2024
DOI: 10.1002/biot.202400387
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High‐efficiency bioconversion of phytosterol to bisnoralcohol by metabolically engineered Mycobacterium neoaurum in a micro‐emulsion system

Xinxin Wang,
Xia Ke,
Hongduo Dong
et al.

Abstract: Abstract21‐Hydroxy‐20‐methylpregn‐4‐en‐3‐one (4‐HBC, bisnoralcohol) is a crucial intermediate for the synthesis of steroidal drugs. Significant challenges including by‐products formation and poor substrate solubility were still confronted in its main synthetic route by microbial conversion from phytosterol. Construction of a direct bioconversion pathway to 4‐HBC and an efficient substrate emulsion system is therefore urgently required. In this study, three novel isoenzymes of 3‐ketosteroid‐Δ1‐dehydrogenase (Ks… Show more

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