and properties. Then, the biosensing and biomedical applications, including cancer therapy, antibacterial activity, antioxidation, and hyperuricemia therapy of the cascade catalytic systems are covered. The conclusion describes the most important challenges and opportunities remaining in this exciting area of research.

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Section: Mgcn-chitin-acoh Hybrid Mgcn-chitin-acoh Hybridmentioning

confidence: 99%

Section: Biomimetic Cascade Nanoreactorsmentioning

confidence: 99%

Section: Biosensing Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Zhang

Chen

et al. 2021

Adv Funct Materials

108

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“…To date, numerous efforts have been made toward developing artificial MOF‐based membranes for biochemical sensing, which could lead to the development of next‐generation bioanalytical and diagnostic tools. [ 99 ] For instance, Li and co‐workers designed highly conductive and selective fluoride ion channels that were constructed by in situ growth of Zr‐based UiO‐66‐derivative MOFs into asymmetric single‐nanochannel PET membranes ( Figure a). [ 100 ] The fabricated MOF‐based nanochannels contain specific F − binding sites along the channels, which exhibit ultrahigh F − selectivity and conductivity.…”

Section: Applicationsmentioning

confidence: 99%

Construction of Metal‐Organic Frameworks (MOFs)–Based Membranes and Their Ion Transport Applications

Yang

Wang

et al. 2021

Small Science

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Biological ion channels with delicate ion transport functions exist widely in living organisms. Bioinspired solid‐state channels have emerged as promising platforms to mimic the working mechanism of natural channels. These channels help in understanding the mechanism of ion transport in biosystems and pave the way for applications in several interesting areas. Metal‐organic frameworks (MOFs), constructed by connecting metal ions and organic ligands, exhibit high porosity and unique pore structures. They also possess tunable pore sizes and are versatile in their compositions. And there are rich molecule/ion‐specific functional groups in the frameworks, which can intelligently modulate ion transport. Thus, MOFs are promising candidates that mimic biological ion channels. Herein, the recent progress in the design and construction of artificial solid‐state MOF‐based channels is focused on. The excellent ion transport properties of MOF‐based membranes are also summarized, including ionic selectivity, ionic rectification, and ionic gating. Following this, four emerging ion transport applications, namely, energy conversion, ion/molecule separation, biosensing, and water desalination, are highlighted. Finally, an outlook on future developments and challenges in this exciting research area is presented.

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“…Metal–organic frameworks (MOFs) is a kind of crystalline material with regular network topology formed by self-assembly of nitrogen or oxygen-containing organic ligands and metal centers [ 29 – 31 ]. Among various MOF materials, MIL-100 (Fe) has the characteristics of large specific surface area, uniform pore size distribution and adjustable pore structure, and has been widely used in gas storage, catalysis, separation, drug transportation and photoelectric sensing [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

A UCMPs@MIL-100 based thermo-sensitive molecularly imprinted fluorescence sensor for effective detection of β-lactoglobulin allergen in milk products

et al. 2022

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In this study, a thermo-sensitive molecularly imprinted fluorescence sensor was developed for the specific detection of β-Lactoglobulin (β-LG) allergen in milk products. The metal–organic frameworks (MIL-100) with a high specific surface area was coated on the surface of upconversion micro-particles (UCMPs). As the core, an imprinted polymer layer allowing for swelling and shrinking with response to temperature was prepared, which exhibited high adsorption and mass transfer capabilities for β-LG allergen. The fluorescence intensity of UCMPs@MIL-100@MIP decreased linearly with the concentration of β-LG in the range of 0.1–0.8 mg mL−1, and the limit of detection was 0.043 mg mL−1. The imprinting factor reached 3.415, which indicated that excellent specificity of the UCMPs@MIL-100@MIP for β-LG allergen. In the analysis of β-LG allergen in actual milk samples, the proposed UCMPs@MIL-100@MIP fluorescence sensor produced reliable and accurate results (recovery: 86.0–98.4%, RSD: 2.8–6.8%), closely related to the results of standard HPLC method (correlation coefficient: 0.9949), indicating that its feasibility in the detection of β-LG allergen. Graphical Abstract

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High-efficiency artificial enzyme cascade bio-platform based on MOF-derived bimetal nanocomposite for biosensing

Cited by 59 publications

References 56 publications

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Construction of Metal‐Organic Frameworks (MOFs)–Based Membranes and Their Ion Transport Applications

A UCMPs@MIL-100 based thermo-sensitive molecularly imprinted fluorescence sensor for effective detection of β-lactoglobulin allergen in milk products

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